Experience with DPP-4 inhibitors in the management of patients with type 2 diabetes fasting during Ramadan

Schweizer, Anja; Halimi, Serge; Dejager, S.

doi:10.2147/vhrm.s54585

Cited by 16 publications

(20 citation statements)

References 36 publications

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“…Kobeissy et al [6] and Schweizer et al [7] reviewed clinical recommendations for subjects suffering from type 1 diabetes mellitus and advised against fasting for those at risk of infections. This suggestion is valid also for type 2 diabetes, the infectious complications of which were studied by Elmehdawi et al [8].…”

Section: Diabetes Mellitusmentioning

confidence: 99%

See 1 more Smart Citation

Ramadan fasting and infectious diseases: a systematic review

Bragazzi

Briki

Khabbache

et al. 2015

J Infect Dev Ctries

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Ramadan represents the fourth of the five pillars of the Islamic creed. Although patients are exempted from observing this duty, they may be eager to share this moment of the year with their peers. However, there are no guidelines that can help physicians to address the concerns of patients with infectious diseases fasting during Ramadan. For this purpose, we performed a systematic review. of 51 articles. Our main findings are that: 1) patients suffering from diabetes at risk of developing infectious complications should not fast; 2) Ramadan fasting has little impact on diarrheal patients; 3) HIV represents a challenge, and ad hoc drug combinations should be recommended to patients, and the patients should be advised not to take fatty meals that could interfere with the treatment; 4) Ramadan has no effect on the effectiveness of anti-helminthic therapy; and 5) patients with active ulcers should not fast, as they have a higher probability of developing complications.

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Section: Diabetes Mellitusmentioning

confidence: 99%

“…Al Sifri et al [10] investigated the safety of sitagliptin compared with sulphanylureas, in a multicenter, randomized, open-label, pragmatic trial that was reviewed by Schweizer [7]. They recruited 1,066 patients with diabetes mellitus, previously treated with sulphonylureas with or without metformin supplementation.…”

Section: Investigated Topic Referencesmentioning

confidence: 99%

Ramadan fasting and infectious diseases: a systematic review

Bragazzi

Briki

Khabbache

et al. 2015

J Infect Dev Ctries

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“…Many studies have been conducted on the effects of fasting, the majority of which are related to patients who have diabetes and management of their disease (3)(4)(5)(6)(7)(8)(9)(10). However, other studies have been conducted on non-diabetes patients and healthy subjects (11)(12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Effect of Ramadan fasting on glucose level, lipid profile, HbA1c and uric acid among medical students in Karachi, Pakistan

Khan

Rasheed

Ahmed

et al. 2017

East Mediterr Health J

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To assess the effect of Ramadan fasting on blood pressure, fasting glucose, lipid profile, uric acid, HbA1c, body mass index, body adiposity index and visceral adiposity index among fasting medical students, 35 students were recorded before, during and after Ramadan (August) 2011, for their blood pressure, anthropometric measurements, questionnaire response and blood sample. A blood sample was taken at each visit for glucose, lipid profile and HbA1c. Total physical activity, weight-to-height ratio, body adiposity index and visceral adiposity index were calculated for insulin sensitivity. Changes in anthropometric measurements were not statistically significant. However, physical activities increased significantly after Ramadan. Changes in blood pressure, fasting blood sugar, total cholesterol, HbA1c, uric acid and triglyceride were not statistically significant. Mean high density lipoprotein decreased significantly in Ramadan, while low density lipoprotein increased significantly.

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“…A recent review published in Switzerland and France has studied worldwide the role of DPP-4 inhibitors (including vildagliptin) during Ramadan fasting, and has come to the conclusion that the anti-diabetic agents DPP-4 inhibitors could be a more safer option while managing type-2 diabetes during Ramadan fasting, with a very low risk of hypoglycemia. 47 …”

Section: Vildagliptin and Ramadan Fastingmentioning

confidence: 99%

Fasting during Ramadan: efficacy, safety, and patient acceptability of vildagliptin in diabetic patients

Aziz¹

2015

DMSO

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Diabetes management during Ramadan fasting is challenging to the physician in terms of minimizing the risk of hypoglycemia. As compared to oral hypoglycemic agents (OHAs) and sulfonylureas (SUs), which carry a higher and significant risk of hypoglycemia, newer antidiabetic agents such as dipeptidyl peptidase-4 (DPP-4) inhibitors have demonstrated lower risk of hypoglycemia during Ramadan fasting, with better patient compliance. In addition to diabetes education and pre-Ramadan assessments, the physician should also consider use of DPP-4 inhibitors (such as vildagliptin) during Ramadan fasting to minimize the risk of hypoglycemia in type 2 diabetic subjects. Severe episodes of hypoglycemia have been demonstrated in recent research and clinical trials with OHAs/SUs. Conversely, these research observations have also demonstrated comparative safety and efficacy with lower risk of hypoglycemia associated with vildagliptin. Current research review has collected evidence-based clinical trials and observations for the drug vildagliptin to minimize the risk of hypoglycemia during Ramadan fasting, while at the same time focusing the role of diabetes self-management education (DSME), pre-Ramadan assessments, and patient care.

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Experience with DPP-4 inhibitors in the management of patients with type 2 diabetes fasting during Ramadan

Cited by 16 publications

References 36 publications

Ramadan fasting and infectious diseases: a systematic review

Ramadan fasting and infectious diseases: a systematic review

Effect of Ramadan fasting on glucose level, lipid profile, HbA1c and uric acid among medical students in Karachi, Pakistan

Fasting during Ramadan: efficacy, safety, and patient acceptability of vildagliptin in diabetic patients

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