Experience with Cerebellopontine Angle Epidermoids

Mohanty, Aaron; Venkatrama, Sastry Kolluri; Rao, Basrur Ravimohan; Chandramouli, Bangalore A.; Jayakumar, P. N.; Das, B. S.

doi:10.1097/00006123-199701000-00004

Cited by 53 publications

(72 citation statements)

References 26 publications

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“…The CPA is the most common location for intracranial epidermoid tumors, as 40% of all these tumors are found at this site. 2,5,15,16,24,28,29,31,33,35) In our series, 20 of 28 tumors were located in the posterior fossa, and 17 in the CPA.…”

Section: Discussionmentioning

confidence: 53%

“…9,31) Complete removal can diminish the risk of postoperative aseptic meningitis, and will prevent recurrence of the symptoms. 12,14,16,24,29) In our series, we achieved radical resection (gross total ＋ radical subtotal) in 21 of 28 cases, and subtotal resection in seven. Thirteen patients in our series developed various forms of cranial nerve paresis in the postoperative period.…”

Section: Discussionmentioning

confidence: 77%

“…2,5,8,24,25,31,33) Epidermoid tumors are the most common of all embryonal intracranial neoplasms, and account for 0.2-1.8% of all intracranial tumors and 7% of cerebellopontine angle (CPA) tumors. 2,5,15,16,24,28,29,31,33,35) Epidermoid tumors tend to spread along normal cleavage planes, and slowly fill any available subarachnoid space, including the sulci, cisterns, fissures, and ventricles. 3,8,15,24) The expanding tumor conforms to the shape of the cavities and does not disturb normal neuronal and vascular structures.…”

Section: Introductionmentioning

confidence: 99%

“…2,5,15,16,24,28,29,31,33,35) Epidermoid tumors tend to spread along normal cleavage planes, and slowly fill any available subarachnoid space, including the sulci, cisterns, fissures, and ventricles. 3,8,15,24) The expanding tumor conforms to the shape of the cavities and does not disturb normal neuronal and vascular structures. Instead, epidermoid tumors usually adhere to and surround these vital structures during growth.…”

Section: Introductionmentioning

confidence: 99%

“…13,16,29) Epidermoid tumors can cause irritation of the cranial nerves resulting in trigeminal or glossopharyngeal neuralgia, or hemifacial spasm. 8,15,20,24,29,32) Permanent cranial nerve paralysis usually only occurs after the tumor had adhered to the nerve and caused ischemia. Epidermoid tumors are histologically benign but carry a significant risk of perioperative complications, including permanent cranial nerve deficits, hydrocephalus, and aseptic meningitis due to breakdown products (keratin and cholesterol) produced during the desquamation of epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

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Surgical Treatment of Intracranial Epidermoid Tumors

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et al. 2003

Neurol. Med. Chir.(Tokyo)

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Intracranial epidermoid tumors are rare, potentially curable, benign lesions that are sometimes associated with perioperative complications, and tend to recur if not completely removed. Histologically benign epidermoid tumors may also develop into highly malignant tumors. This study evaluated on 28 cases of intracranial epidermoid tumor treated over a 13-year period by radical resection with microneurosurgical techniques. The majority of patients underwent computed tomography and/or magnetic resonance imaging within the first 24 hours postoperatively to confirm the results of surgery. Radical surgical resection was achieved in 21 of the 28 cases, and there was no operative mortality. The most common postoperative complication was transient paresis of various cranial nerves. During a mean follow up of 6 years, only one tumor became malignant. Radical surgical resection should be the goal in treating these benign lesions, but if not possible, every effort should be made to minimize the amount of tumor tissue that remains.

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