Experience with a program for prevention of chronic renal failure in India

Mk, Mani

doi:10.1111/j.1523-1755.2005.09419.x

Cited by 86 publications

(77 citation statements)

References 1 publication

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“…The total cost amounts to 25 cents per capita of the study population. [42] A main tool to control CKD is patient cooperation in the treatment of underlying disease. Unfortunately, there is a lack of awareness in patients and general population.…”

Section: Gender-specific Prevalence Of Ckdmentioning

confidence: 99%

Screening for Decreased Renal Function in Taxi Drivers in Tehran, Iran

Mahdavi‐Mazdeh

Nazri

Hajghasemi³

et al. 2010

Renal Failure

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Background and objectives. The rapid increase in end stage renal disease (ESRD) prevalence, plus the enormous cost of treatment, necessitates an urgent approach to implement strategies to prevent development and progression of ESRD, especially in the developing world. Screening that leads to early identification and treatment has been recommended, as it may slow or prevent progression to a more expensive and disabling stage of the disease and thus may save lives as well as finite resources. Methods. In 2007, the Healthy City Office of Tehran municipality conducted a large-scale population-based crosssectional survey titled "Kidney Disease Screening of Taxi Drivers in Tehran." Taxi drivers or applicants of purchasing taxi participated in mentioned screening program in the last three months of 2007. Demographic data, blood pressure, and history of hypertension or smoking-and then in specific laboratories creatinine, lipid profile, complete blood count, fasting blood sugar, and urinalysis-have been checked. Results. The survey covered 31,999 people across Tehran (in a population of 12 million) during the study period. The mean and SD of age of participants was 43.77 ± 11.32 (range from18 to 86) years, and 98.4% (31,489) were male. Using the MDRD equation, overall prevalence of eGFR <60 mL/min/1.73 m 2 was 6.5%. However, the prevalence was 6.4% (1982/30949) in males in relation to 13.7% (69/503) in females. Mean and SD of BMI in males and females were 25.90 ± 3.91 and 26.48 ± 4.50 g, respectively. The overall prevalence of proteinuria (≥1+ proteinuria) was 0.6% in males vs. 1.8% in females in normal GFR group. Age, LDL cholesterol, hypertension, blood glucose, and BMI showed to be strong risk factors for low GFR. Education level did not show a significant correlation with low GFR. Discussion and conclusions. The findings of the study insist on the fact that CKD prevalence is significantly higher in old age, females, hypertensives, and uncontrolled diabetic patients. Our ability to decrease the incidence of ESRD is predicated on recognizing those patients with CKD and implementing all preventive strategies.

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Section: Gender-specific Prevalence Of Ckdmentioning

confidence: 99%

Screening for Decreased Renal Function in Taxi Drivers in Tehran, Iran

Mahdavi‐Mazdeh

Nazri

Hajghasemi³

et al. 2010

Renal Failure

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“…In countries where the living conditions are somewhat improving, and the income is increasing, a worrisome increase in CVD and diabetes is witnessed (34,35). In low-income countries, social and public health pilot experiences have shown that early detection of CKD is feasible at affordable costs (36,37). The next step is to provide aid to these countries and to also prove that inexpensive treatment for the prevention of CKD progression is possible.…”

Section: Figurementioning

confidence: 99%

Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes

Remuzzi

Benigni

Remuzzi³

2006

Journal of Clinical Investigation

538

419

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The incidence of chronic kidney diseases is increasing worldwide, and these conditions are emerging as a major public health problem. While genetic factors contribute to susceptibility and progression of renal disease, proteinuria has been claimed as an independent predictor of outcome. Reduction of urinary protein levels by various medications and a low-protein diet limits renal function decline in individuals with nondiabetic and diabetic nephropathies to the point that remission of the disease and regression of renal lesions have been observed in experimental animals and even in humans. In animal models, regression of glomerular structural changes is associated with remodeling of the glomerular architecture. Instrumental to this discovery were 3D reconstruction studies of the glomerular capillary tuft, which allowed the quantification of sclerosis volume reduction and capillary regeneration upon treatment. Regeneration of capillary segments might result from the contribution of resident cells, but progenitor cells of renal or extrarenal origin may also have a role. This review describes recent advances in our understanding of the mechanisms and mediators underlying renal tissue repair ultimately responsible for regression of renal injury.

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“…With an incidence of 151-163 per million population, End Stage Renal Disease (ESRD) is definitely growing at a fast rate [1]. It is also known that hypertensive and diabetic patients are at a higher propensity to develop kidney diseases and these account for 29.8% and 4.8% of the Indian population respectively [2,3,4]. A significant portion of the population, therefore, is at a growing risk of developing CKD.…”

Section: Introductionmentioning

confidence: 99%

Identification of unmet clinical needs in the field of nephrology – A modified bio-design approach

Arun-Kumar¹,

Sridhar²,

Chaturvedi³

et al. 2017

Med Devices Diagn Eng

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In India, the incidences and risks of Chronic Kidney Disease (CKD) have been rising alarmingly due to the rising prevalence of Hypertension and Diabetes patients. The treatment for CKD is unaffordable for most of the patients suffering from this condition. The lack of access to quality care in rural and suburban India further impacts the plight of CKD patients. These inconsistencies and gaps in effective treatment are equally present in most Nephrology related disorders. To address these issues, the authors used a modified version of the biodesign innovation process, originally developed by Stanford University, to identify unmet clinical needs in the field of nephrology from the perspective of developing new innovative medical devices to fit the evolving MedTech ecosystem in India. A multidisciplinary team, involving a doctor, an engineer and a designer, identified 54 unmet needs with significant negative outcomes from a 1 month clinical immersion held at a tertiary referral hospital in Southern India. 4 rounds of pre-caliberated filters were applied on these needs to identify the ten most compelling clinically validated needs for the phase of invention. This article talks about the modified biodesign process used, the top ten unmet clinical needs identified and the team's findings during the study.

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Experience with a program for prevention of chronic renal failure in India

Abstract: This model provides an effective method for prevention of chronic renal failure at the community level.

Cited by 86 publications

References 1 publication

Screening for Decreased Renal Function in Taxi Drivers in Tehran, Iran

Screening for Decreased Renal Function in Taxi Drivers in Tehran, Iran

Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes

Identification of unmet clinical needs in the field of nephrology – A modified bio-design approach

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