Experience of Treatment of Male Hypertension With Obesity, Fasting Hyperglycemia and Deficiency of Vitamin D

Filatova, T E.; Nizov, A A; Davydov, V. V.

doi:10.23888/pavlovj2017169-75

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…Так, по данным исследования ЭССЕ на территории РФ только треть женщин и 14,4% мужчин контролируют АД [4], а по материалам исследования РЕКВАЗА (Амбулаторно-поликлинический регистр кардиоваскулярных заболеваний в Рязанской области) только 25,6% кардиоваскулярных больных достигают цифр офисного АД<140/90 мм рт.ст. [5].…”

Section: Discussionunclassified

“…Развитие и прогрессирование сердечно-сосудистых заболеваний наиболее тесно связано с образом жизни больных и высокой распространенностью факторов риска [1,2]. Ведущим фактором риска является артериальная гипертензия, которую рассматривают и как отдельное заболевание -гипертоническую болезнь (ГБ) [3][4][5]. Успешный контроль за показателями артериального давления (АД) признан одной из наиболее эффективных профилактических стратегий по борьбе с кардиоваскулярными заболеваниями [1].…”

Section: Blood Pressure Remote Monitoring дистанционный мониторинг арunclassified

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Prospects for Blood Pressure Remote Monitoring in Hypertensive Patients in the Ryazan Region

Aksenova

Nizov

Selyavina

et al. 2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To study the effectiveness and benefits of blood pressure (BP) remote monitoring in outpatients with hypertension.Material and methods. The study included 100 patients with a verified diagnosis of hypertension, who didn’t achieve target BP pressure levels. The patients measured their BP twice a day over 6 months with facilities with automatic data transmission over GSM-channel to a remote monitoring center. BP parameters were being transmitted online to the remote monitoring center, where they were being processed and transferred to the personal account planner (created by the Web interface based on the software and hardware complex) of the attending physician and operator of the remote monitoring center. It is important that doctor received information only on clinically significant measurement results, based on which he determined the urgency of contact with the patient and the further tactics of his management.Results. No malfunctions in the work of communication facilities, technical failures in the software and hardware complex were registered over the entire period of the study. After 6 months of the monitoring it was possible to achieve target BP levels less than 135/85 mm Hg in 70% of patients. The proportion of patients with a high level of normal BP increased from 10% to 19%, while the proportion of patients with grade 1 and 2 of hypertension decreased significantly (from 33% to 7% and from 54% to 3%, respectively). At the beginning of telemedicine monitoring 3% of patients had stage 3 of hypertension, at the end of the study – 1%.Conclusion. The technology of telemedicine monitoring has shown itself as a simple, affordable and reliable way of management of outpatients with hypertension in conditions of real clinical practice. It was possible to achieve BP levels less than 135/85 mm Hg in 70% of patients by the method of remote outpatient monitoring. BP remote monitoring changed fundamentally the decision-making strategy of the patients management: it was not the patient who independently determined the need for consultation with a medical professional, but the attending physician made a decision on the method and urgency of contact with the patient on the basis of the data of objective monitoring indicators.

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Section: Discussionunclassified

Section: Blood Pressure Remote Monitoring дистанционный мониторинг арunclassified

Prospects for Blood Pressure Remote Monitoring in Hypertensive Patients in the Ryazan Region

Aksenova

Nizov

Selyavina

et al. 2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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“…Метаболический синдром (МС) -это синдромокомплекс, представляющий собой кластер традиционных и общих факторов риска развития кардиоваскулярных заболеваний -абдоминального ожирения, дислипидемии, артериальной гипертензии и гипергликемии [1][2][3]. Его компоненты связаны общим патогенезом -каскадом метаболических и гормональных нарушений, запускаемых инсулинорезистентностью, которой предшествует дисбаланс вегетативной нервной системы [4][5][6].…”

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Possibilities of use of metformin for correction of endothelial dysfunction and adaptation reserves of an organism in patients with metabolic syndrome

Nizov

Suchkova

Grivenko

et al. 2020

I.P. Pavlov Russian Medical Biological Herald

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Aim. To study possibilities of pharmaceutical correction of clinical laboratory parameters, of endothelial dysfunction and non-specific adaptation reserves in patients with metabolic syndrome (MS) through use of metformin. Materials and Methods. The three-month program involved 53 patients with MS rando-mized to two comparable groups. Patients of the control group were kept on individual low-calorie diet and practiced graduated exercises. Patients of the studied group, besides the mentioned program of modification of the lifestyle, took metformin. In all participants, anthropometric and clinical laboratory parameters were twice evaluated, total body composition, condition of vascular endothelium and non-specific adaptation reserves of an organism were analyzed. The extent of endothelial dysfunction was evaluated by the level of endothelin-1 and by parameters of photoplethysmographic examination, non-specific adaptation reserves by the method of analysis of the cardiac rhythm variability. Results. Metformin in complex with dietary therapy and physical exercises proved to be a safe medical drug for correction of components of MS and of endothelial dysfunction. Use of metformin in patients with MS in combination with dietary therapy and graduated physical exercises as compared to use of the program of modification of the lifestyle alone, leads to reduction in the body mass, waist circumference (in women) and of the total fat mass. Introduction of metformin into the program of complex therapy of patients with MS, provides more evident correction of the parameters of carbohydrate metabolism, reduction of endothelin-1 and stiffness index of the aortic wall, enhancement of parasympathetic regulation, than modification of the lifestyle alone. Conclusion. Use of metformin in the complex therapy of metabolic syndrome in comparison with the program of modification of the lifestyle, promotes a more significant reduction of the clinical laboratory parameters, of endothelial dysfunction and improves non-specific adaptation reserves of an organism.

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Treatment of metabolic syndrome in young patients with vitamin D deficiency

Alekseeva

2020

Terapevticheskii arkhiv

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Aim.The purpose of the study is to increase the effectiveness of treatment of metabolic syndrome (MS) in young patients with vitamin D deficiency. Materials and methods.The study involved 54 patients with MS and vitamin D deficiency (50% of women, 50% of men), aged 2044years. To assess the concentration of melatonin at a young age, a control group of 42 practically healthy volunteers with comparable demographic characteristics with no signs of MS was formed. Results.In patients with MS and vitamin D deficiency, there was a significant decrease in the average daily level of 6-sulfatoxymelatonin in the urine by 3.7 times, compared with the group of individuals without MS. Patients with MS and vitamin D deficiency (n=54) were randomly assigned to two groups with comparable clinical and demographic characteristics. Patients of the 1st group (n=27) observed dietary recommendations and took the drug Metformin at a dose of 1700 mg/day for 12 months. In the 2nd group (n=27), in addition to the one indicated in the 1st treatment group, correction of vitamin D deficiency was performed (a micelled preparation of cholecalciferol at a dose of 4000 IU/day, for 6 months, then 2000 IU/day for another 6 months) and the level of melatonin (melatonin preparation at a dose of 3 mg/day for 6 months). After treatment in young patients with MS, there was a significant change in the median of the studied parameters in all therapeutic groups, but more pronounced dynamics was observed in group 2 in terms of: WC in women, BMI, insulin resistance index, LDL cholesterol, TG, hs-CRP, hs-TNF-, IL-6, leptin. Conclusion.To increase the effectiveness of MS treatment in young patients with vitamin D deficiency, it is necessary to determine the level of melatonin (urinary 6-sulfatoxymelatonin) and, if it decreases, carry out correction of melatonin and 25 (OH) vitamin D in addition to the standard therapy of this syndrome.

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Experience of Treatment of Male Hypertension With Obesity, Fasting Hyperglycemia and Deficiency of Vitamin D

Cited by 3 publications

References 6 publications

Prospects for Blood Pressure Remote Monitoring in Hypertensive Patients in the Ryazan Region

Prospects for Blood Pressure Remote Monitoring in Hypertensive Patients in the Ryazan Region

Possibilities of use of metformin for correction of endothelial dysfunction and adaptation reserves of an organism in patients with metabolic syndrome

Treatment of metabolic syndrome in young patients with vitamin D deficiency

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