Experience of Targeted Antibacterial Therapy in a Patient With Multiple Organ Dysfunction Syndrome

Abstract

Objective : to analyze our own experience and literature data on the use of targeted antibacterial therapy in a patient with severe pneumonia and multiple organ dysfunction syndrome (MODS). Materials. The work presents a clinical case of successful treatment of a patient with community-acquired pneumonia, sepsis, and MODS, caused by multidrug resistant pathogens. Targeted antibiotic therapy was used during the treatment of the patient. Discussion . We have done a review of the literature and our own data on the antibiotic therapy for community-acquired pneumonia. The targeted antibacterial therapy in severe patients having a multidrug-resistant flora and MODS has the following features: it includes several drugs, is administered by courses, is often combined with antimycotic drugs, antibacterial drugs can be used via inhalation. The evaluation of clinical data, blood counts, as well as indicators of procalcitonin, C-reactive protein, and cholesterol provide substantial assistance during the monitoring of the therapy effectiveness. Conclusion. Among all the components of intensive care in a patient with community-acquired pneumonia, sepsis, and MODS, etiotropic therapy plays a leading role.