Experience in Grant-Management Gained by the Service of Operative Informational Support for Research at the Federal State Budget Institution «national Medical Research Center of Radiology» of the Health Ministry of Russian Fede-Ration in 2015-2016

Каприн, А. Д.; Savina, Nella P.; Starinsky, V. V; Мазнев, В. А.

doi:10.18821/1028-9984-2018-23-1-24-30

Cited by 17 publications

(26 citation statements)

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“…Рак яичников представляет собой одну из актуальнейших проблем онкогинекологии. В Российской Федерации в 2021 г. выявлено 11 584 новых случаев рака яичников [1]. Динамика заболеваемости незначительная: в период с 2013 по 2021 гг.…”

Section: актуальностьunclassified

“…произошло увеличение с 17 до 18 случаев на 100 тысяч населения. Удельный вес рака яичников в структуре смертности от злокачественных новообразований (ЗНО) среди женщин превышает 5,5 % [1] По данным доступной отечественной и зарубежной литературы у 65-70 % больных заболевание выявляется на III-IV стадии, что обусловлено отсутствием патогномоничной симптоматики и латентным течением рака яичников на ранних стадиях [1][2][3][4]. По данным отечественных авторов в 2021 г. радикальное хирургическое лечение рака яичников оказалось возможным менее, чем в половине выявленных случаев -48,8 % [1].…”

Section: актуальностьunclassified

“…3.1.6. Онкология, лучевая терапия ОБЗОР ПЕРСПЕКТИВЫ ВНУТРИБРЮШНОЙ АЭРОЗОЛЬНОЙ ХИМИОТЕРАПИИ ПОД ДАВЛЕНИЕМ ПРИ ЛЕЧЕНИИ ПЕРВИЧНОГО РАКА ЯИЧНИКОВ С ПЕРИТОНЕАЛЬНЫМ КАНЦЕРОМАТОЗОМ А. С. Дзасохов¹ , А. А. Костин², В. Л. Асташов 1 , А. В. Туриев 1 , А. Д. Усков 1 1. Московский областной онкологический диспансер, г.о.…”

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Perspectives of pressurized intraperitoneal aerosol chemotherapy in terms of primary ovarian cancer with peritoneal carcinomatosis treatment

Дзасохов

Kostin

Асташов

et al. 2023

Issled. prakt. med. (Print)

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The relevance of the problem of increasing the effectiveness of standard treatment of ovarian cancer is determined by the following characteristics of the disease: high one‑year mortality, high recurrence rate and unsatisfactory results of their treatment. Peritoneal carcinomatosis in ovarian cancer occurs in 65–70 % of cases. The standard modern approach to the treatment of ovarian cancer is a combination of surgical treatment and systemic intravenous chemotherapy. At the same time, more than 70 % of ovarian cancer cases are first diagnosed at stages III–IV. However, despite the successes in the field of surgery and drug treatment, the five‑year survival rate is no more than 24 % at the III and 4.6 % at the IV stage of the disease. One of the frontiers of ovarian cancer resistance to therapy is peritoneal carcinomatosis. Its resistance to therapy is due to the low bioavailability of cytostatics in metastases on the peritoneum to almost zero. In order to increase bioavailability, various forms of intra‑abdominal chemotherapy are used. The technique of pressurized intraperitoneal aerosol chemotherapy (PIPAC) has a number of advantages over other methods of intra‑abdominal antitumor treatment. These advantages include the uniform distribution of cytostatics over the peritoneum, the absence of penetration of cytostatics beyond the peritoneum, which allows PIPAC to be combined with systemic chemotherapy, low trauma and good tolerability of the procedure. PIPAC was implemented into clinical practice in 2011, and since then has been widely used in a number of foreign and domestic clinics. The conducted studies confirm the safety of the technique and its effectiveness against peritoneal carcinomatosis. The data of multicenter studies and the analysis of available literature data, as well as the successful own experience of PIPAC use create prerequisites for investigating the effectiveness of intra‑abdominal aerosol chemotherapy under pressure in relation to peritoneal carcinomatosis in ovarian cancer.

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Section: актуальностьunclassified

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Perspectives of pressurized intraperitoneal aerosol chemotherapy in terms of primary ovarian cancer with peritoneal carcinomatosis treatment

Дзасохов

Kostin

Асташов

et al. 2023

Issled. prakt. med. (Print)

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“…age-standardized incidence rates, ASIR) РЭ на 100 тыс. женщин в год был самым высоким в Европе (15,3) и Северной Америке (12,9), за которыми следуют Океания (10,6), Азия (6,2), Африка (5,1), Южная и Центральная Америка (4,9) [2,4].…”

Section: введение / Introductionunclassified

“…Рак эндометрия представляет собой серьезную проблему для здравоохранения и в России, где РЭ занимает второе место (7,0 % больных) по распространенности в структуре всех злокачественных новообразований [5,6]. Заболеваемость РЭ в России увеличивается в течение последних двух десятилетий, что, вероятно, связано с изменением факторов образа жизни Эффективность реабилитации после радикального хирургического лечения рака эндометрия Данная интернет-версия статьи была скачана с сайта http://www.gynecology.su.…”

Section: введение / Introductionunclassified

Rehabilitation effectiveness after radical surgical treatment of endometrial cancer

Блинов

Солопова

Ачкасов

et al. 2023

Akušerstvo, ginekologiâ i reprodukciâ

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Online breath analysis using metal oxide semiconductor sensors (electronic nose) for diagnosis of lung cancer

et al. 2019

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The analysis of exhaled breath is drawing a high degree of interest in the diagnostics of various diseases, including lung cancer. Electronic nose (E-nose) technology is one of the perspective approaches in the field due to its relative simplicity and cost efficiency. The use of an E-nose together with pattern recognition algorithms allow 'breath-prints' to be discriminated. The aim of this study was to develop an efficient online E-nose-based lung cancer diagnostic method via exhaled breath analysis with the use of some statistical classification methods. A developed multisensory system consisting of six metal oxide chemoresistance gas sensors was employed in three temperature regimes. This study involved 118 individuals: 65 in the lung cancer group (cytologically verified) and 53 in the healthy control group. The exhaled breath samples of the volunteers were analysed using the developed E-nose system. The dataset obtained, consisting of the sensor responses, was pre-processed and split into training (70%) and test (30%) subsets. The training data was used to fit the classification models; the test data was used for the estimation of prediction possibility. Logistic regression was found to be an adequate data-processing approach. The performance of the developed method was promising for the screening purposes (sensitivity-95.0%, specificity-100.0%, accuracy-97.2%). This shows the applicability of the gas-sensitive sensor array for the exhaled breath diagnostics. Metal oxide sensors are highly sensitive, low-cost and stable, and their poor sensitivity can be enhanced by integrating them with machine learning algorithms, as can be seen in this study. All experiments were carried out with the permission of the N.N. Petrov Research Institute of Oncology ethics committee no. 15/83 dated

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Experience in Grant-Management Gained by the Service of Operative Informational Support for Research at the Federal State Budget Institution «national Medical Research Center of Radiology» of the Health Ministry of Russian Fede-Ration in 2015-2016

Cited by 17 publications

References 0 publications

Perspectives of pressurized intraperitoneal aerosol chemotherapy in terms of primary ovarian cancer with peritoneal carcinomatosis treatment

Perspectives of pressurized intraperitoneal aerosol chemotherapy in terms of primary ovarian cancer with peritoneal carcinomatosis treatment

Rehabilitation effectiveness after radical surgical treatment of endometrial cancer

Online breath analysis using metal oxide semiconductor sensors (electronic nose) for diagnosis of lung cancer

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