Experience in food protein-induced enterocolitis syndrome in a paediatric allergy clinic

Ajami, Rasha Isabel Pérez; Sari, Silvia Karina Carrión; Mazas, Yolanda Aliaga; Calvo, Javier Boné; Abadía, María Isabel Guallar

doi:10.1016/j.anpede.2019.09.007

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…In our study, the main culprit food was CM, followed by hen's egg, and fish, which differs from the findings in other countries 11,15,17,22‐29 . The most frequent culprit food was fish (54%) in Greece 19 and Spain (70.6%), 27,30 rice in Australia 31‐33 and the USA, 18 and oats (34.5%) in Taiwan 34 .…”

Section: Discussioncontrasting

confidence: 95%

Food protein‐induced enterocolitis syndrome: A large French multicentric experience

Lemoine¹,

Colas

et al. 2022

Clinical & Translational All

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Background Food protein‐induced enterocolitis syndrome (FPIES) is a non‐IgE‐mediated food allergy, with potential dehydration secondary to vomiting. Differences exist regarding culprit foods, and age of tolerance depending on the country of origin. We aimed at describing the characteristics of a French population of children with FPIES, and define risk factors for failure during challenge. Methods Data from 179 children who were referred for FPIES in two pediatric tertiary centers between 2014 and 2020 were retrospectively collected. The diagnosis of FPIES was based on international consensus guidelines. Clinical characteristics, culprit food, and age at resolution were assessed. Tolerance was defined as no adverse reaction after OFC or accidental exposure. Results In the 192 described FPIES, the age at first symptoms was 5.8 months old. The main offending foods were cow's milk (60.3%), hen's egg (16.2%), and fish (11.7%). Single FPIES was observed in 94.4% and multiple FPIES in 5.6% of cases. The age at resolution of FPIES was 2.2 years old, and resolution occurred later for fish than for milk (2.9 years vs. 2.0, p = 0.01). Severe acute FPIES was a risk factor for delayed resolution (RR: 3.3 [1.2–9.2]), but not IgE sensitization. Performing a food challenge within 12 months after the first reaction increased the risk of failure (OR: 2.6 [1.1–6.6]). Conclusion In this French cohort of children with FPIES, the main culprit foods were ubiquitous. Rice, oat, and soy were rarely or not involved. Multiple FPIES was infrequent. Our data confirmed the overall good prognosis of FPIES, the later resolution of FPIES to fish and in the case of severe acute FPIES.

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Section: Discussioncontrasting

confidence: 95%

Food protein‐induced enterocolitis syndrome: A large French multicentric experience

Lemoine¹,

Colas

et al. 2022

Clinical & Translational All

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Frequency of positive oral food challenges and their outcomes in the allergy unit of a tertiary-care pediatric hospital

Ballini

Gavagni

Guidotti

et al. 2021

aei

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Introduction and objective: The oral food challenge (OFC) is the gold standard to diagnose food allergy (FA); however, it is not a procedure free from the risk of having significant allergic reactions, even life-threatening.The aims of our study were to evaluate the frequency of positive OFCs performed in chil-dren with a suspected diagnosis of IgE- and non-IgE–mediated (food protein–induced enterocolitis syndrome (FPIES)) FA and how the failed challenges were managed.Materials and methods: A retrospective chart review was done on all children who have had OFCs in a tertiary-care pediatric allergy unit from 2017 to 2019.Results: 682 patients were enrolled and 2206 challenges were performed: 2058 (93%) for IgE-mediated FA and 148 (7%) for FPIES. There were 262 (11.8%) challenge failures. The transfer to the emergency department was required 3 times (1.1%). None of the failed challenges resulted in death or hospitalization and 13.3% challenges did not require any treatment.Conclusions: Our findings confirm that food challenges can be performed safely in a specialized setting by well-trained personnel; all food challenge reactions, even the most serious, were reversible, thanks to a prompt recognition and treatment that generally did not worsen over time.

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Experience in food protein-induced enterocolitis syndrome in a paediatric allergy clinic

Cited by 2 publications

References 15 publications

Food protein‐induced enterocolitis syndrome: A large French multicentric experience

Food protein‐induced enterocolitis syndrome: A large French multicentric experience

Frequency of positive oral food challenges and their outcomes in the allergy unit of a tertiary-care pediatric hospital

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