Experience and Plasticity in the Central Nervous System

Horn, G.; Rose, Steven; Bateson, Patrick

doi:10.1007/978-1-349-03645-5_9

Cited by 11 publications

(13 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The strength of the imprinting memory was chosen as a model in the investigation of learning and memory because it was expected to involve measureable molecular and structural changes that could be linked to a precise learning event. Indeed cellular changes associated with imprinting were localized to an associative region of the forebrain in each hemisphere now called the intermediate medial mesopallium, IMM (Horn et al, 1973). These changes included increased RNA and protein synthesis (see Horn, 1985) and increased length of synaptic apposition.…”

Section: Lateralization Of Learning and Memorymentioning

confidence: 99%

Asymmetry of brain and behavior in animals: Its development, function, and human relevance

Rogers

2014

Genesis

115

View full text Add to dashboard Cite

Summary: Since the discovery of brain asymmetry in a wide range of vertebrate species, it has become possible to study development and expression of lateralized behavior accurately in well-controlled experiments. Several species have emerged as useful models for investigating aspects of lateralization. Discussed here are: (1) the influence of exposure to light during embryonic development on lateralization, (2) effects of steroid hormones on lateralization, (3) developmental changes in which hemisphere is controlling behavior, and (4) asymmetry in memory formation and recall. The findings have bearing on understanding the development of hemispheric specialization in humans and are likely to provide insight into dysfunctional behavior associated with weak or absent lateralization and impaired interhemispheric communication (e.g., autism, schizophrenia, and dyslexia). This review features research on chicks, pigeons, and zebrafish, with the addition of some recent evidence of lateralization in bees. Discoveries made using these species have highlighted the interaction between experience, hormones, and genetic factors during development, and have provided some of the first clear evidence of the advantage of having a lateralized brain. genesis 52:555-571,

show abstract

Section: Lateralization Of Learning and Memorymentioning

confidence: 99%

Asymmetry of brain and behavior in animals: Its development, function, and human relevance

Rogers

2014

Genesis

115

View full text Add to dashboard Cite

show abstract

“…This is also the location found for the elevated [3H]fucose incorporation; the muscarinic cholinergic changes have to date only been localized to the whole forebrain roof. However, the anterior forebrain roof is the site of those biochemical changes which we have found most closely associated with the learning of the imprinting stimulus, changes in RNA polymerase, RNA, and protein incorporation (Horn et al, 1973;Bateson et al, 1975;Rose, 1977). It is the region in which a 'hotspot', the medial hyperstriatum ventrale (MHV), has been localized using [ I4C ]uracil incorporation by autoradiography during imprinting by .…”

Section: R Mileusnic Et a Lmentioning

confidence: 98%

“…All of these observations are suggestive, though not conclusive, and the fact remains that the controls have not been made with the biochemical marker used in the present experiments. The logic of such experimental designs has been discussed elsewhere (Horn et al, 1973;Rose 1977;1980).…”

Section: R Mileusnic Et a Lmentioning

confidence: 99%

Passive Avoidance Learning Results in Region‐Specific Changes in Concentration of and Incorporation into Colchicine‐Binding Proteins in the Chick Forebrain

Mileusnic

Rose

Tillson

1980

Journal of Neurochemistry

View full text Add to dashboard Cite

Incorporation of [14T]leucine into trichloracetic acid‐precipitable material and tubulin‐enriched fractions, and total tubulin levels as determined by colchicine‐binding activity and retention on DE81 filter discs, were measured in various regions of the chick brain following training on a one‐trial passive avoidance task, suppression of pecking at a chromed bead as a consequence of the aversive taste of methylanthranilate. Radioactive pulse time was 0.5 h. The only brain region in which changes were found was the anterior forebrain roof, the same area in which biochemical changes in response to exposure of the birds to an imprinting stimulus have been observed previously. In the anterior forebrain roof the changes observed as a consequence of training were detectable at 0.5 and 24 h after the 10‐s training experience but not 48 h subsequently. One‐half hour after training, there were increases of the order of 20 or 30% in [14T]leucine incorporation into particulate and postmitochondrial TCA‐precipitable material and a tubulin‐enriched fraction purified as above. There were comparable increases in the total amount of colchicine‐binding activity. By 48 h, none of these increases were detectable. Subcellular fractionation of the particulate fraction showed that most of the increase of incorporation into the tubulin‐enriched fraction and in colchicine‐binding activity was present in the soluble content of the synaptosomes; there were no increases in either measure in the synaptic membrane fraction. The possible role of changed levels and turnover of tubulin in the plastic responses of the brain to learning experiences is discussed.

show abstract

“…Extensive evidence implicates protein synthesis in memory formation (for reviews see Horn et al ., 1973; Agranoff, 1980; Goelet et al ., 1986; Rose, 1991). Other studies have inquired whether particular proteins are involved in learning and memory, focusing on proteins that play important roles in neuronal function (Bailey et al ., 1992; Rose, 1995; Cavallaro et al ., 1997; Solomonia et al ., 1997; Silva et al ., 1998; Solomonia et al ., 1998; Orban et al ., 1999; Solomonia et al ., 2000).…”

Section: Introductionmentioning

confidence: 99%

Analysis of differential gene expression supports a role for amyloid precursor protein and a protein kinase C substrate (MARCKS) in long‐term memory

Solomonia

Morgan

Kotorashvili

et al. 2003

Eur J of Neuroscience

Self Cite

View full text Add to dashboard Cite

Previous work has identified the intermediate and medial part of the hyperstriatum ventrale (IMHV) as a region of the chick brain storing information acquired through the learning process of imprinting. We have examined in this brain region changes in expression of candidate genes involved in memory. Chicks were exposed to a rotating red box and the strength of their preference for it, a measure of learning, determined. Brain samples were removed approximately 24 h after training. Candidate genes whose expressions were different in IMHV samples derived from strongly imprinted chicks relative to those from chicks showing little or no learning were identified using subtractive hybridization. The translation products of two candidate genes were investigated further in samples from the left and right IMHV and from two other brain regions not previously implicated in imprinting, the left and right posterior neostriatum. One of the proteins was the amyloid precursor protein (APP), the other was myristoylated alanine rich C kinase substrate (MARCKS). In the left IMHV the levels of the two proteins increased with the strength of learning. The effects in the right IMHV were not significantly different from those in the left. There were no effects of learning in the posterior neostriatum. This is the first study to relate changes in the amounts of MARCKS and APP proteins to the strength of learning in a brain region known to be a memory store and demonstrates that the systematic identification of protein molecules involved in memory formation is possible.

show abstract

Experience and Plasticity in the Central Nervous System

Cited by 11 publications

References 92 publications

Asymmetry of brain and behavior in animals: Its development, function, and human relevance

Asymmetry of brain and behavior in animals: Its development, function, and human relevance

Passive Avoidance Learning Results in Region‐Specific Changes in Concentration of and Incorporation into Colchicine‐Binding Proteins in the Chick Forebrain

Analysis of differential gene expression supports a role for amyloid precursor protein and a protein kinase C substrate (MARCKS) in long‐term memory

Contact Info

Product

Resources

About