Homelessness is a condition of extreme poverty experienced globally. People experiencing homelessness are more likely than people who are stably housed to have negative health outcomes, including chronic health conditions, addiction, mental health issues, and exposure to physical and sexual violence. The public visibility of homeless people dealing with health disparities contributes to their dehumanization and stigmatization. Health communication interventions can improve homeless people's health outcomes by providing housing (e.g., through Housing First), ensuring access to mobile health resources, and reconsidering the cultures of institutions and organizations offering health services.