Expeditious isomerization of glucose to fructose in aqueous media over sodium titanate nanotubes

Kumar, Sandeep; Nepak, Devadutta; Kansal, Sushil Kumar; Elumalai, Sasikumar

doi:10.1039/c8ra04353a

Cited by 18 publications

(17 citation statements)

References 41 publications

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“…It seems the glucose became unstable due to isomerization to fructose over gold nanoparticles in aqueous media of BSA, glycine and cysteine. A similar report was published for sodium titanate nanotubes where glucose in aqueous media rapidly isomerized to fructose [20]. Also, the lower stability of compound A-AuNPs can be attributed to the neutral to alkaline pH used, which facilitated possible isomerization and epimerization in a reversible reaction of glucose to fructose and mannose respectively [24].…”

Section: Stability Of Aunpssupporting

confidence: 67%

The potential of chalcone-capped gold nanoparticles for the management of diabetes mellitus

Akinfenwa

Pearce

Omoruyi

et al. 2021

Surfaces and Interfaces

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Searching for new natural bioactive capping agents represent an urgent priority in the green synthesis of metal nanoparticles. Additionaly, the biosaftey of metal nanparticles is a major concern especially in medical applications. Recently, the use of pharmacollogicaly active natural products as capping agents has been deployed to avoid toxic effects during the nanoparticles preparation and to enhance their drugability compared with convential drugs. Helichrysum foetidum is a South African medicinal plant used in folk medicine for the treatment of different human pathologies, and it is known to contain a variety of bioactive compounds. Herein, the total extract and two pure chalcones, helichrysetin and helichrysin, isolated from the same plant were successfully used to synthesize quasi-monodispersed gold nanoparticles in the size range of 2-12 nm. The bio-evaluation of samples indicated that the AuNP/capping agent conjugates are biostable, and have different biological profiles from the total extract/pure compounds. The enzymatic inhibition assays showed significant inhibition by the total extract, helichrysetin and their gold nanoparticles. Interestingly, a similar activity was observed for glucose uptake in HEK293 treated cells. On the other hand, all the tested samples relatively demonstrated no cytotoxicity when tested against the HaCaT keratinocytes. In conclusion, the study demonstrated potential enhancement of glucose uptake in mammalian kidney cells, and inhibition of carbohydrate-hydrolysing enzymes by green synthesized gold nanoparticles of H. foetidum. It also provides a therapeutic appraisal of AuNPs/chalcones conjugate towards the development of antidiabetes drugs derived from H. foetidum and its gold nanoparticles.

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Section: Stability Of Aunpssupporting

confidence: 67%

The potential of chalcone-capped gold nanoparticles for the management of diabetes mellitus

Akinfenwa

Pearce

Omoruyi

et al. 2021

Surfaces and Interfaces

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“…Indeed, base catalysts such as hydrotalcite, NaOH, and KOH are well known to be effective catalysts of the chemical isomerization of glucose to produce fructose. For this reason, studies on 2 of 13 glucose isomerization using the base catalysts have actively been conducted [23][24][25][26]. Therefore, in this study, we examined the use of base catalysts for glucose isomerization.…”

Section: Introductionmentioning

confidence: 99%

Effect of the Solvent on the Basic Properties of Mg–Al Hydrotalcite Catalysts for Glucose Isomerization

Kwon

Cho

2020

Catalysts

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We suggested the existence of a relationship between the base properties of Mg–Al hydrotalcite catalysts and the solvents employed in the industrially important isomerization of glucose produce fructose. We prepared Mg–Al hydrotalcite catalysts with different Mg/Al atomic ratios to tune the basic properties of the catalyst. The prepared catalysts were used in the glucose isomerization conducted in various solvents. Experimental results confirmed that the catalysts exhibited different activities in the different solvents. We also implemented the Hammett indicator method, which allows to analyze the basic properties of the catalysts in various solvents. According to evidence, the basic properties of the catalysts varied substantially in different solvents. Notably, increases in the catalysts’ base properties matched the observed increases in fructose yield of the glucose isomerization. Consequently, we suggested that, in order to prepare efficient Mg–Al hydrotalcite catalysts for glucose isomerization, the interaction between the solvent used to conduct the reaction and the basic properties of the catalyst, which are in turn influenced by the solvent, should be considered.

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“…However, with concern over the problems arising from the use of homogenous base catalysts, research attention has been paid to heterogeneous base catalysts. So far, diverse materials such as single metal oxides [10][11][12][13], hydrotalcite [14][15][16][17][18], zeotype materials [18][19][20][21], metallosilicate [22], polymer-based materials [23,24] and supported amine (imine) [25,26] have been studied as solid base catalysts.…”

Section: Introductionmentioning

confidence: 99%

Ammonia-treated metal oxides as base catalysts for selective isomerization of glucose in water

Otomo

Fujimoto

Nagao

et al. 2019

Molecular Catalysis

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Expeditious isomerization of glucose to fructose in aqueous media over sodium titanate nanotubes

Abstract: Isomerization reaction of glucose to fructose over sodium titanate nanotubes (Na-TNTs) as a Lewis base catalyst was studied.

Cited by 18 publications

References 41 publications

The potential of chalcone-capped gold nanoparticles for the management of diabetes mellitus

The potential of chalcone-capped gold nanoparticles for the management of diabetes mellitus

Effect of the Solvent on the Basic Properties of Mg–Al Hydrotalcite Catalysts for Glucose Isomerization

Ammonia-treated metal oxides as base catalysts for selective isomerization of glucose in water

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