Expedited Wound Healing with Noncontact, Low-Frequency Ultrasound Therapy in Chronic Wounds

Kavros, Steven J.; Liedl, David; Boon, Andrea J.; Miller, J.; Hobbs, Julie; Andrews, Karen L.

doi:10.1097/01.asw.0000323546.04734.31

Cited by 67 publications

(56 citation statements)

References 6 publications

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“…The full complement of scheduled treatments available to patients during the 8 weeks of allocated treatment in the NLFU + SOC and SOC-only arms was 24 and 8, respectively (excluding treatments conducted in the final visit). Following randomisation, NLFU + SOC and SOC-only patients received a median (range) of 23 (20)(21)(22)(23)(24), and 8 (7-8) scheduled treatments during the study, respectively (Table 1). Each application of NLFU had a mean (SD) duration of 3⋅8 (1⋅0) minutes.…”

Section: Resultsmentioning

confidence: 99%

“…These randomised controlled trials (10,16,17) and several observational studies (mostly retrospective; 12,[19][20][21][22][23] have reported that treatment with NLFU improves wound healing. Kavros reported that significantly more patients with ischaemic wounds treated with NLFU achieved 50% wound closure at 12 weeks compared with those of SOC alone (63% versus 29%; P < 0⋅001).…”

Section: Key Messagesmentioning

confidence: 99%

See 1 more Smart Citation

Non‐contact low‐frequency ultrasound therapy compared with UK standard of care for venous leg ulcers: a single‐centre, assessor‐blinded, randomised controlled trial

White

Ivins

Wilkes

et al. 2015

International Wound Journal

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Abstract'Hard-to-heal' wounds are those which fail to heal with standard therapy in an orderly and timely manner and may warrant the use of advanced treatments such as non-contact low-frequency ultrasound (NLFU) therapy. This evaluator-blinded, single-site, randomised controlled trial, compared NLFU in addition to UK standard of care [SOC: (NLFU + SOC)] three times a week, with SOC alone at least once a week. Patients with chronic venous leg ulcers were eligible to participate. All 36 randomised patients completed treatment (17 NLFU + SOC, 19 SOC), and baseline demographics were comparable between groups. NLFU + SOC patients showed a −47% (SD: 38%) change in wound area; SOC, −39% (38%) change; and difference, −7⋅4% [95% confidence intervals (CIs) −33⋅4-18⋅6; P = 0⋅565]. The median number of infections per patient was two in both arms of the study and change in quality of life (QoL) scores was not significant (P = 0⋅490). NLFU + SOC patients reported a substantial mean (SD) reduction in pain score of −14⋅4 (14⋅9) points, SOC patients' pain scores reduced by −5⋅3 (14⋅8); the difference was −9⋅1 (P = 0⋅078). Results demonstrated the importance of high-quality wound care. Outcome measures favoured NLFU + SOC over SOC, but the differences were not statistically significant. A larger sample size and longer follow-up may reveal NLFU-related improvements not identified in this study.

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Section: Resultsmentioning

confidence: 99%

Section: Key Messagesmentioning

confidence: 99%

Non‐contact low‐frequency ultrasound therapy compared with UK standard of care for venous leg ulcers: a single‐centre, assessor‐blinded, randomised controlled trial

White

Ivins

Wilkes

et al. 2015

International Wound Journal

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“…28 This therapy has been shown to be a gentle, painless clinical protocol that is capable of stimulating cells at the wound bed to secrete more growth factors, 29 increase collagen synthesis, reduce inflammation, and induce vasodilation. 28 Although dentistry utilizes similar technologies routinely in debridement and disinfection of periodontal defects, there has been limited direct exploration of its utility in oral soft tissue healing. phatics, leading to improved wound healing.…”

Section: Ultrasoundmentioning

confidence: 99%

Biophysical Approaches for Oral Wound Healing: Emphasis on Photobiomodulation

Khan

Arany

2015

Advances in Wound Care

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“…Procedural guidance as in central line placement [24,25], diagnostic assessment as in the Focused Assessment with Sonography in Trauma (FAST) [26][27][28], thoracic cavitary ultrasonography to assess for pleural effusion, pneumothorax, or pneumonia [29,30], verification of tracheal airway placement [18], musculoskeletal diagnosis and treatment [14], cardiovascular applications [11,12,31], and gynecological screening [32,33] are now all commonplace in the clinical arena. New applications of ultrasound are presently being explored in the realms of thermal tumor ablation, hemorrhage control, nanotechnology, fracture healing, and noncontact wound therapy [34][35][36][37][38][39].…”

Section: Overview Of General Ultrasound Applications In Hemodynamic Amentioning

confidence: 99%

Clinician-performed ultrasound in hemodynamic and cardiac assessment: a synopsis of current indications and limitations

Kelly

Esteve

Papadimos

et al. 2015

Eur J Trauma Emerg Surg

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Accurate hemodynamic and intravascular volume status assessment is essential in the diagnostic and therapeutic management of critically ill patients. Over the last two decades, a number of technological advances were translated into a variety of minimally invasive or non-invasive hemodynamic monitoring modalities. Despite the promise of less invasive technologies, the quality, reliability, reproducibility, and generalizability of resultant hemodynamic and intravascular volume status data have been lacking. Since its formal introduction, ultrasound technology has provided the medical community with a more standardized, higher quality, broadly applicable, and reproducible method of accomplishing the above-mentioned objectives. With the advent of portable, hand-carried devices, the importance of sonography in hemodynamic and volume status assessment became clear. From basic venous collapsibility and global cardiac assessment to more complex tasks such as the assessment of cardiac flow and tissue Doppler signals, the number of real-life indications for sonology continues to increase. This review will provide an outline of the essential ultrasound applications in hemodynamic and volume status assessment, focusing on evidence-based uses and indications.

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Expedited Wound Healing with Noncontact, Low-Frequency Ultrasound Therapy in Chronic Wounds

Abstract: The rate of healing and complete closure of chronic wounds in patients improved significantly when MIST Therapy was combined with standard wound care.

Cited by 67 publications

References 6 publications

Non‐contact low‐frequency ultrasound therapy compared with UK standard of care for venous leg ulcers: a single‐centre, assessor‐blinded, randomised controlled trial

Non‐contact low‐frequency ultrasound therapy compared with UK standard of care for venous leg ulcers: a single‐centre, assessor‐blinded, randomised controlled trial

Biophysical Approaches for Oral Wound Healing: Emphasis on Photobiomodulation

Clinician-performed ultrasound in hemodynamic and cardiac assessment: a synopsis of current indications and limitations

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