Expedient assembly of densely functionalized indanonesvianickel-catalyzed alkene hydroacylation with methyl esters

Abstract

Given the chemical feedstock availability but intrinsic chemical inertness, the development of applicable cross-couplings with methyl esters as acyl electrophiles remains highly desirable and particularly challenging. Herein, we report a...

Electrochemical Oxidative Ring‐Opening Reactions of 2H‐Indazoles with Alcohols to Obtain Ortho‐alkoxycarbonylated Azobenzenes

“…These results showed that different position of substituent group had some effect on the reaction. It was worth noting that the compound 3 ha could be conveniently converted into 2-(4trifluoromethylphenyl)-3-indazolone (5 aa) [13] (Scheme 2), which was an investigational TRPV1 receptor antagonist for analgesics. [14] The yields of the products were decreased with increasing the steric hindrance of substituent.…”

“…[12] A method was developed to synthesize 2-azobenzonitrile motif via electrochemically-driven azidation reactions of 2H-indazoles with manganese as the catalyst (Scheme 1c). [13] Based on these efforts, we herein report an electrochemical method for ringopening reaction of 2H-indazoles with alcohols to synthesize ortho-alkoxycarbonylated azobenzene under metal-free reaction conditions.…”

Synthesis and Anti-Inflammatory Activity of N(2)-Arylindazol-3(2H)-One Derivatives: Copper-Promoted Direct N-Arylation via Chan–Evans–Lam Coupling

“…They have found application in diverse therapeutic areas, including anti-inflammatory agents, anti-hyperlipidemia agents, anti-tumor agents, anti-diabetic agents, and Transient Receptor Potential cation subfamily V member 1 (TRPV1) receptor antagonists [ 6 , 7 , 8 , 9 , 10 ]. The significance of indazol-3-ones as pharmacophores has heightened interest in the development of practical and convenient synthetic methods for generating N -substituted indazol-3-one derivatives [ 11 , 12 , 13 , 14 , 15 ], which is crucial because the introduction of different substituents at the N -position can significantly affect their biological properties. Therefore, the existence of efficient synthetic methods to prepare N -substituted indazol-3-ones is crucial in the discovery of new drug candidates.…”

“…receptor antagonists [6][7][8][9][10]. The significance of indazol-3-ones as pharmacophores has heightened interest in the development of practical and convenient synthetic methods for generating N-substituted indazol-3-one derivatives [11][12][13][14][15], which is crucial because the introduction of different substituents at the N-position can significantly affect their biological properties. Therefore, the existence of efficient synthetic methods to prepare Nsubstituted indazol-3-ones is crucial in the discovery of new drug candidates.…”

Palladium-Catalyzed Synthesis of Indanone via C–H Annulation Reaction of Aldehydes with Norbornenes

“…As a privileged structural motif, indanone represents an important class of heterocycle compounds that have been discovered in synthetic chemistry, biology, pharmacology, and materials chemistry . In recent years, the indanone skeleton has garnered increasing attention from researchers . Therefore, it is of considerable significance to develop efficient and simple methods for synthesizing indanone compounds.…”