Expedient access to N-alkylphthalimides via redox-neutral photocatalysed Giese-type reactions

Abstract

Photoredox-catalysed Giese-type reaction has emerged as a useful and powerful platform for the radical-based transformations. Herein, a novel protocol dealing with the preparation of N-alkylphthalimides has been successfully developed via...

Access to functionalized alkynylcyclopropanes via reductive radical-polar crossover-based reactions of 1,3-enynes with alkyl radicals

“…3 Notably, structurally diverse cyclopropanes can also be accessed from homoallylic (pseudo)halides and radicals, and the construction of cyclobutanes as well as medium-ring carbocycles and nitrogen heterocycles is also feasible via reactions of radicals with suitable (pseudo)halide-tethered alkenes (Scheme 1c). 3–5 Taking advantage of the mild reaction conditions and broad substrate scope, 6 a photoredox-neutral-catalysed radical addition/anionic cyclopropanation cascade reaction would be an especially attractive strategy for the preparation of cyclopropanes containing specific functional groups.…”

Regioselective Fluoroalkylarylation of Enamides Enabled by an Iron-Catalyzed Multicomponent Radical Cross-Coupling Strategy

“…However, a major drawback of these methods is the need for long reaction times, high temperatures, and/or limited substrate scope. Further, despite the importance of N -alkylated phthalimides and, in particular, widespread application in the practical synthesis of amines, , the use of N -vinylphthalimide in these transition-metal-catalyzed cross-coupling reactions has been severely limited. , …”