Expected and Unexpected Products from the Biochemical Oxidation of Bacterial Alkylquinolones with CYP4F11
Yue Shi,
Jianye Li,
Clemens Alexander Wolf
et al.
Abstract:2-Alkylquinolones are a class of microbial natural products primarily produced in the Pseudomonas and Burkholderia genera that play a key role in modulating quorum sensing. Bacterial alkylquinolones were synthesized and then subjected to oxidative biotransformation using human cytochrome P450 enzyme CYP4F11, heterologously expressed in the fission yeast Schizosaccharomyces pombe. This yielded a range of hydroxylated and carboxylic acid derivatives which had undergone ω-oxidation of the 2-alkyl chain, the struc… Show more
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