Expected advances in human fertility treatments and their likely translational consequences

Gleicher, Norbert

doi:10.1186/s12967-018-1525-4

Cited by 9 publications

(5 citation statements)

References 103 publications

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“…Gleicher suggests that maternal immunological tolerance of the fetus is a process of sequential steps of tolerance development, allowing for acceptance of a rapidly growing and immunologically differing paternal semi allograft [44]. Potentially, some RPL cases may be associated with insufficiency in the development of systemic tolerance pathways, which could result in the maternal immune system continuing to regard the fetus as foreign, mounting an abnormal allogenic immune response against it.…”

Section: Discussionmentioning

confidence: 99%

Detailed endometrial immune assessment of both normal and adverse reproductive outcome populations

Marron¹,

Walsh²,

Harrity

2018

J Assist Reprod Genet

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Flow cytometric endometrial evaluation has the ability to provide a rapid and objective analysis of lymphocyte subpopulations. The findings show significant variations in cellular proportions of immune cells across the patient categories relative to control tissue. The cell types involved suggest that a potential differential pro-inflammatory bias may exist in patients with a history of adverse reproductive outcomes. Immunological assessment in appropriate populations may provide insight into the underlying aetiology of some cases of reproductive failure.

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Section: Discussionmentioning

confidence: 99%

Detailed endometrial immune assessment of both normal and adverse reproductive outcome populations

Marron¹,

Walsh²,

Harrity

2018

J Assist Reprod Genet

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“…The majority were having sufficient income, and this expected since the new technological approaches to assisted fertilization are expensive. In this regard, Gleicher [26] emphasized the importance of looking for more affordable infertility treatment approaches.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of an Educational Program in Enhancing Infertile Women’s Psychological Health

Souilm¹,

Elkhalek²,

Hassan³

2018

AJNR

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Background: Infertility is a worldwide problem with negative impacts on psychological health of couples. Nurses have a crucial role in the mitigation of these problems. Aim of the study: To examine the effectiveness of a nursing intervention in enhancing infertile women's psychological health and improving associated disorders. Subjects and methods: The study was conducted in the outpatient department at Qena General Hospital using a one-group quasi-experimental design. It involved 90 infertile women attending the setting for management. An interview questionnaire form with four scales namely the General Health Questionnaire (GHQ), Narcissistic Personality Inventory, Experiences of Close Relationships-Revised (ECR-R), and the Defensive Style Questionnaire (DSQ-60) was used in data collection. The researcher designed and implemented by the researchers in the light of the needs identified in the pre-intervention assessment phase. The study was achieved through assessment, planning, implementation, and evaluation phases. Results: Women' age ranged between 21 and 47 years, mostly with primary infertility (80.0%). Statistically significant improvements were demonstrated at the post-intervention phase in all four domains of GHQ (p<0.001), and the mean total score increased from 39.6 to 68.0 (p<0.001). The total median narcissism personality score decreased from 24.50 before the intervention to 16.00 after the intervention (p<0.001). As for ECR-attachment scale, the median dropped from 4.16 to 3.11 (p<0.001). Similar statistically significant post-intervention improvements were revealed in the DSQ-60 scale. The multivariate analysis identified the study intervention as the main positive predictor of the GHQ score, a negative predictor of the narcissistic and ECR scores. Meanwhile, the study intervention was a positive predictor of the adapt DSQ domain whereas it was a negative predictor of the affect regulating domain score. Conclusion and recommendations: Infertile women suffer a number of psychological problems that are amenable to treatment through simple educational nursing interventions. Such educational endeavors should be implemented on a wide scale in all similar settings.

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“…Infertility is not just a medical condition; it is a deep-seated personal and socially embedded phenomenon. Whereas advancements in reproductive medicine have expanded treatment options [ 10 , 11 ], the psychological and emotional dimensions of infertility are yet to be fully understood. Fertility treatments can be financially burdensome, physically demanding, and emotionally draining on couples [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the psycho-social burden of infertility: Perspectives of infertile couples in Cape Coast, Ghana

Azize Diallo,

Anku,

Darkoa Oduro

2024

PLoS ONE

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Infertility is a complex and often sensitive issue with far-reaching psycho-social ramifications for couples and their families. This study therefore seeks to delve into the psycho-social burden of infertility in Cape Coast, a major city in Ghana. Specifically, we explored the impact of infertility on the psychological and social health of infertile couples receiving fertility treatment. It also delves into the strategies they adopt to cope with their conditions. The study employs a qualitative approach to inquiry using phenomenology as a study design to explore the experiences of the study participants. In-depth interviews were conducted using interview guides, voice recorded and transcribed verbatim. Both inductive and deductive/framework coding techniques were used to code the data leading to the generation of themes and sub-themes. The results show that most of the study participants dealing with infertility faced psychological burdens from different sources including their families, society and themselves. These burdens take a toll on their mental health, pushing them into a state of desperation and depression. It was, however, revealed that infertile couples are able to cope with the help of their family, spouses and the church. Curiously, some of them opt for withdrawal from social events as a coping mechanism. Infertility exerts an enormous negative psycho-social impact on affected couples, especially women. The family and society serve as the main sources of stressors for infertile couples. Therefore, programmes that are aimed at fertility treatment should deliberately consider addressing the psychosocial burden of infertility through education targeting actors, especially interpersonal-level actors.

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Expected advances in human fertility treatments and their likely translational consequences

Cited by 9 publications

References 103 publications

Detailed endometrial immune assessment of both normal and adverse reproductive outcome populations

Detailed endometrial immune assessment of both normal and adverse reproductive outcome populations

Effectiveness of an Educational Program in Enhancing Infertile Women’s Psychological Health

Exploring the psycho-social burden of infertility: Perspectives of infertile couples in Cape Coast, Ghana

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