Expansion technique for skin grafts (Meek technique) in the treatment of severely burned patients

Lari, Abdul Reda; Gang, R. K.

doi:10.1016/s0305-4179(00)00066-8

Cited by 51 publications

(29 citation statements)

References 14 publications

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“…The skin graft survival rate of the Meek group even reached 91.76%, and such a result was consistent with previous studies. Lari and Gang also found that 90% of the graft skin survived on the seventh day after surgery [7]. In our report, patients who received a Meek graft showed a significantly higher skin graft survival rate than those in the other two groups.…”

Section: Discussionsupporting

confidence: 64%

“…However, split skin grafting for extensively burned patients after their initial surgeries may be limited by the lack of autograft skin [6]. This factor may limit the excision of the eschar burn and delay the wound closure, thus leading to infection and septicemia [7]. To overcome this clinical barrier, various techniques have been developed to allow for skin graft expansion, such as Stamp skin transplantation [8], Microskin grafting [7], and the Meek skin graft technique [9].…”

Section: Introductionmentioning

confidence: 99%

“…This factor may limit the excision of the eschar burn and delay the wound closure, thus leading to infection and septicemia [7]. To overcome this clinical barrier, various techniques have been developed to allow for skin graft expansion, such as Stamp skin transplantation [8], Microskin grafting [7], and the Meek skin graft technique [9]. Some experts argue that cultivating granulation tissue could be a viable treatment method; however, the consequences of this procedure often include more granulation tissue, longer repair times, and scar hyperplasia, which often lead to severe scar contracture and dysfunction [10].…”

Section: Introductionmentioning

confidence: 99%

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Comparing the Curative Efficacy of Different Skin Grafting Methods for Third-Degree Burn Wounds

Gao

Chen

et al. 2017

Med Sci Monit

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BackgroundOur research purpose was to compare the curative efficacy of different skin grafting methods for treating third-degree burn wounds.Material/MethodsA total of 105 patients with third-degree burns were involved in this study. The burn wounds of these patients were treated using three different methods: Meek skin grafting, Stamp skin grafting, and Microskin grafting. Patients treated with different methods were placed in different groups. The skin graft survival rate, skin graft fusion time, wound healing time, total time of surgery, and 1% total body surface area (TBSA) treatment costs in each group were evaluated during and after the grafting procedures. After the operations, patients were followed up for 3 to 18 months in order to evaluate the postoperative outcomes.ResultsThe skin graft survival rate was significantly higher in the Meek group compared to the rates in the Stamp and Microskin groups (both P<0.01). In addition, the skin graft fusion time, wound healing time, and 1% TBSA treatment costs were significantly lower in the Meek group compared to those in the Stamp and Microskin groups (both P<0.01). Furthermore, the Meek group exhibited better results with respect to curative efficacy, scarring status, and joint activity in comparison to the other two groups (both P<0.05).ConclusionsThe Meek skin grafting method showed better clinical efficacy for treating large wound areas in third-degree burn patients compared to the Stamp and Microskin skin grafting methods.

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Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparing the Curative Efficacy of Different Skin Grafting Methods for Third-Degree Burn Wounds

Gao

Chen

et al. 2017

Med Sci Monit

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“…Autologous skin, harvested from nonburned regions of the patient’s own body, is preferred; however, in large burns, sufficient donor sites may not be available to achieve the necessary coverage even when meshed grafts are utilized (5, 6). In cases where sufficient autologous skin is not available, allogeneic skin from deceased donors may be grafted to provide temporary coverage.…”

mentioning

confidence: 99%

Lack of Cross-Sensitization Between α-1,3-Galactosyltransferase Knockout Porcine and Allogeneic Skin Grafts Permits Serial Grafting

et al. 2014

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Background The current standard of care for burns requiring operative treatment consists of early burn excision and autologous split-thickness skin grafting. However, in large burns, sufficient donor sites may not be available to achieve total coverage, necessitating temporary coverage with allogeneic human cadaver skin grafts or synthetic skin substitutes. A previous study from this laboratory demonstrated that skin grafts from alpha-1,3 galactosyltransferase knockout (GalT-KO) miniature swine enjoyed survival comparable to that of allogeneic skin grafts in baboons. Methods In the present study, we have evaluated the immune response against sequential GalT-KO and allogeneic skin grafts to determine whether such serial grafts could extend the period of temporary wound coverage before definitive grafting with autologous skin. Results We report that rejection of primary GalT-KO skin grafts led to an anti-xenogeneic humoral response with no evidence for sensitization to alloantigens nor acceleration of rejection of allogeneic skin grafts. Similarly, presensitization with allogeneic skin did not lead to accelerated rejection of xenogeneic skin. Conclusions These data suggest that GalT-KO skin grafts could provide an early first-line treatment in the management of severe burns that would not preclude subsequent use of allografts, and that serial grafting of GalT-KO skin and allogeneic skin could potentially be used to provide an extended period of temporary burn wound coverage.

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“…In order to overcome the deficiencies of these current treatments for stable refractory vitiligo and in reference to the Meek technique (11) in the treatment of severe burns, we proposed a modified method using smaller skin sheets (1 Â 1 mm 2 ) than the Meek one (3 Â 3 mm 2 ) as skin grafts to treat stable vitiligo. We adopted transplantation of autologous minigrafts with ultrapulsed CO 2 laser abrasion to treat a large area of stable vitiligo and we had satisfying clinical results (12).…”

Section: Introductionmentioning

confidence: 99%

Transplantation of autologous minigrafts for the treatment of stable vitiligo

Sun

Qian

et al. 2011

Journal of Dermatological Treatment

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Expansion technique for skin grafts (Meek technique) in the treatment of severely burned patients

Cited by 51 publications

References 14 publications

Comparing the Curative Efficacy of Different Skin Grafting Methods for Third-Degree Burn Wounds

Comparing the Curative Efficacy of Different Skin Grafting Methods for Third-Degree Burn Wounds

Lack of Cross-Sensitization Between α-1,3-Galactosyltransferase Knockout Porcine and Allogeneic Skin Grafts Permits Serial Grafting

Transplantation of autologous minigrafts for the treatment of stable vitiligo

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