Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index

Puhan, Milo A.; Garcia‐Aymerich, Judith; Frey, Martin; Riet, Gerben ter; Antó, Josep M.; Agustí, Àlvar; Gómez, Federico P.; Rodríguez-Roisin, Roberto; Moons, Karel G.M.; Kessels, Alphons G.H.; Held, Ulrike

doi:10.1016/s0140-6736(09)61301-5

Cited by 441 publications

(381 citation statements)

References 41 publications

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“…The BODE index is a prognostic scale that is typically used for research purposes 4 . However, the requirements for 6MWD greatly limit the use of this index 5 . The ADO index is a simple established prognostic scale that has a similar concept as the BODE index 5,15 .…”

Section: Discussionmentioning

confidence: 99%

“…These scales are based on the following measurements: body mass index (BMI), airflow obstruction, dyspnea, and exercise capacity index (BODE index); age, dyspnea and the airway obstruction index (ADO index); the health, activity, dyspnea, and obstruction score; the Briggs prognostic index; a classification and regression tree; and the incremental shuttle walking test, BMI, airflow obstruction, dyspnea, and exercise capacity index [4][5][6][7][8][9][10][11] . These scales allow us to evaluate the systemic presentation of COPD.…”

Section: Introductionmentioning

confidence: 99%

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Chronic obstructive pulmonary disease prognostic score: A new index

Horita¹,

Koblížek²,

Plutinsky³

et al. 2016

BIOMED PAP

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Background. The evaluation of chronic obstructive pulmonary disease (COPD) has been shifting from spirometry to focus on the patients' overall health. Despite the existence of many COPD prognostic scales, there remains a large gap for improvement, in particular a scale that incorporates the current focus on overall health. Methods. We proposed a new prognostic scale (the COPD Prognostic Score) through discussion among the authors based on published studies. Validation was retrospective, using data from the National Emphysema Treatment Trial. Results. The scores ranged from 0-16, where 16 indicated the poorest prognosis. We assigned 4 points each for forced expiratory volume in one second (%predicted), the modified Medical Research Council dyspnea scale, and age; 2 points for the hemoglobin level; and one point each for decreased activity and respiratory emergency admission in the last two years. The validation cohort included 607 patients and consisted of 388 men (73.9%) and 219 women (36.1%), mean age 67 ± 6 years and an average forced expiratory volume in one second (% predicted) of 27 ± 7%. A one-point increase in the score was associated with increased all-cause death, with a hazard ratio of 1.28 (95%CI: 1.21-1.36. P < 0.001). The areas under the receiver operating characteristic curves for two-year and five-year all-cause death for the new scale were 0.72 and 0.66, respectively. These values were higher than those given by the body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index and age, dyspnea, airway obstruction (ADO) index. Conclusion. The preliminary validation for a new COPD prognostic scale: the COPD Prognostic Score was developed with promising results thus far. Above mentioned 16-point score accurately predicted 2-year and 5-year all-cause mortality among subjects who suffered from severe and very severe COPD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic obstructive pulmonary disease prognostic score: A new index

Horita¹,

Koblížek²,

Plutinsky³

et al. 2016

BIOMED PAP

View full text Add to dashboard Cite

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“…The BODE index, 167 while increasingly important in staging COPD in secondary care practice, involves measurements not routinely available in primary care. The ADO index may be more practical, 168 and the DOSE index has been developed in primary care and intended for use in routine clinical practice. 169 A number of validated questionnaires measuring dyspnoea, 170,171 COPD control, 172,173 and impact on quality of life [174][175][176] International and national guidelines summarise and make therapeutic recommendations based on the extensive pharmacological and pulmonary rehabilitation evidence base.…”

Section: Managementmentioning

confidence: 99%

The International Primary Care Respiratory Group (IPCRG) Research Needs Statement 2010

Pinnock

Thomas

Tsiligianni

et al. 2010

Primary Care Respiratory Journal

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“…Several studies published over the past few decades have shown that level of lung function below predicted values is associated with an increased risk for mortality (1)(2)(3)(4)(5). The increase in risk has been demonstrated not only in clinical samples with established lung disease and associated impairment of lung function (1,2), but also in several general population samples with a wide distribution of lung function and without overt respiratory disease (3)(4)(5).…”

mentioning

confidence: 99%

“…The increase in risk has been demonstrated not only in clinical samples with established lung disease and associated impairment of lung function (1,2), but also in several general population samples with a wide distribution of lung function and without overt respiratory disease (3)(4)(5). In addition to lung function, sleep-disordered breathing (SDB) and measures of its severity, such as apnea-hypopnea index (AHI), have also been strongly associated with all-cause and cause-specific mortality (6)(7)(8).…”

mentioning

confidence: 99%

Influence of Lung Function and Sleep-disordered Breathing on All-Cause Mortality. A Community-based Study

Putcha

Crainiceanu

Norato

et al. 2016

Am J Respir Crit Care Med

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Rationale: Whether sleep-disordered breathing (SDB) severity and diminished lung function act synergistically to heighten the risk of adverse health outcomes remains a topic of significant debate.Objectives: The current study sought to determine whether the association between lower lung function and mortality would be stronger in those with increasing severity of SDB in a communitybased cohort of middle-aged and older adults.Methods: Full montage home sleep testing and spirometry data were analyzed on 6,173 participants of the Sleep Heart Health Study. Proportional hazards models were used to calculate risk for all-cause mortality, with FEV 1 and apnea-hypopnea index (AHI) as the primary exposure indicators along with several potential confounders.Measurements and Main Results: All-cause mortality rate was 26.9 per 1,000 person-years in those with SDB (AHI >5 events/h) and 18.2 per 1,000 person-years in those without (AHI ,5 events/h). For every 200-ml decrease in FEV 1 , all-cause mortality increased by 11.0% in those without SDB (hazard ratio, 1.11; 95% confidence interval, 1.08-1.13). In contrast, for every 200-ml decrease in FEV 1 , all-cause mortality increased by only 6.0% in participants with SDB (hazard ratio, 1.06; 95% confidence interval, 1.04-1.09). Additionally, the incremental influence of lung function on all-cause mortality was less with increasing severity of SDB (P value for interaction between AHI and FEV 1 , 0.004).Conclusions: Lung function was associated with risk for all-cause mortality. The incremental contribution of lung function to mortality diminishes with increasing severity of SDB.

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Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index

Cited by 441 publications

References 41 publications

Chronic obstructive pulmonary disease prognostic score: A new index

Chronic obstructive pulmonary disease prognostic score: A new index

The International Primary Care Respiratory Group (IPCRG) Research Needs Statement 2010

Influence of Lung Function and Sleep-disordered Breathing on All-Cause Mortality. A Community-based Study

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