2002
DOI: 10.1590/s1413-86702002000500007
|View full text |Cite
|
Sign up to set email alerts
|

Expansion of <FONT FACE=Symbol>gd</font><FONT FACE=Symbol> </font>T cells in patients infected with cutaneous leishmaniasis with and without glucantime therapy

Abstract: The expansion of gammadelta T cells in patients with active cutaneous leishmaniasis, with or without glucantime therapy, was investigated. Twenty patients with local cutaneous leishmaniasis including glucantime-treated (n=10) and untreated (n=10) patients were selected. The controls were healthy individuals (n=10) living in endemic areas. Whole blood was obtained and the T cell subpopulations were analyzed by flow cytometry. Significantly more gammadelta CD(3)(+) T cells were observed in untreated patients (15… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

0
4
0

Year Published

2006
2006
2024
2024

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(4 citation statements)
references
References 17 publications
0
4
0
Order By: Relevance
“…For a long time, the presence of γδ T cells has been found in lesions of L. braziliensis infected-patients with cutaneous and mucocutaneous leishmaniasis 30 , as well as enriched in human peripheral blood mononuclear cells (PBMCs) of L. major infected-patients 27 . Although γδ T cells were initially associated with the early stages of granuloma formation of L. braziliensis infection 26 , these cells were present in variable amounts in the CL, mucosal (ML) and disseminated cutaneous leishmaniasis (DisCL) lesions, regardless of the clinical characteristics (and duration) of the lesions 28 .…”
Section: Discussionmentioning
confidence: 99%
“…For a long time, the presence of γδ T cells has been found in lesions of L. braziliensis infected-patients with cutaneous and mucocutaneous leishmaniasis 30 , as well as enriched in human peripheral blood mononuclear cells (PBMCs) of L. major infected-patients 27 . Although γδ T cells were initially associated with the early stages of granuloma formation of L. braziliensis infection 26 , these cells were present in variable amounts in the CL, mucosal (ML) and disseminated cutaneous leishmaniasis (DisCL) lesions, regardless of the clinical characteristics (and duration) of the lesions 28 .…”
Section: Discussionmentioning
confidence: 99%
“…Little is known about the roles of these innate lymphocytes in Ascaris infection, but they are implicated in immunity against other parasites. γδ T cells are found in elevated numbers in the blood of patients with cutaneous leishmaniasis (Darabi et al ., 2002 ), Toxoplasma gondii (Prigione et al ., 2006 ) and Schistosoma infections (Schwartz et al ., 2014 ) and in the mesenteric lymph nodes of Schistosoma -infected mice (Yu et al ., 2014 ). γδ T cells numbers also increase after the acute phase of Plasmodium infection (Mamedov et al ., 2018 ) and are required for the induction of immunity against Plasmodium in vaccination studies in mice (Zaidi et al ., 2017 ).…”
Section: Discussionmentioning
confidence: 99%
“…It would also clearly be useful to know how the early treatment of CL affects the development of the beneficial Th1 response (Frankenburg et al, 1993b;Darabi et al, 2002;Machado et al, 2002). If chemotherapy given early in the disease process leads to parasite death, antigen release and subsequent immunization, it should be possible to prevent the development of clinical disease (i.e.…”
Section: Discussionmentioning
confidence: 99%
“…There is some worrying evidence indicating that chemotherapy may delay or even prevent the development of protective immunity (Frankenburg et al, 1993b;Darabi et al, 2002). This may explain why, in cases of CL caused by L. braziliensis, Machado et al (2002) were unable to prevent the ulceration of the developing lesions by the early administration of antimonials.…”
mentioning
confidence: 99%