Expansion of CD7low and CD7negative CD8 T-cell effector subsets in HIV-1 infection: correlation with antigenic load and reversion by antiretroviral treatment

Aandahl, Einar Martin; Quigley, Máire F.; Moretto, Walter J.; Moll, Markus; Gonzalez, Veronica D.; Sönnerborg, Anders; Lindbäck, Stefan; Hecht, Frederick M.; Deeks, Steven G.; Rosenberg, Michael; Nixon, Douglas F.; Sandberg, Johan K.

doi:10.1182/blood-2004-07-2540

Cited by 26 publications

(23 citation statements)

References 58 publications

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“…, and effector (CD27 Ϫ CD28 Ϫ CD7 low/neg CD45RA ϩ ) CD8 T cells (38,39). In the present study, we used five surface markers to define in detail the maturational status of CD16 ϩ CD8 T cells.…”

Section: Discussionmentioning

confidence: 99%

Elevated Numbers of FcγRIIIA+ (CD16+) Effector CD8 T Cells with NK Cell-Like Function in Chronic Hepatitis C Virus Infection

Björkström

Gonzalez

Malmberg

et al. 2008

The Journal of Immunology

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CTL are crucial in the defense against viral infections. In the course of investigating peripheral blood and intrahepatic CD8 T cells in patients with chronic hepatitis C virus (HCV) infection, we observed a significant population of CD8 T cells expressing the FcγRIIIA (CD16) receptor. This observation led us to characterize these cells with respect to their phenotype and function in a cohort of patients with chronic HCV infection as well as in healthy blood donors. On average, 10% of peripheral blood CD8 T cells from HCV-infected patients expressed CD16 compared with only a few percent in healthy donors. CD16+ CD8 T cells displayed a late-stage effector phenotype with high levels of perforin. These cells exhibited a restricted TCR profile suggesting underlying clonal expansion. Stimulation of CD16 on CD8 T cells evoked a vigorous response similar to that of CD16 stimulation in NK cells. Our data suggest that CD8 T cells, during chronic HCV infection in humans, continue to differentiate beyond defined stages of terminal effector cells, acquiring CD16 and NK cell-like functional properties.

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Section: Discussionmentioning

confidence: 99%

Elevated Numbers of FcγRIIIA+ (CD16+) Effector CD8 T Cells with NK Cell-Like Function in Chronic Hepatitis C Virus Infection

Björkström

Gonzalez

Malmberg

et al. 2008

The Journal of Immunology

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“…2A). Immune status and disease progression in HIV-infected subjects correlate with the down regulation of the early differentiation marker CD7 in CD8 T cells (Aandahl et al, 2004), and with the level of immune activation as determined by CD38 expression (Deeks et al, 2004;Giorgi et al, 1999;Hazenberg et al, 2003;Mocroft et al, 1997), in these cells. Interestingly, CD4 and CD8 T cells in the patient displayed an expression of these markers, as determined by flow cytometry, similar to that seen in healthy control subjects (n = 10) ( Fig.…”

Section: Case Reportmentioning

confidence: 96%

Spontaneous HCV clearance in HCV/HIV-1 coinfection associated with normalized CD4 counts, low level of chronic immune activation and high level of T cell function

Falconer

Gonzalez

Reichard

et al. 2008

Journal of Clinical Virology

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“…14,44,45 The generation of CD7 Ϫ T cells, as a consequence of repetitive mitogenic CD7 ϩ T cell stimulation, now provides a model for the observed accumulation of CD7 Ϫ T cells during chronic viral infections. Repetitive restimulation with viral antigens leads to extensive proliferation associated with repression of CD7 expression and differentiation into a late memory phenotype, which is associated with, reduced effector functions and a higher susceptibility to activation induced cell death upon antigen engagement.…”

Section: Cd7 ؊ T Cells Are Late Memory T Cells 553mentioning

confidence: 98%

“…6 CD4 ϩ CD7 Ϫ T cells, in contrast to CD4 ϩ CD7 ϩ T cells, increase in numbers in the peripheral blood during certain physiologic and pathologic conditions in vivo. For instance, circulating CD4 ϩ CD7 Ϫ T cells and CD8 ϩ CD7 Ϫ T cells increase in both percentages and absolute numbers during aging, 2,7,8 in certain inflammatory skin diseases, 9,10 rheumatoid arthritis, 11,12 chronic viral infections including HIV, 13,14 as well as in kidney transplant recipients. 15 In addition, CD4 ϩ CD7 Ϫ T cells seem to be involved in sustaining inflammatory processes in ectopic tertiary lymph nodes, 16,17 because they secrete a panel of cytokines that attract eosinophils and other reactive cells into inflammatory lesions.…”

Section: Introductionmentioning

confidence: 99%

CD7⁻T Cells are Late Memory Cells Generated from CD7⁺T Cells

Rappl

Schrama²,

Hombach³

et al. 2008

Rejuvenation Research

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CD7(-) T cells constitute a distinct subset within the CD4(+) and CD8(+) T cell populations; their developmental and functional relationship to the majority of CD7(+) T cells, however, remained so far unresolved. We here elucidate that CD7(-) cells represent aging T cells in late memory cell development characterized by a high activation threshold, low effector capacities, and high sensitivity to activation-induced cell death (AICD). In this regard, CD7(-) T cells highly express killer cell lectin-like receptor G1 (KLRG-1), harbor telomeres of shorter lengths, a decreased telomerase expression per cell, and less amounts of T cell receptor rearrangement excision circles (TRECs) compared to CD7(+) cells. CD7(-) T cells are generated in vitro from naive CD7(+) T cells upon repetitive TCR/CD28 engagement, a process that is unidirectional and requires multiple cell divisions. Consequently, clonal expansions of CD7(-) T cells in vivo are less frequent than of CD7(+) T cells, the former can be traced back to those of CD7(+) T cells.

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Expansion of CD7low and CD7negative CD8 T-cell effector subsets in HIV-1 infection: correlation with antigenic load and reversion by antiretroviral treatment

Cited by 26 publications

References 58 publications

Elevated Numbers of FcγRIIIA+ (CD16+) Effector CD8 T Cells with NK Cell-Like Function in Chronic Hepatitis C Virus Infection

Elevated Numbers of FcγRIIIA+ (CD16+) Effector CD8 T Cells with NK Cell-Like Function in Chronic Hepatitis C Virus Infection

Spontaneous HCV clearance in HCV/HIV-1 coinfection associated with normalized CD4 counts, low level of chronic immune activation and high level of T cell function

CD7⁻T Cells are Late Memory Cells Generated from CD7⁺T Cells

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Expansion of CD7low and CD7negative CD8 T-cell effector subsets in HIV-1 infection: correlation with antigenic load and reversion by antiretroviral treatment

Cited by 26 publications

References 58 publications

Elevated Numbers of FcγRIIIA+ (CD16+) Effector CD8 T Cells with NK Cell-Like Function in Chronic Hepatitis C Virus Infection

Elevated Numbers of FcγRIIIA+ (CD16+) Effector CD8 T Cells with NK Cell-Like Function in Chronic Hepatitis C Virus Infection

Spontaneous HCV clearance in HCV/HIV-1 coinfection associated with normalized CD4 counts, low level of chronic immune activation and high level of T cell function

CD7−T Cells are Late Memory Cells Generated from CD7+T Cells

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CD7⁻T Cells are Late Memory Cells Generated from CD7⁺T Cells