2004
DOI: 10.1182/blood-2004-07-2540
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Expansion of CD7low and CD7negative CD8 T-cell effector subsets in HIV-1 infection: correlation with antigenic load and reversion by antiretroviral treatment

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Cited by 26 publications
(23 citation statements)
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“…, and effector (CD27 Ϫ CD28 Ϫ CD7 low/neg CD45RA ϩ ) CD8 T cells (38,39). In the present study, we used five surface markers to define in detail the maturational status of CD16 ϩ CD8 T cells.…”
Section: Discussionmentioning
confidence: 99%
“…, and effector (CD27 Ϫ CD28 Ϫ CD7 low/neg CD45RA ϩ ) CD8 T cells (38,39). In the present study, we used five surface markers to define in detail the maturational status of CD16 ϩ CD8 T cells.…”
Section: Discussionmentioning
confidence: 99%
“…2A). Immune status and disease progression in HIV-infected subjects correlate with the down regulation of the early differentiation marker CD7 in CD8 T cells (Aandahl et al, 2004), and with the level of immune activation as determined by CD38 expression (Deeks et al, 2004;Giorgi et al, 1999;Hazenberg et al, 2003;Mocroft et al, 1997), in these cells. Interestingly, CD4 and CD8 T cells in the patient displayed an expression of these markers, as determined by flow cytometry, similar to that seen in healthy control subjects (n = 10) ( Fig.…”
Section: Case Reportmentioning
confidence: 96%
“…14,44,45 The generation of CD7 Ϫ T cells, as a consequence of repetitive mitogenic CD7 ϩ T cell stimulation, now provides a model for the observed accumulation of CD7 Ϫ T cells during chronic viral infections. Repetitive restimulation with viral antigens leads to extensive proliferation associated with repression of CD7 expression and differentiation into a late memory phenotype, which is associated with, reduced effector functions and a higher susceptibility to activation induced cell death upon antigen engagement.…”
Section: Cd7 ؊ T Cells Are Late Memory T Cells 553mentioning
confidence: 98%
“…6 CD4 ϩ CD7 Ϫ T cells, in contrast to CD4 ϩ CD7 ϩ T cells, increase in numbers in the peripheral blood during certain physiologic and pathologic conditions in vivo. For instance, circulating CD4 ϩ CD7 Ϫ T cells and CD8 ϩ CD7 Ϫ T cells increase in both percentages and absolute numbers during aging, 2,7,8 in certain inflammatory skin diseases, 9,10 rheumatoid arthritis, 11,12 chronic viral infections including HIV, 13,14 as well as in kidney transplant recipients. 15 In addition, CD4 ϩ CD7 Ϫ T cells seem to be involved in sustaining inflammatory processes in ectopic tertiary lymph nodes, 16,17 because they secrete a panel of cytokines that attract eosinophils and other reactive cells into inflammatory lesions.…”
Section: Introductionmentioning
confidence: 99%