2017
DOI: 10.3389/fimmu.2017.00528
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Expansion of CD25-Negative Forkhead Box P3-Positive T Cells during HIV and Mycobacterium tuberculosis Infection

Abstract: Tuberculosis (TB) and HIV alter the immune system, and coinfected (HIV-TB) individuals usually present deregulations of T-lymphocytic immune response. We previously observed an increased frequency of “unconventional” CD4+CD25−FoxP3+ Treg (uTreg) population during HIV-TB disease. Therefore, we aimed to explore the phenotype and function of uTreg and conventional CD4+CD25+FoxP3+ Treg subsets (cTreg) in this context. We evaluated the expression of CD39, programmed cell death protein 1 (PD1), glucocorticoid-induce… Show more

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Cited by 25 publications
(25 citation statements)
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“…uTregs, CD25-FoxP3+) was also analyzed. This is a CD4 + FoxP3+ T cell population with undetectable levels of CD25 [25] that exerts an inhibitory capacity supressing proliferation and cytokine production from effector T cells [26]. We found that in HIV-TB patients uTregs were expanded, as reported elsewhere ( Fig.…”
Section: Characterization Of Cd4 + Th Subpopulations In Hiv-tb and Hdsupporting
confidence: 86%
See 1 more Smart Citation
“…uTregs, CD25-FoxP3+) was also analyzed. This is a CD4 + FoxP3+ T cell population with undetectable levels of CD25 [25] that exerts an inhibitory capacity supressing proliferation and cytokine production from effector T cells [26]. We found that in HIV-TB patients uTregs were expanded, as reported elsewhere ( Fig.…”
Section: Characterization Of Cd4 + Th Subpopulations In Hiv-tb and Hdsupporting
confidence: 86%
“…Our results indicated that this population is associated with an unfavorable result, but differences may be due to a different recruited cohort and that the authors studied Ki67+ cells CD4 + T cells [36]. Otherwise, our previous results observed an increased frequency of uTregs during HIV-TB disease [25] and described that this population exerts regulatory functions, in spite of an altered surface expression of markers and differences in cytokine production [37]. In line with this, lower Th1/uTregs ratio was observed in those patients who were not on HAART and who developed a disseminated TB infection.…”
Section: Discussionmentioning
confidence: 57%
“…CD39 expression is primarily expressed by immune-suppressive FOXP3 + Tregs (24,31). FOXP3/CD39 coexpression has been reported on Tregs from patients with chronic infections such as coinfection by HIV and tuberculosis (32) or was correlated with the progression of HBV infection (33). This suggests some common features between persistent viral chronic infections.…”
Section: Discussionmentioning
confidence: 97%
“…To this end, it was discovered in 2001 that a mutation in the forkhead box P3 (Foxp3) gene, was directly linked to T cell proliferation, activation, and multisystem autoimmunity. 15 12 Several years after this gene was linked to immunosuppression, it was shown to be specifically expressed in CD4 + CD25 + cells, 13 and retroviral transduction of the gene into naive CD4 + CD25 − T cells results in a Treg phenotype and suppressive function in vitro and in vivo.…”
Section: Iscovery Of Reg Ul Atory T Cell Smentioning
confidence: 99%
“…14 Since then, Foxp3 has emerged as a critical tenant of Treg function and serves as a more reliable marker than CD25, which we now know to be absent on the surface of some fully functioning CD4 + Foxp3 + Tregs (termed "unconventional Tregs"). 15…”
Section: Iscovery Of Reg Ul Atory T Cell Smentioning
confidence: 99%