Expansion of CD11b+Ly6Ghigh and CD11b+CD49d+ myeloid cells with suppressive potential in mice with chronic inflammation and light-at-night-induced circadian disruption

Perfilyeva, Yuliya V.; Abdolla, Nurshat; Ostapchuk, Yekaterina O.; Tleulieva, Raikhan; Krasnoshtanov, Vladimir C.; Belyaev, Nikolai N.

doi:10.1007/s00011-017-1052-4

Cited by 13 publications

(7 citation statements)

References 80 publications

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“…CD115 expression levels correlate with Treg expansion induced by MDSCs (16–18). IL-4R expression is closely associated with CD8 + T cell inhibition (19), whereas CD49 + MDSCs reflect MO-MDSCs suppressive toward both antigen-specific and non-specific T cell proliferation (8, 20–22).…”

Section: Mdscsmentioning

confidence: 99%

Roles of Myeloid-Derived Suppressor Cell Subpopulations in Autoimmune Arthritis

Zhu

Wang

et al. 2018

Front. Immunol.

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Emerging evidence suggests the promise of the use of myeloid-derived suppressor cells (MDSCs) in inflammatory disorders based on their unique immune-intervention properties. However, the roles of MDSCs in autoimmune arthritis are not completely understood. Indeed, their immunosuppressive functions in arthritic conditions remain controversial, with heterogeneity among MDSCs and differential effects among subpopulations receiving much attention. As a result, it is necessary to determine the roles of MDSC subpopulations in autoimmune arthritis to clarify their diagnostic and therapeutic potential. Interestingly, in the inflammation niche of autoimmune arthritis, each MDSC subpopulation can exhibit both alternatives of a given characteristic. Moreover, polymorphonuclear MDSCs (PMN-MDSCs) are likely to be more suppressive and stable compared with monocytic MDSCs (MO-MDSCs). Although various important cytokines associated with the differentiation of MDSCs or MDSC subpopulations from immature myeloid precursors, such as granulocyte colony-stimulating factor (G-CSF), have been largely applied in external inductive systems, their roles are not entirely clear. Moreover, MDSC-based clinical treatments in rheumatoid arthritis (RA) continue to represent a significant challenge, as also reported for other autoimmune diseases. In this review, we describe the effects and actions of MDSC subpopulations on the development of autoimmune arthritis and analyze several types of MDSC-based therapeutic strategies to provide comprehensive information regarding immune networks and a foundation for more effective protocols for autoimmune arthritis.

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Section: Mdscsmentioning

confidence: 99%

Roles of Myeloid-Derived Suppressor Cell Subpopulations in Autoimmune Arthritis

Zhu

Wang

et al. 2018

Front. Immunol.

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“…The disruption of circadian rhythms due to LL has also been demonstrated to promote tumorigenesis and adversely affect chronic inflammatory processes [ 152 , 159 , 160 ]. Rats implanted with C6 tumor cells and exposed to LL for 5 weeks exhibited faster tumor growth and increased tumor infiltration with macrophages compared to controls in the LD regime [ 152 ].…”

Section: Effects Of Circadian Disruption On Innate Immunitymentioning

confidence: 99%

“…In addition, recent evidence suggests that myeloid-derived suppressor cells are associated with a poor prognosis in cancer [ 161 ]. In the mouse model of chronic inflammation, 4-week LL potentiated the accumulation of myeloid-derived suppressor cells (granulocytic CD11b + Ly6G high and monocytic CD11b + CD49d + cell subsets) in the spleen and elevated IL-6 levels in the circulation [ 160 ].…”

Section: Effects Of Circadian Disruption On Innate Immunitymentioning

confidence: 99%

Circadian Disruption and Consequences on Innate Immunity and Inflammatory Response

Jerigova

Zeman

Okuliarova

2022

IJMS

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Circadian rhythms control almost all aspects of physiology and behavior, allowing temporal synchrony of these processes between each other, as well as with the external environment. In the immune system, daily rhythms of leukocyte functions can determine the strength of the immune response, thereby regulating the efficiency of defense mechanisms to cope with infections or tissue injury. The natural light/dark cycle is the prominent synchronizing agent perceived by the circadian clock, but this role of light is highly compromised by irregular working schedules and unintentional exposure to artificial light at night (ALAN). The primary concern is disrupted circadian control of important physiological processes, underlying potential links to adverse health effects. Here, we first discuss the immune consequences of genetic circadian disruption induced by mutation or deletion of specific clock genes. Next, we evaluate experimental research into the effects of disruptive light/dark regimes, particularly light-phase shifts, dim ALAN, and constant light on the innate immune mechanisms under steady state and acute inflammation, and in the pathogenesis of common lifestyle diseases. We suggest that a better understanding of the mechanisms by which circadian disruption influences immune status can be of importance in the search for strategies to minimize the negative consequences of chronodisruption on health.

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“…Similarly, in male F344 rats, a single night of housing in ALAN (200 lx) suppressed the nocturnal increase in number and cytotoxic activity of splenic NK cells [ 56 ]. In contrast, CD-1 mice house in constant illumination of 750 lx ALAN for 4 weeks demonstrated significantly increased granulocytic CD11b + Ly6G high and monocytic CD11b + CD49 d+ myeloid subsets within the spleen [ 57 ]. ALAN increased the plasma bacterial killing capacity in male Nile grass rats ( Arvicanthis niloticus ) housed in 5 lx of light at night for 3 weeks [ 58 ].…”

Section: Alan and Innate Immune Functionmentioning

confidence: 99%