Expansion of a subset of CD14highCD16negCCR2low/neg monocytes functionally similar to myeloid-derived suppressor cells during SIV and HIV infection

Gama, Lúcio; Shirk, Erin N.; Russell, Julia N.; Carvalho, Karina I.; Li, Ming; Queen, Suzanne E.; Kalil, Jorge; Zink, M. Christine; Clements, Janice E.; Kallas, Esper G.

doi:10.1189/jlb.1111579

Cited by 57 publications

(49 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In most cases, these cells displayed a monocytic-like phenotype (8,50,122), however, a granulocytic-like phenotype was observed in one study (155). The mechanism of suppression of T cell responses by M-MDSCs from SIV-infected macaques has not been definitively determined, but may be linked to high iNOS expression by the MDSCs (49,146).…”

Section: Retrovirusesmentioning

confidence: 91%

“…Collectively, these data suggest that MDSC-LCs derived during HSV infection may be able to utilize several mechanisms to suppress inflammation. (49,122,155). Similarly, antiviral therapy decreased MDSC frequencies in the blood of HCV patients (14).…”

Section: Dna Virusesmentioning

confidence: 94%

“…In many viral diseases, MDSC numbers correlated with pathogenesis, including in HIV (24,25,122,155), LP-BM5 (53), and more than half of the reported studies in HCV (14,52,170). Conversely, antiviral therapies, which decrease pathology, were associated with decreased MDSC numbers in HCV (14) and HIV/SIV (49,122,155). One of the roles of MDSCs in pathogenesis is to decrease antiviral immunity, possibly to limit immunopathological damage.…”

Section: Direct Targeting Of Mdscs In Vivomentioning

confidence: 99%

See 2 more Smart Citations

The Role of Myeloid-Derived Suppressor Cells in Viral Infection

2017

View full text Add to dashboard Cite

Myeloid-derived suppressor cells (MDSCs) are heterogeneous immature myeloid cells that are well described as potent immune regulatory cells during human cancer and murine tumor models. Reports of MDSCs during viral infections remain limited, and their association with immunomodulation of viral diseases is still being defined. Here, we provide an overview of MDSCs or MDSC-like cells identified during viral infections, including murine viral models and human viral diseases. Understanding the similarities and/or differences of virally induced versus tumor-derived MDSCs will be important for designing future immunotherapeutic approaches.

show abstract

Section: Retrovirusesmentioning

confidence: 91%

Section: Dna Virusesmentioning

confidence: 94%

Section: Direct Targeting Of Mdscs In Vivomentioning

confidence: 99%

See 1 more Smart Citation

The Role of Myeloid-Derived Suppressor Cells in Viral Infection

2017

View full text Add to dashboard Cite

show abstract

“…+/2 CD16 ++ nonclassical subsets are increased, particularly at the AIDS stage, and newly recruited and dividing monocytes/macrophages are found in SIV encephalitis lesions (46)(47)(48)(49)(50).…”

Section: Ouse Cd8amentioning

confidence: 99%

TLR3–Responsive, XCR1+, CD141(BDCA-3)+/CD8α+-Equivalent Dendritic Cells Uncovered in Healthy and Simian Immunodeficiency Virus–Infected Rhesus Macaques

Dutertre¹,

Jourdain²,

Rancez³

et al. 2014

The Journal of Immunology

View full text Add to dashboard Cite

In mice, CD8α+ myeloid dendritic cells (mDC) optimally cross-present Ags to CD8+ T cells and respond strongly to TLR3 ligands. Although equivalent DC have been identified by comparative genomic analysis and functional studies in humans as XCR1+CD141 (BDCA-3)+Clec9A+cell adhesion molecule 1+ mDC, and in sheep as CD26+ mDC, these cells remained elusive in nonhuman primates. To remedy this situation, we delineated precisely DC and monocyte populations by 12-color flow cytometry and transcriptomic analyses in healthy rhesus macaques. We identified a new mDC population, with strong phenotypic and transcriptional homology to human CD141+ and murine CD8α+ mDC, including XCR1 membrane expression as a conserved specific marker. In contrast, high CD11c expression was not characteristic of mDC in macaques, but of CD16+ monocytes. Like their human and murine homologs, simian XCR1+ mDC had much stronger responses to TLR3 stimulation than other myeloid cells. The importance of this new mDC population was tested in SIVmac251 infection, the most relevant animal model for pathogenic HIV-1 infection and vaccination. This population increased sharply and transiently during acute infection, but was reduced in blood and spleen during advanced disease. The identification of XCR1+ mDC in rhesus macaques opens new avenues for future preclinical vaccinal studies and highlights XCR1 as a prime candidate for targeted vaccine delivery.

show abstract

“…Cells were stained and fixed as described above and as previously described. 62 Samples were analyzed using a BD LSRFortessa or FACSCalibur cytometer and Diva software version 6.1.3 (Becton Dickinson). FACS data were analyzed using FlowJo version 9.5.1 (FlowJo, Ashland, OR).…”

Section: Immunostaining and Flow Cytometry Of Pbmc And Spleen Single-mentioning

confidence: 99%

Splenic Damage during SIV Infection

Williams

Engle

Shirk

et al. 2016

The American Journal of Pathology

Self Cite

View full text Add to dashboard Cite

Expansion of a subset of CD14highCD16negCCR2low/neg monocytes functionally similar to myeloid-derived suppressor cells during SIV and HIV infection

Abstract: Characterization of a novel monocyte subset that suppresses CD8+ proliferation during HIV and SIV infection.

Cited by 57 publications

References 69 publications

The Role of Myeloid-Derived Suppressor Cells in Viral Infection

The Role of Myeloid-Derived Suppressor Cells in Viral Infection

TLR3–Responsive, XCR1+, CD141(BDCA-3)+/CD8α+-Equivalent Dendritic Cells Uncovered in Healthy and Simian Immunodeficiency Virus–Infected Rhesus Macaques

Splenic Damage during SIV Infection

Contact Info

Product

Resources

About