Expansion and characterization of cancer stem-like cells in squamous cell carcinoma of the head and neck

Okamoto, Atsushi; Chikamatsu, Kazuaki; Sakakura, Koichi; Hatsushika, Kyosuke; Takahashi, Goro; Masuyama, Keisuke

doi:10.1016/j.oraloncology.2008.10.003

Cited by 148 publications

(147 citation statements)

References 30 publications

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“…The addition of growth factors guides them toward proliferation and formation of cell aggregates that are termed tumor spheres (Allegra et al, 2012). Okamoto et al reported that CSCs isolated from cell lines from carcinoma of the oral cavity were highly capable of forming spheres and expressed high levels of CD44 (Okamoto et al, 2009). Chiou et al (2008) studied two cell lines and primary tumors of the oral cavity and showed that the isolated CSCs had a high capacity to form tumor spheres and expressed high levels of CD133 .…”

Section: Methods Of Identification Of Cancer Stem Cellsmentioning

confidence: 99%

“…In HNSCC, a higher percentage of CD44+ cells in a patient's primary tumor has been shown to be associated with higher rates of treatment failure, while cells expressing the putative CSC markers CD44, CD24, Oct4, and integrin-β1were associated with poor outcomes following radiotherapy (Joshua et al, 2012;Koukourakis et al, 2012). CSC, as defined by CD44 expression, have a greater resistance to pro-apoptotic stimuli (TNF-α and anti-Fas antibody) and a greater capacity for resistance to chemotherapeutic agents compared to non-CSC (Chikamatsu et al, 2012;Okamoto et al, 2009).…”

Section: Recurrence and Resistance To Therapymentioning

confidence: 99%

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Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: A Review

Satpute

Hazarey²,

Ahmed³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Research indicates that a small population of cancer cells is highly tumorigenic, endowed with the capacity for self-renewal, and has the ability to differentiate into cells that constitute the bulk of tumors. These cells are considered the ''drivers'' of the tumorigenic process in some tumor types, and have been named cancer stem cells (CSC). Epithelial-mesenchymal transition (EMT) appears to be involved in the process leading to the acquisition of stemness by epithelial tumor cells. Through this process, cells acquire an invasive phenotype that may contribute to tumor recurrence and metastasis. CSC have been identified in human head and neck squamous cell carcinomas (HNSCC) using markers such as CD133 and CD44 expression, and aldehyde dehydrogenase (ALDH) activity. Head and neck cancer stem cells reside primarily in perivascular niches in the invasive fronts where endothelial-cell initiated events contribute to their survival and function. Clinically, CSC enrichment has been shown to be enhanced in recurrent disease, treatment failure and metastasis. CSC represent a novel target of study given their slow growth and innate mechanisms conferring treatment resistance. Further understanding of their unique phenotype may reveal potential molecular targets to improve therapeutic and survival outcomes in patients with HNSCC. Here, we discuss the state-of-the-knowledge on the pathobiology of cancer stem cells, with a focus on the impact of these cells on head and neck tumor progression, metastasis and recurrence due to treatment failure.

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Section: Methods Of Identification Of Cancer Stem Cellsmentioning

confidence: 99%

Section: Recurrence and Resistance To Therapymentioning

confidence: 99%

Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: A Review

Satpute

Hazarey²,

Ahmed³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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show abstract

“…CSCs are highly tumorigenic with a greater capacity for migration, invasion, and proliferation compared to the other cancer cells (Chen, 2009 andOkamoto et al, 2009) and are believed to be largely responsible for the biological characteristics of cancer namely, rapid growth, invasion, metastasis and even recurrence after conventional therapy due to their increased resistance against radio and chemo-therapeutic modalities (Oshimori et al, 2015).…”

Section: Issn: 2320-5407mentioning

confidence: 99%

Identification of Cancer Stem Cells in Oral Squamous Cell Carcinoma Using Cripto-1.

Din¹,

Farag²,

Hassabou³

2018

IJAR

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“…The efflux capacity of the SP is attributed to increased expressed of ATP-binding cassette (ABC) transport proteins ABCB1, ABCC1, and ABCG2 [76,[78][79][80][81]. These ABC transporters are able to efflux a wide array of chemotherapeutic drugs (e.g.…”

Section: Chemoresistance Of Cancer Stem Cells By Enhanced Drug Effluxmentioning

confidence: 99%

Chemoresistance in Cancer Stem Cells and Strategies to Overcome Resistance

Thomas¹,

Coyle²,

Sultan³

et al. 2014

Chemotherapy

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In cancers, there exists a subpopulation of cells which are referred to as cancer stem cells (CSCs) or tumor initiating cells that have enhanced tumor-initiating capacity and metastatic potential, and drive tumor progression. Since the initial identification of acute myeloid leukemia CSCs in 1997, CSCs have been found in many types of cancer and have intrinsic resistance to the current chemotherapeutic strategies. With increased levels of detoxifying enzymes, enhanced DNA repair abilities, impressive efflux capacity, and a slower cell-cycle; CSCs present a formidable obstacle against effective chemotherapy. Several methods of specifically targeting CSCs have been developed in recent years, and these compounds have potential as adjuvant therapies. The following is a review of the mechanisms responsible for chemoresistance in CSCs, with an emphasis on potential strategies to overcome this resistance.

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Expansion and characterization of cancer stem-like cells in squamous cell carcinoma of the head and neck

Cited by 148 publications

References 30 publications

Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: A Review

Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: A Review

Identification of Cancer Stem Cells in Oral Squamous Cell Carcinoma Using Cripto-1.

Chemoresistance in Cancer Stem Cells and Strategies to Overcome Resistance

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