Abstract:O-Acetyl-ADP-ribose (OAADPR) is a signaling molecule identified from the conserved sirtuin reaction in Saccharomyces cerevisiae, involved in the important cellular functions of gene silencing, redox regulation, and aging. Here, we performed biochemical and structural characterization of the yeast Poa1p macro domain in detail, uncovering an unusual deacetylase activity favoring 3″-and 1″-isomers of O-acetyl-ADP-ribose. The unique active-site residues of Poa1p contributing to the distinct substrate specificity t… Show more
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