Expanding the spectrum of Epstein-Barr virus and human herpesvirus-8 co-infection associated large B-cell lymphomas with plasmablastic differentiation in HIV-positive patients: Report of two unusual cases and review of the literature

Twagirimana, Séraphin; Doucet, Stéphane; Meunier, Caroline; Maietta, Antonio

doi:10.1016/j.hpr.2022.300657

Cited by 2 publications

(4 citation statements)

References 19 publications

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“…As noted above, although most cases of ECPEL are EBV-positive, EBV negativity is not excluded in the WHO-4R. Although the WHO-4R and ICC would regard cases with both EBV and HHV8 expression as ECPEL, there are rare reports of EBER-positive HHV8-positive lymphoid neoplasia described as DLBCL or GLPD with atypical clinical or histologic/immunophenotypic features, where some may question expanding the immunophenotypic spectrum of HHV8+DLBCL (preliminary WHO-5 online beta version notes that some HHV8+ DLBCL may be dual positive) [ 16 , 17 ]. In such atypical cases, a complete study is necessary, including the mutational status of the IGHV gene.…”

Section: Extracavitary Primary Effusion Lymphoma (Ecpel)mentioning

confidence: 99%

“…The clinical setting can be helpful in differentiating GLPD from ECPEL, as GLPD typically affects elderly HIV-negative patients and ECPEL severely immunocompromised HIV-positive patients (although HIV status is not exclusive to either entity) [ 10 , 16 ]. The cytomorphology and immunophenotype of GLPD overlap with ECPEL, with plasmablasts that are HHV8, EBER, and MUM1 positive and lack B-cell markers such as CD20, CD79a, and PAX5.…”

Section: Extracavitary Primary Effusion Lymphoma (Ecpel)mentioning

confidence: 99%

“…These last three cases highlighted the challenges in specific diagnosis and the spectrum of findings that can be seen in HHV8-positive lymphoid proliferations/neoplasms (Table 2 ) [ 1 , 2 , 16 – 18 , 23 , 25 ].…”

Section: Extracavitary Primary Effusion Lymphoma (Ecpel)mentioning

confidence: 99%

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Cavity-based lymphomas: challenges and novel concepts. A report of the 2022 EA4HP/SH lymphoma workshop

Napoli

Soma

Quintanilla-Martı́nez

et al. 2023

Virchows Arch

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The 2022 European Association for Haematopathology/Society for Hematopathology lymphoma workshop session on cavity-based lymphomas included sixty-eight cases in seven sections. The disease entities discussed include primary effusion lymphomas (PEL), extracavitary primary effusion lymphomas and confounding entities (ECPEL), HHV8-negative B-lineage lymphomas-effusion based (EBV-negative, EBV-positive, and plasmablastic types), diffuse large B-cell lymphoma associated with chronic inflammation, fibrin-associated diffuse large B-cell lymphoma (FA-DLBCL), breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), and other lymphomas presenting as an effusion. All entities above are discussed; however, three are delved into greater detail given the challenges with classification: ECPEL, HHV8-negative effusion-based lymphomas, and FA-DLBCL. Cases exemplifying the diagnostic difficulty in differentiating ECPEL from HHV8-positive diffuse large B-cell lymphoma and germinotropic lymphoproliferative disorder were discussed. The more recently recognized effusion-based HHV8-negative large B-cell lymphoma is explored, with several cases submitted raising the question if this subset should be carved out as a specific entity, and if so, what should be the refining diagnostic criteria. Case submissions to the FA-DLBCL section yielded one of the largest case series to date, including classic cases, cases furthering the discussion on disease sites and prognosis, as well as novel concepts to be considered in this entity. The 2022 EA4HP/SH workshop cases allowed for further confirmation of the characteristics of some of the more historically accepted cavity-based lymphomas, as well as further inquiry and debate on relatively new or evolving entities.

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Section: Extracavitary Primary Effusion Lymphoma (Ecpel)mentioning

confidence: 99%

Section: Extracavitary Primary Effusion Lymphoma (Ecpel)mentioning

confidence: 99%

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Cavity-based lymphomas: challenges and novel concepts. A report of the 2022 EA4HP/SH lymphoma workshop

Napoli

Soma

Quintanilla-Martı́nez

et al. 2023

Virchows Arch

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“…In very rare circumstances of immunodeficiency, e.g., the acquired immune deficiency syndrome (AIDS), they may act synergistically as in the case of EBV-positive HHV8-associated large B cell lymphoma with plasmablastic differentiation [ 50 ], recently encountered during our diagnostic practice on the bone marrow biopsy from a 50-year-old female lymphopenic COVID-19 patient, pancreas and kidney transplant recipient for about 20 years due to type 1 diabetes mellitus, with a rapidly lethal course ( Figure 1 ).…”

mentioning

confidence: 99%

SARS-CoV-2 Induced Herpes Virus Reactivations and Related Implications in Oncohematology: When Lymphocytopenia Sets in and Immunosurveillance Drops Out

Roncati,

Sweidan,

Tchawa

et al. 2023

Microorganisms

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Expanding the spectrum of Epstein-Barr virus and human herpesvirus-8 co-infection associated large B-cell lymphomas with plasmablastic differentiation in HIV-positive patients: Report of two unusual cases and review of the literature

Cited by 2 publications

References 19 publications

Cavity-based lymphomas: challenges and novel concepts. A report of the 2022 EA4HP/SH lymphoma workshop

Cavity-based lymphomas: challenges and novel concepts. A report of the 2022 EA4HP/SH lymphoma workshop

SARS-CoV-2 Induced Herpes Virus Reactivations and Related Implications in Oncohematology: When Lymphocytopenia Sets in and Immunosurveillance Drops Out

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