Expanding the scope of ‘Click’ derived 1,2,3-triazole ligands: New palladium and platinum complexes

Synthesis of platinum complexes with 2-(5-perfluoroalkyl-1,2,4-oxadiazol-3yl)-pyridine and 2-(3-perfluoroalkyl-1-methyl-1,2,4-triazole-5yl)-pyridine ligands and their in vitro antitumor activity

“…The coordination of Pt(II) ion to the 2-(3-perfluoroalkyl-1-methyl-1,2,4-triazole-5yl)-pyridine ligands for 4a and 5a complexes, occurs via N2 atoms of two 1,2,4-triazole moieties as already observed in the literature for azole-bridged dinuclear platinum(II) complexes [24]. On the contrary, in the case of 4b, only one molecule of 1,2,4-triazolyl-pyridine is coordinated to Pt(II) ion via N4 atom of triazole moiety and N1 atom of pyridine respectively, where the ligand is bidentate as reported in literature with Pt(II) and Pd(II) ions [8]. Cytotoxicity in vitro of the synthesized cisplatin analogs was evaluated by MTT test on three tumor human cell lines: HepG2, MCF-7 and HTC116.…”

“…In the past years, successful approaches have been employed to solve these drawbacks, combining platinum-based drugs with some other active pharmacophore so that a synergic action can be obtained [6]. Oxadiazole and triazole have been recently used for complexation of metal such as copper, nickel [7], palladium [8] and platinum [9]; 1,2,4-oxadiazoles have been widely studied for their chemistry [10][11][12], these heterocycles have gained attention for their pharmaceutical properties, and additionally, the presence of the fluorinated moiety opens the way to new fluorine-induced activity with respect to corresponding non-fluorinated systems [13][14][15][16] and application in materials [17][18][19][20][21]. In particular, a series of Pt(II) complexes with 1,2,4-oxadiazole derivatives as ligands have shown cytotoxic activity towards human ovarian cancer, and also in colon and testicular cancer cell lines.…”

Structure–Property Relationships in Click‐Derived Donor–Triazole–Acceptor Materials

“…[14] These materials are based on click-functionalized ene-yne compounds with an 1,2,3-triazole linker as an essentialb uilding block. The crystal structures of BTazB, [25] BTaz-Pyr, [26] DMATazB, [27] DMATazPyr, [28] and BTazDMA [27] are known from the work of other groups. Unfortunately,n ou sable crystalsc ould be grown for the benzene-linked series.…”

Palladium-containing polymers via a combination of RAFT and triazole chemistry

“…2 and 3). 32,33 In the solid state, 1 adopts a conformation typical for (1H-1,2,3-triazol-4-yl)pyridines (Fig. 1.…”

“…3). 32,33 The N-Pd-N bite angles of the ligand in 2 are N1-Pd1-N2 80.2(2) and N5-Pd2-N6 80.8 (2) . 32,33 As expected for d 8 valence electron configurated Pd(II), a square-planar coordination environment is observed.…”