Expanding the Knowledge on the Skillful Yeast Cyberlindnera jadinii

Abstract

Cyberlindnera jadinii is widely used as a source of single-cell protein and is known for its ability to synthesize a great variety of valuable compounds for the food and pharmaceutical industries. Its capacity to produce compounds such as food additives, supplements, and organic acids, among other fine chemicals, has turned it into an attractive microorganism in the biotechnology field. In this review, we performed a robust phylogenetic analysis using the core proteome of C. jadinii and other fungal species, from Asco- to Basidiomycota, to elucidate the evolutionary roots of this species. In addition, we report the evolution of this species nomenclature over-time and the existence of a teleomorph (C. jadinii) and anamorph state (Candida utilis) and summarize the current nomenclature of most common strains. Finally, we highlight relevant traits of its physiology, the solute membrane transporters so far characterized, as well as the molecular tools currently available for its genomic manipulation. The emerging applications of this yeast reinforce its potential in the white biotechnology sector. Nonetheless, it is necessary to expand the knowledge on its metabolism, regulatory networks, and transport mechanisms, as well as to develop more robust genetic manipulation systems and synthetic biology tools to promote the full exploitation of C. jadinii.

Yeast community composition impacts on tequila industry waste treatment for pollution control and waste-to-product synthesis

“…Overall, C. utilis and K. marxianus demonstrated the best potential to grow using TV as substrate while simultaneously removing pollutants (COD, TN and TP) in order to synthesize protein-rich biomass as previously reported by (Díaz-Vázquez et al, 2022). C. utilis has been reported to have robust fermentation characteristics and a high tolerance to environmental changes and can produce biomass rich in Frontiers in Chemical Engineering frontiersin.org protein, vitamins, and amino acid diversity, which are ideal characteristics for an animal feed protein supplement (Buerth et al, 2016;Sousa-Silva et al, 2021). Furthermore, C. utilis has the capacity to assimilate carbon (organic acids, alcohol, propionaldehyde, acetaldehyde) and nitrogen (nitrate, nitrite, ammonium hydroxide, amino acids) sources (Buerth et al, 2016) producing high protein yields (dos Santos et al, 2019).…”

Development of CRISPR/Cas9-Based Genome Editing Tools for Polyploid Yeast Cyberlindnera jadinii and Its Application in Engineering Heterologous Steroid-Producing Strains

“…Cyberlindnera jadinii is a member of the yeast family Phaffomycetaceae, and its anamorph state is recognized as Candida utilis. 1 This strain has been certified as GRAS (Generally Recognized As Safe) by the U.S. Food and Drug Administration (FDA) 2 and has been utilized in the food and feed industry for nearly a century. C. jadinii displays the characteristics of a "Crabtree-negative" yeast, which tends to direct sugar metabolism to respiratory metabolism and biomass accumulation under aerobic conditions.…”

Dietary supplementation with Cyberlindnera jadinii improved growth performance, serum biochemical Indices, antioxidant status, and intestinal health in growing raccoon dogs (Nyctereutes procyonoides)

“…The yeast Cyberlindnera jadinii is a close relative of Candida utilis , which is currently used in the food and feed industries ( Rupp et al, 2015 ). Cyberlindnera jadinii can produce valuable bioproducts that are an attractive source of biomass enriched in protein and vitamins ( Sousa-Silva et al, 2021 ). Partially replacing conventional protein sources with inactivated Cyberlindnera jadinii yeast in for the diet of young pigs is possible without compromising energy and protein metabolism ( Cruz et al, 2020 ).…”