Expanding the genetic toolbox for the obligate human pathogen Streptococcus pyogenes
Nina Lautenschläger,
Katja Schmidt,
Carolin Schiffer
et al.
Abstract:Genetic tools form the basis for the study of molecular mechanisms. Despite many recent advances in the field of genetic engineering in bacteria, genetic toolsets remain scarce for non-model organisms, such as the obligatory human pathogen Streptococcus pyogenes. To overcome this limitation and enable the straightforward investigation of gene functions in S. pyogenes, we have developed a comprehensive genetic toolset. By adapting and combining different tools previously applied in other Gram-positive bacteria,… Show more
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