Abstract:Alkannin, shikonin (A/S) and their derivatives are naturally occurring hydroxynaphthoquinones biosynthesized in some species of the Boraginaceae family. These natural compounds have been extensively investigated for their biological properties over the last 40 years, demonstrating a plethora of activities, such as wound healing, regenerative, anti-inflammatory, antitumor, antimicrobial and antioxidant. This study aims to extend the current knowledge by investigating the effects of various A/S compounds on two … Show more
“…148,[193][194][195][196] Another example is naphtazarin treatment, which in concentrations of up to 500 mM causes a lifespan extending effect on solid media, 197 while in liquid culture it exerts a potent nematotoxic effect already at 79 mM. 198 This controversial effect may be due to a greater uptake of compounds in liquid culture as it is reported for resveratrol and uoxuridine. 161 "Sola dosis facit venenum"the dose makes the poison.…”
Section: Nps In C Elegans-based Drug Screeningmentioning
This review covers the role of the nematode Caenorhabditis elegans as a whole organism model to study natural products for healthy aging. Literature between 2012 and 2023 was comprehensively analysed and is presented in a concise way.
“…148,[193][194][195][196] Another example is naphtazarin treatment, which in concentrations of up to 500 mM causes a lifespan extending effect on solid media, 197 while in liquid culture it exerts a potent nematotoxic effect already at 79 mM. 198 This controversial effect may be due to a greater uptake of compounds in liquid culture as it is reported for resveratrol and uoxuridine. 161 "Sola dosis facit venenum"the dose makes the poison.…”
Section: Nps In C Elegans-based Drug Screeningmentioning
This review covers the role of the nematode Caenorhabditis elegans as a whole organism model to study natural products for healthy aging. Literature between 2012 and 2023 was comprehensively analysed and is presented in a concise way.
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