Expanding the anti-inflammatory potential of Moringa oleifera: topical effect of seed oil on skin inflammation and hyperproliferation

Cretella, Ananda Beatriz Munhoz; Soley, Bruna da Silva; Pawloski, Priscila Lúcia; Ruziska, Rebecca Marquini; Scharf, Dilamara Riva; Ascari, Jociani; Cabrini, Daniela Almeida; Otuki, Michel Fleith

doi:10.1016/j.jep.2020.112708

Cited by 21 publications

(6 citation statements)

References 30 publications

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“…The dominant The dominant compound in MOSEIL is oleic acid (37.546%) which is a fatty acid group. Oleic acid is the main component of Moringa seed oil with a percentage of approximately 72.27% (37). The benefits of oleic acid are to prevent and treat various types of diseases such as cardiovascular or autoimmune, metabolic disorders and as an anticancer and are used for obesity diets (38).…”

Section: Phytochemical Composition Of Molp and Moseil By Gc-ms Analysismentioning

confidence: 99%

Phytochemical Profiling and Pharmaceutical Properties of Moringa oleifera Leaves Powder and Seed Oil Against Hepatocellular Carcinoma

Susanto,

Wonorahardjo,

Putra

et al. 2023

Mal. J. Fund. Appl. Sci.

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Hepatocellular carcinoma (HCC) is one of the deadliest types of cancer with a mortality rate of 8.9% of the total cancer deaths in Indonesia. This cancer can be caused by exposure to hepatitis B and C viruses, NAFLD, autoimmune, diabetes to sporadic genetic diseases. The development of chronic HCC is generally preceded by the occurrence of severe liver fibrosis and cirrhosis. One of the genes that play a role in fibrosis in the incidence of HCC is TGF-β1. As a pro-fibrotic cytokine, the presence of high levels of TGF-β1 may be due to oxidative stress activity early in cancer development. One of the natural ingredients with lots of phytochemical content in the form of antioxidants that can reduce this activity is Moringa plant (Moringa oleifera). In this study we used a computational approach using molecular docking on the results of the GC-MS and LC-HRMS tests on Moringa oleifera Seed Oil (MOSEIL) and Moringa oleifera Leaves Powder (MOLP) which are oil and flour products made from moringa. The results of the identification of phytochemical compounds through the GC-MS test showed that the dominant compound in MOSEIL was oleic acid (37.546%) and in MOLP was ester (8.802%) when using n-hexane as solvent. The percentage yield of the dominant compound from the LC-HRMS test in MOSEIL was nitro compound (72.55%) and at MOLP was alcohol (45.87%). These compounds are known to have effects as hepatoprotective agents through antioxidant, anti-inflammatory, and anti-fibrotic activities that can reduce hepatic oxidative stress as an early trigger of cancer development. Through molecular docking, MOSEIL and MOLP showed a lower level of binding affinity when compared to TGF-β1 control drugs such as metformin. This data implies MOSEIL and MOLP have a strong interaction to TGF-β1 than the control drug. The therapeutic potential of the hepatoprotective properties of MOSEIL and MOLP makes them one of the most-promising therapeutic agents in the initial step of renewable cancer treatment therapy.

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Section: Phytochemical Composition Of Molp and Moseil By Gc-ms Analysismentioning

confidence: 99%

Phytochemical Profiling and Pharmaceutical Properties of Moringa oleifera Leaves Powder and Seed Oil Against Hepatocellular Carcinoma

Susanto,

Wonorahardjo,

Putra

et al. 2023

Mal. J. Fund. Appl. Sci.

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“…Anti-inflammatory properties of M. oleifera oil were studied in vivo by Cretella et al [ 138 ] and Jaja-Chimedza et al [ 31 ]. Topically administered seed oil decreased ear inflammation and edema induced in rats by tetradecanoylphorbol-13-acetate (TPA) (by 69.2 ± 8.8%) or phenol (by 61.2 ± 10.9%), though the anti-inflammatory effect was due to interaction with glucocorticoid receptors, which raises concerns about the potential side effects [ 138 ].…”

Section: Chemical Content Of Seeds Eaten With Whole Fruit and Biologi...mentioning

confidence: 99%

Selected Seeds as Sources of Bioactive Compounds with Diverse Biological Activities

Sławińska

Olas

2022

Nutrients

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Seeds contain a variety of phytochemicals that exhibit a wide range of biological activities. Plant-derived compounds are often investigated for their antioxidant, anti-inflammatory, immunomodulatory, hypoglycemic, anti-hypercholesterolemic, anti-hypertensive, anti-platelet, anti-apoptotic, anti-nociceptive, antibacterial, antiviral, anticancer, hepatoprotective, or neuroprotective properties. In this review, we have described the chemical content and biological activity of seeds from eight selected plant species—blackberry (Rubus fruticosus L.), black raspberry (Rubus coreanus Miq.), grape (Vitis vinifera L.), Moringa oleifera Lam., sea buckthorn (Hippophae rhamnoides L.), Gac (Momordica cochinchinensis Sprenger), hemp (Cannabis sativa L.), and sacha inchi (Plukenetia volubilis L). This review is based on studies identified in electronic databases, including PubMed, ScienceDirect, and SCOPUS. Numerous preclinical, and some clinical studies have found that extracts, fractions, oil, flour, proteins, polysaccharides, or purified chemical compounds isolated from the seeds of these plants display promising, health-promoting effects, and could be utilized in drug development, or to make nutraceuticals and functional foods. Despite that, many of these properties have been studied only in vitro, and it’s unsure if their effects would be relevant in vivo as well, so there is a need for more animal studies and clinical trials that would help determine if they could be applied in disease prevention or treatment.

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“…19 Moringa oleifera (MO) has various biological activities including anti-inflammatory, antioxidant and neuroprotective properties. 20,21 These pharmacological effects are associated with ingredients such as phenolic acids, flavonoids (quercetin, iso quercetin, isothiocyanates and glycosides, apigenin, myricetin, rhamnetin, kaempferol), alkaloids, phytosterols, glucosinolates, glycosides, minerals, organic acids, and vitamins. 22,23 MO supplemented diet significantly ameliorated oxidoinflammatory stress, restored cholinergic transmission via acetylcholinesterase inhibition and maintains neuronal integrity in the brain in scopolamine-induced spatial memory deficit in mice.…”

Section: Introductionmentioning

confidence: 99%

The Oil Formulation Derived from Moringa Oleifera Seeds Ameliorates Behavioral Abnormalities in Water-immersion Restraint Stress Mouse Model

Purwoningsih¹,

Arozal²,

Lee³

et al. 2022

JEP

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Purpose Repeated stress events are well known to be associated with the onset of behavioral abnormalities including depression, anxiety and memory impairment. In spite of the traditional uses of Moringa oleifera (MO), no experimental evidence for its use against chronic stress exists. Here, we investigated whether seed oil from MO (MOO) could improve behavior abnormalities of chronic stress mice induced by water-immersion restraint stress (WIRS) and the underlying mechanism. Methods BALB/C male mice at 12 weeks of age were exposed to chronic WIRS for two weeks and divided in to four groups: normal group, WIRS group, WIRS+MOO1 group (treated with MOO at the dose of 1 mL/kg BW), and WIRS+MOO2 group (treated with MOO 2 mL/kg BW). The MOO treatment was given orally for 23 days. On day 24, we checked the behavior parameters, the plasma level of cortisol, acetylcholinesterase (AChE) activity in hippocampus, mRNA expression level of brain-derived neurotrophic factor ( BDNF ) and oxidative stress parameters in brain tissues. In addition, we also checked the histopathological features of the gastric mucosa wall. Results Administration of MOO ameliorated anxiety-like, depression-like and memory impairment phenotypes in the WIRS mouse model although the plasma cortisol concentrations were comparable among the groups. Of note, MOO both in two doses could suppress the AChE activity in hippocampus tissue and ameliorated the MDA level in prefrontal cortex tissue in mice exposed to WIRS. Although only WIRS+MOO2 group could increase the mRNA expression of BDNF , the histopathological gastric mucosa wall features were improved in all MOO groups. Conclusion Taken together, these finding suggested that MOO may have a neuroprotective effect in the mouse model of WIRS as evidenced by improving the abnormal behaviors through enhancing mRNA expression level of BDNF , inhibited AChE activity, and prevented the increase of MDA level in the brain.

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Expanding the anti-inflammatory potential of Moringa oleifera: topical effect of seed oil on skin inflammation and hyperproliferation

Cited by 21 publications

References 30 publications

Phytochemical Profiling and Pharmaceutical Properties of Moringa oleifera Leaves Powder and Seed Oil Against Hepatocellular Carcinoma

Phytochemical Profiling and Pharmaceutical Properties of Moringa oleifera Leaves Powder and Seed Oil Against Hepatocellular Carcinoma

Selected Seeds as Sources of Bioactive Compounds with Diverse Biological Activities

The Oil Formulation Derived from Moringa Oleifera Seeds Ameliorates Behavioral Abnormalities in Water-immersion Restraint Stress Mouse Model

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