2013
DOI: 10.4161/cc.24332
|View full text |Cite
|
Sign up to set email alerts
|

Expanding SUMO and ubiquitin-mediated signaling through hybrid SUMO-ubiquitin chains and their receptors

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
22
0

Year Published

2014
2014
2020
2020

Publication Types

Select...
5
3
1

Relationship

0
9

Authors

Journals

citations
Cited by 29 publications
(22 citation statements)
references
References 8 publications
0
22
0
Order By: Relevance
“…4952 The SUMO2-3 isoforms perform poly-SUMOylation PTMs and can modulate protein degradation. 53,54 Recent studies suggest that the SUMO2-3 isoforms can also target proteins for poly-ubiquitination and subsequent degradation via the proteasome. 54,55 SUMO4 differs from the other isoforms in that it has proline rather than glutamine at residue 90 and is not processed and conjugated at baseline.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…4952 The SUMO2-3 isoforms perform poly-SUMOylation PTMs and can modulate protein degradation. 53,54 Recent studies suggest that the SUMO2-3 isoforms can also target proteins for poly-ubiquitination and subsequent degradation via the proteasome. 54,55 SUMO4 differs from the other isoforms in that it has proline rather than glutamine at residue 90 and is not processed and conjugated at baseline.…”
Section: Discussionmentioning
confidence: 99%
“…53,54 Recent studies suggest that the SUMO2-3 isoforms can also target proteins for poly-ubiquitination and subsequent degradation via the proteasome. 54,55 SUMO4 differs from the other isoforms in that it has proline rather than glutamine at residue 90 and is not processed and conjugated at baseline. It can, however, be hydrolyzed under certain stress conditions.…”
Section: Discussionmentioning
confidence: 99%
“…The establishment of hybrid chains at DNA damage sites, through the activity of the SUMO-targeted ubiquitin ligase RNF4, recruits RAP80 and the BRCA1-A complex to DNA lesions (41). In addition, the proteasomal subunit S5a/RPN10, which has protease activity, bears UIM and SIM motifs and it is intriguing to think that this protein could be responsible for the docking of hybrid SUMO-ubiquitin chains at the proteasome (42). …”
Section: Sumo Is Involved In Proteostasis Via Crosstalk With Ubiquitinmentioning
confidence: 99%
“…In general, the SIMs contain a hydrophobic core (V/I-X-V/I-V/I or V/I-V/I-X-V/I/L) flanked by acidic residues either upstream or downstream (14)(15)(16)(17). In addition to being structurally related, ubiquitin and SUMO modifications of substrates occur preferentially on lysine residues, and ubiquitin can be hybridized with the SUMO moiety by anchoring to the lysine on poly-SUMO (18,19). Cross talk between the two PTMs may be involved in genome stability and cell growth, which are associated with pathogen resistance and cancer treatment (20).…”
mentioning
confidence: 99%