Expanding arsenal against diabetic wounds using nanomedicines and nanomaterials: Success so far and bottlenecks

Awasthi, Ankit; Vishwas, Sukriti; Gulati, Monica; Corrie, Leander; Kaur, Jaskiran; Khursheed, Rubiya; Alam, Aftab; Alkhayl, Faris F. Aba; Khan, Farhan R.; Nagarethinam, Sivagurunathan; Kumar, Rajan; Arya, K.R.; Kumar, Bimlesh; Chellappan, Dinesh Kumar; Gupta, Gaurav; Dua, Kamal; Singh, Sachin Kumar

doi:10.1016/j.jddst.2022.103534

Cited by 6 publications

(7 citation statements)

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“…Overall, these contributing factors often result in amputation and even the death of the DFU patient. The global prevalence of amputation due to DFU in 2022 is reported to be 10-15% [3].…”

Section: Introductionmentioning

confidence: 99%

“…Dressings which are currently available to manage DFU have some limitations, such as the inability to absorb the exudate and high cost. Antibiotics can decrease microbial load but not heal the wound [1][2][3]. These treatment strategies are expensive and underline the need for a multi-disciplinary, cost-effective approach to control hyperglycemia with the potential to target different stages of DFU.…”

Section: Introductionmentioning

confidence: 99%

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Gut Dysbiosis and Diabetic Foot Ulcer: Role of Probiotics

et al. 2022

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Diabetic foot ulcer (DFU) is a multifactorial disease and one of the complications of diabetes. The global burden of DFU in the health sector is increasing at a tremendous rate due to its cost management related to hospitalization, medical costs and foot amputation. Hence, to manage DFU/DWs, various attempts have been made, including treating wounds systematically/topically using synthetic drugs, herbal drugs, or tissue engineering based surgical dressings. However, less attention has been paid to the intrinsic factors that are also the leading cause of diabetes mellitus (DM) and its complications. One such factor is gut dysbiosis, which is one of the major causes of enhancing the counts of Gram-negative bacteria. These bacteria produce lipopolysaccharides, which are a major contributing factor toward insulin resistance and inflammation due to the generation of oxidative stress and immunopathy. These all lead to DM and DFU. Probiotics are the commercial form of beneficial gut microbes that are taken as nutraceuticals by people of all ages to improve gut immunity and prevent gut dysbiosis. However, the role of probiotics has been less explored in the management of DFU. Hence, the therapeutic potential of probiotics in managing DFU is fully described in the current review. This report covers the linkage between gut dysbiosis and DFU, sources of probiotics, the mechanisms of probiotics in DW healing, and the impact of probiotic supplementation in treating DFU. In addition, techniques for the stabilization of probiotics, market status, and patents related to probiotics have been also covered. The relevant data were gathered from PubMed, Scopus, Taylor and Francis, Science Direct, and Google Scholar. Our systematic review discusses the utilization of probiotic supplementation as a nutraceutical for the management of DFU.

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“…Overall, these contributing factors often result in amputation and even the death of the DFU patient. The global prevalence of amputation due to DFU in 2022 is reported to be 10-15% [3].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gut Dysbiosis and Diabetic Foot Ulcer: Role of Probiotics

et al. 2022

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“…Although delivery system great progress has been made in the eld of novel drug delivery such as liposomes, niosomes, transfersomes, exosomes, nano-hydrogels and SLNs, there are still a number of limitations. [98][99][100] Their clinical translation is hindered by their storage instability, toxicity, poor drug loading and yield, poor site specicity and expensive manufacturing procedures and so on. Therefore, researchers need to identify better strategies to ensure that these functional nucleic acids are efficiently delivered to the appropriate cells.…”

Section: Discussionmentioning

confidence: 99%

Functional nucleic acids for the treatment of diabetic complications

Wen,

Wei,

Gao

2023

Nanoscale Adv.

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“…Besides these, other polymers used to fabricate scaffolds are pullulan, starch, dextran, and cellulose. Among these polysaccharides [70], chitosan [71], alginate [72,73], konjac gum [74,75], cellulose [76][77][78], Ganoderma lucidum [74,75], and β-glucan [79][80][81] based scaffolds have been utilized for DW. These have been discussed in the subsequent sections.…”

Section: Natural Polymersmentioning

confidence: 99%

“…The incorporation of SV-MSC NLCs into the scaffold delayed the initial burst release of SV on 24 h as compared to SV NLCs and maintained a more controlled drug release profile for 24 h by increasing the plateau level. Moreover, topical application of SV NLC-based scaffolds exhibited 3.1-folds, 1.19-folds, 2.5-folds, 1.02-folds, and 1.97-folds decrease in wound area as compared to diabetic control, placebo NLC scaffolds, free SV scaffolds, SV NLC scaffolds, and MSC scaffold-treated groups, respectively [ 71 ].…”

Section: Materials Used In Scaffold Fabricationmentioning

confidence: 99%

Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds

Awasthi

Gulati

Kumar

et al. 2022

BioMed Research International

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Diabetic wound (DW) is a secondary application of uncontrolled diabetes and affects about 42.2% of diabetics. If the disease is left untreated/uncontrolled, then it may further lead to amputation of organs. In recent years, huge research has been done in the area of wound dressing to have a better maintenance of DW. These include gauze, films, foams or, hydrocolloid-based dressings as well as polysaccharide- and polymer-based dressings. In recent years, scaffolds have played major role as biomaterial for wound dressing due to its tissue regeneration properties as well as fluid absorption capacity. These are three-dimensional polymeric structures formed from polymers that help in tissue rejuvenation. These offer a large surface area to volume ratio to allow cell adhesion and exudate absorbing capacity and antibacterial properties. They also offer a better retention as well as sustained release of drugs that are directly impregnated to the scaffolds or the ones that are loaded in nanocarriers that are impregnated onto scaffolds. The present review comprehensively describes the pathogenesis of DW, various dressings that are used so far for DW, the limitation of currently used wound dressings, role of scaffolds in topical delivery of drugs, materials used for scaffold fabrication, and application of various polymer-based scaffolds for treating DW.

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Expanding arsenal against diabetic wounds using nanomedicines and nanomaterials: Success so far and bottlenecks

Cited by 6 publications

References 301 publications

Gut Dysbiosis and Diabetic Foot Ulcer: Role of Probiotics

Gut Dysbiosis and Diabetic Foot Ulcer: Role of Probiotics

Functional nucleic acids for the treatment of diabetic complications

Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds

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