Expanding applications of deep brain stimulation: a potential therapeutic role in obesity and addiction management

Halpern, Casey H.; Torres, Napoléon; Hurtig, Howard I.; Wolf, John A.; Stephen, James H.; Oh, Michael; Williams, Noel N.; Dichter, Marc A.; Jaggi, Jurg L.; Caplan, Arthur L.; Kampman, Kyle M.; Wadden, Thomas A.; Whiting, Donald; Baltuch, Gordon H.

doi:10.1007/s00701-011-1166-3

Cited by 49 publications

(40 citation statements)

References 152 publications

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“…Deep brain stimulation (DBS) is currently being examined for the treatment of various psychiatric disorders (Goodman and Alterman, 2012;Holtzheimer and Mayberg, 2011;Krack et al, 2010;Ward et al, 2010), including addiction (Halpern et al, 2011;Luigjes et al, 2012). Several reports have established the potential of DBS in the region of the nucleus accumbens (NAcc) in human subjects for the treatment of heroin (Zhou et al, 2011), alcohol (Kuhn et al, 2007(Kuhn et al, , 2011Muller et al, 2009), and nicotine (Kuhn et al, 2009;Mantione et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors

Pushparaj

Hamani

et al. 2012

Neuropsychopharmacol

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Pharmacological inactivation of the granular insular cortex is able to block nicotine-taking and -seeking behaviors in rats. In this study, we explored the potential of modulating activity in the insular region using electrical stimulation. Animals were trained to self-administer nicotine (0.03 mg/kg per infusion) under a fixed ratio-5 (FR-5) schedule of reinforcement followed by a progressive ratio (PR) schedule. Evaluation of the effect of stimulation in the insular region was performed on nicotine self-administration under FR-5 and PR schedules, as well on reinstatement of nicotine-seeking behavior induced by nicotine-associated cues or nicotine-priming injections. The effect of stimulation was also examined in brain slices containing insular neurons. Stimulation significantly attenuated nicotine-taking, under both schedules of reinforcement, as well as nicotine-seeking behavior induced by cues and priming. These effects appear to be specific to nicotine-associated behaviors, as stimulation did not have any effect on food-taking behavior. They appear to be anatomically specific, as stimulation surrounding the insular region had no effect on behavior. Stimulation of brain slices containing the insular region was found to inactivate insular neurons. Our results suggest that deep brain stimulation to modulate insular activity should be further explored.

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Section: Introductionmentioning

confidence: 99%

Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors

Pushparaj

Hamani

et al. 2012

Neuropsychopharmacol

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“…We were then able to stimulate the mPFC at the precise moment of each lever press. We also stimulated the NAc in the same behavioral situation-it has been shown that the NAc is involved in neural circuits related to food intake (Stratford and Kelley 1997;Kelley et al 2005) and other aspects of feeding behaviors such as food selection according to their palatability (Halpern et al 2011). Because the hippocampus has been related with different types of associative (classical eyeblink conditioning) and nonassociative (object recognition, spatial orientation) learning tasks (Gruart et al 2006;Rossato et al 2007;Moser et al 2008;Clarke et al 2010), for comparative purposes, we stimulated the dorsal hippocampus (pyramidal CA1 area) during the same set of ongoing behaviors.…”

mentioning

confidence: 99%

Observational learning in mice can be prevented by medial prefrontal cortex stimulation and enhanced by nucleus accumbens stimulation

Jurado-Parras¹,

Gruart²,

Delgado‐García³

2012

Learn. Mem.

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The neural structures involved in ongoing appetitive and/or observational learning behaviors remain largely unknown. Operant conditioning and observational learning were evoked and recorded in a modified Skinner box provided with an on-line video recording system. Mice improved their acquisition of a simple operant conditioning task by observational learning. Electrical stimulation of the observer's medial prefrontal cortex (mPFC) at a key moment of the demonstration (when the demonstrator presses a lever in order to obtain a reward) cancels out the benefits of observation. In contrast, electrical stimulation of the observer's nucleus accumbens (NAc) enhances observational learning. Ongoing cognitive processes in the demonstrator could also be driven by electrical stimulation of these two structures, preventing the proper execution of the ongoing instrumental task (mPFC) or stopping pellet intake (NAc). Long-term potentiation (LTP) evoked in these two cortical structures did not prevent the acquisition or retrieval process-namely, mPFC and/or NAc stimulation only prevented, or modified, the ongoing behavioral process. The dorsal hippocampus was not involved in either of these two behavioral processes. Thus, both ongoing observational learning and performance of an instrumental task require the active contribution of the mPFC and/or the NAc.

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“…91 Furthermore, rodent NAc-lesioning models indicate significant reductions in weight and in binge-eating and food-hoarding behaviors. 25,42 Activity in the NAc is increased in individuals who imagine eating highly palatable foods, and visual cues disproportionately stimulate the reinforcement circuits in obese and leptindeficient individuals in anticipation of these visualized rewards. 17,65,79,89 Interestingly, both HFS and low-frequency stimulation (≤ 50 Hz) effectively stimulate the NAc.…”

Section: Nucleus Accumbensmentioning

confidence: 99%

Deep brain stimulation for obesity: past, present, and future targets

Dupré¹,

Tomycz²,

Oh³

et al. 2015

FOC

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The authors review the history of deep brain stimulation (DBS) in patients for treating obesity, describe current DBS targets in the brain, and discuss potential DBS targets and nontraditional stimulation parameters that may improve the effectiveness of DBS for ameliorating obesity. Deep brain stimulation for treating obesity has been performed both in animals and in humans with intriguing preliminary results. The brain is an attractive target for addressing obesity because modulating brain activity may permit influencing both sides of the energy equation—caloric intake and energy expenditure.

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Expanding applications of deep brain stimulation: a potential therapeutic role in obesity and addiction management

Abstract: Well-designed pilot studies and clinical trials enrolling carefully selected patients with obesity or addiction should be initiated.

Cited by 49 publications

References 152 publications

Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors

Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors

Observational learning in mice can be prevented by medial prefrontal cortex stimulation and enhanced by nucleus accumbens stimulation

Deep brain stimulation for obesity: past, present, and future targets

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