Expanding access to naloxone in the United States

Doyon, Suzanne; Aks, Steven E.; Schaeffer, Scott

doi:10.3109/15563650.2014.968657

Cited by 37 publications

(19 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our investigation is among the first to examine frequency of repeat non‐fatal overdose events using EMS naloxone administration as a method of surveillance. Expanded access to naloxone is generally viewed as a promising policy to address opioid overdose due to the drug's effectiveness in decreasing overdose deaths , cost‐effectiveness and limited potential for adverse events . However, critics have argued recently that naloxone may enable or escalate drug use by proving a safety net and that naloxone is being administered to the same person for multiple overdose events .…”

Section: Discussionmentioning

confidence: 99%

EMS naloxone administration as non‐fatal opioid overdose surveillance: 6‐year outcomes in Marion County, Indiana

et al. 2018

View full text Add to dashboard Cite

Background and Aims Despite rising rates of opioid overdose in the United States, few studies have examined the frequency of non-fatal overdose events or mortality outcomes following resuscitation. Given the widespread use of naloxone to respond to overdose-related deaths, naloxone administration may provide a useful marker of overdose events to identify high-risk users at heightened risk of mortality. We used naloxone administration by emergency medical services as a proxy measure of non-fatal overdose to examine repeat events and mortality outcomes during a 6-year period. Methods We conducted a retrospective investigation of all cases in Marion County, Indiana between January 2011 and December 2016 where emergency medical services used naloxone to resuscitate a patient. Cases were linked to vital records to assess mortality and cause of death during the same time-period. We used Cox regression survival analysis to assess whether repeat non-fatal overdose events during the study period were associated with the hazard of mortality, both overall and by cause of death. Results Of 4726 patients administered naloxone, 9.4% (n = 444) died an average of 354 days [standard deviation (SD) = 412.09, range = 1-1980] following resuscitation. Decedents who died of drug-related causes (34.7%, n = 154) were younger and more likely to have had repeat non-fatal overdose events. Patients with repeat non-fatal overdose events (13.4%, n = 632) had a ×2.07 [95% confidence interval (CI) = 1.59, 2.71] higher hazard of all-cause mortality and a ×3.06 (95% CI = 2.13, 4.40) higher hazard of drug-related mortality. Conclusions Among US emergency medical service patients administered naloxone for opioid overdose, those with repeat non-fatal opioid overdose events are at a much higher risk of mortality, particularly drug-related mortality, than those without repeat events.

show abstract

Section: Discussionmentioning

confidence: 99%

EMS naloxone administration as non‐fatal opioid overdose surveillance: 6‐year outcomes in Marion County, Indiana

et al. 2018

View full text Add to dashboard Cite

show abstract

“…10 Overdose education and naloxone distribution (OEND) programs have been successful harm reduction strategies among communities of drug users, and they have reduced opioid-related overdose for over 20 years. 11 Community-based naloxone distribution has led to a decrease in opioid-overdose mortality in Chicago and Massachusetts. 12,13 There has been significant need to translate lessons learned in the community to traditional health care settings where opioid use is prevalent and opioid overdose is being managed.…”

mentioning

confidence: 99%

Implementing an overdose education and naloxone distribution program in a health system

Devries¹,

Rafie²,

Polston³

2017

Journal of the American Pharmacists Association

View full text Add to dashboard Cite

show abstract

“…With the American Association of Poison Control Centers (AAPCC) supporting widening access to naloxone, and recommending the use of US poison centers (PCs) for assistance regarding the use of naloxone, they are in a unique position to track naloxone trends and the related outcomes . Despite prior studies on several aspects of naloxone use , information on US PC‐reported naloxone use is limited .…”

Section: Introductionmentioning

confidence: 99%