Expanding Access to BRCA1/2 Genetic Counseling with Telephone Delivery: A Cluster Randomized Trial

Kinney, Anita Y.; Butler, Karin M.; Schwartz, Marc D.; Mandelblatt, Jeanne S.; Boucher, Kenneth M.; Pappas, Lisa M.; Gammon, Amanda; Kohlmann, Wendy; Edwards, Sandra L.; Stroup, Antoinette M.; Buys, Saundra S.; Flores, Kristina G.; Campo, Rebecca

doi:10.1093/jnci/dju328

Cited by 111 publications

(142 citation statements)

References 52 publications

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“…No difference in satisfaction32 was reported in one. Two were non-inferiority trials and found telephone counselling was non-inferior to TC,11 12 though lower testing uptake was reported in one 11. Telegenetics has been compared with TC in an RCT and reported to costless with no difference in satisfaction, though it was associated with 10% lower attendance 33.…”

Section: Discussionmentioning

confidence: 99%

Cluster-randomised non-inferiority trial comparing DVD-assisted and traditional genetic counselling in systematic population testing for BRCA1/2 mutations

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Cluster-randomised non-inferiority trial comparing DVD-assisted and traditional genetic counselling in systematic population testing for BRCA1/2 mutations

et al. 2016

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“…PCPs could benefit from genetics-related electronic health record tools, and those in community settings could particularly benefit from a team-based approach that includes assistance of a genetic professional trained in risk assessment and communication. Future research to evaluate technology-based approaches that extend the reach of a limited genetics workforce, such as telegenetics, 76,77 telephone counseling, 78,79 and web-based case conferencing, 80 may address this need.…”

Section: Discussionmentioning

confidence: 99%

Primary care providers’ cancer genetic testing-related knowledge, attitudes, and communication behaviors: A systematic review and research agenda

et al. 2016

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BACKGROUND: Primary care providers (PCPs) can play a critical role in helping patients receive the preventive health benefits of cancer genetic risk information. Thus, the objective of this systematic review was to identify studies of US PCPs' knowledge, attitudes, and communication-related behaviors regarding genetic tests that could inform risk-stratification approaches for breast, colorectal, and prostate cancer screening in order to describe current findings and research gaps. METHODS: We conducted a systematic search of six electronic databases to identify peer-reviewed empirical articles relating to US PCPs and genetic testing for breast, colorectal, or prostate cancer published in English from 2008 to 2016. We reviewed these data and used narrative synthesis methods to integrate findings into a descriptive summary and identify research needs. RESULTS: We identified 27 relevant articles. Most focused on genetic testing for breast cancer (23/27) and colorectal cancer risk (12/27); only one study examined testing for prostate cancer risk. Most articles addressed descriptive research questions (24/27). Many studies (24/27) documented PCPs' knowledge, often concluding that providers' knowledge was incomplete. Studies commonly (11/27) examined PCPs' attitudes. Across studies, PCPs expressed some concerns about ethical, legal, and social implications of testing. Attitudes about the utility of clinical genetic testing, including for targeted cancer screening, were generally favorable; PCPs were more skeptical of direct-to-consumer testing. Relatively fewer studies (9/27) examined PCPs' communication practices regarding cancer genetic testing. DISCUSSION: This review indicates a need for investigators to move beyond descriptive research questions related to PCPs' knowledge and attitudes about cancer genetic testing. Research is needed to address important gaps regarding the development, testing, and implementation of innovative interventions and educational programs that can improve PCPs' genetic testing knowledge, assuage concerns about the appropriateness of cancer genetic testing, and promote open and effective patientprovider communication about genetic risk and genetic testing.

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“…Occasionally, individuals cannot return to clinic, and telephone/video conferencing is used as is done in other hereditary cancer genetics disclosure scenarios without adverse effects. 69,70 We also provide a "Family Letter" written in lay language summarizing our HMMS risk assessment, genetic testing results, recommendations for screening or follow-up care, and potential risk to and/or need for testing of additional family members. This letter is written for distribution to at-risk family members and the patient's primary care and other physicians.…”

Section: Case 1 (Continued)mentioning

confidence: 99%

How I diagnose and manage individuals at risk for inherited myeloid malignancies

Churpek

Godley

2016

Blood

148

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Although inherited hematopoietic malignancies have been reported clinically since the early twentieth century, the molecular basis for these diseases has only recently begun to be elucidated. Growing utilization of next-generation sequencing technologies has facilitated the rapid discovery of an increasing number of recognizable heritable hematopoietic malignancy syndromes while also deepening the field’s understanding of the molecular mechanisms that underlie these syndromes. Because individuals with inherited hematopoietic malignancies continue to be underdiagnosed and are increasingly likely to be encountered in clinical practice, clinicians need to have a high index of suspicion and be aware of the described syndromes. Here, we present the methods we use to identify, test, and manage individuals and families suspected of having a hereditary myeloid malignancy syndrome. Finally, we address the areas of ongoing research in the field and encourage clinicians and researchers to contribute and collaborate.

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Expanding Access to BRCA1/2 Genetic Counseling with Telephone Delivery: A Cluster Randomized Trial

Cited by 111 publications

References 52 publications

Cluster-randomised non-inferiority trial comparing DVD-assisted and traditional genetic counselling in systematic population testing for BRCA1/2 mutations

Cluster-randomised non-inferiority trial comparing DVD-assisted and traditional genetic counselling in systematic population testing for BRCA1/2 mutations

Primary care providers’ cancer genetic testing-related knowledge, attitudes, and communication behaviors: A systematic review and research agenda

How I diagnose and manage individuals at risk for inherited myeloid malignancies

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