Expanded Spectrum of Congenital Ocular Findings in Microcephaly with Presumed Zika Infection

Miranda, Homero Augusto de; Costa, Marcelo Cavalcante; Frazão, Maria Auxiliadora Monteiro; Simão, Natália; Franchischini, Sandra; Moshfeghi, Darius M.

doi:10.1016/j.ophtha.2016.05.001

Cited by 128 publications

(105 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[21][22][23][24][25] Musculoskeletal, Genitourinary, and Pulmonary Abnormalities Musculoskeletal abnormalities are frequently described in published reports of CZS, but their actual prevalence among infants of women infected during pregnancy remains unknown. Schwartz 9 analyzed 9 reported autopsies of fetuses and infants with intrauterine ZIKV infection and congenital microcephaly; of which 6 had variable findings of craniofacial malformations, craniosynostosis, and limb abnormalities, which included contractures of multiple joints or arthrogryposis.…”

Section: Ocular Abnormalitiesmentioning

confidence: 99%

Zika Virus Infection in Pregnancy, Microcephaly, and Maternal and Fetal Health: What We Think, What We Know, and What We Think We Know

M¹,

Schwartz

2016

Archives of Pathology &Amp; Laboratory Medicine

117

113

View full text Add to dashboard Cite

Context.-The global epidemic of Zika virus (ZIKV) infection has emerged as an important public health problem affecting pregnant women and their infants.Objectives.-To review the causal association between ZIKV infection during pregnancy and intrauterine fetal infection, microcephaly, brain damage, congenital malformation syndrome, and experimental laboratory models of fetal infection. Many questions remain regarding the risk factors, pathophysiology, epidemiology, and timing of maternal-fetal transmission and disease. These include mechanisms of fetal brain damage and microcephaly; the role of covariables, such as viral burden, duration of viremia, and host genetics, on vertical transmission; and the clinical and pathologic spectrum of congenital Zika syndrome. Additional questions include defining the potential long-term physical and neurobehavioral outcomes for infected infants, whether maternal or fetal host genetics influence the clinical outcome, and whether ZIKV infection can cause maternal morbidity. Finally, are experimental laboratory and animal models of ZIKV infection helpful in addressing maternal-fetal viral transmission and the development of congenital microcephaly? This communication provides current information and attempts to address some of these important questions.Data Sources.-Comprehensive review of published scientific literature.Conclusions.-Recent advances in epidemiology, clinical medicine, pathology, and experimental studies have provided a great amount of new information regarding vertical ZIKV transmission and the mechanisms of congenital microcephaly, brain damage, and congenital Zika syndrome in a relatively short time. However, much work still needs to be performed to more completely understand the maternal and fetal aspects of this new and emerging viral disease.

show abstract

Section: Ocular Abnormalitiesmentioning

confidence: 99%

Zika Virus Infection in Pregnancy, Microcephaly, and Maternal and Fetal Health: What We Think, What We Know, and What We Think We Know

M¹,

Schwartz

2016

Archives of Pathology &Amp; Laboratory Medicine

117

113

View full text Add to dashboard Cite

show abstract

“…Vision-threatening ocular symptoms include segmental pigmentation of the retina, chorioretinal and optic nerve atrophy, enlargement of optic disc cupping, hemorrhagic retinopathy, and abnormal retinal vasculature in children with microcephaly (58)(59)(60). Other signs in these patients include clubfoot and contracture of solitary or several joints (arthrogryposis), resulting in CNS impairment (61).…”

Section: Intrauterine and Congenital Infectionmentioning

confidence: 99%

Zika Virus, Congenital Infection, and Neurologic Manifestations in Children: A Narrative Review

Karimi

Razavi

2017

J Pediatr Rev

View full text Add to dashboard Cite

Context: Zika virus (ZIKV) is an arbovirus of the family Flaviviridae. This virus, which is transmitted by mosquitoes, usually affects children and causes self-limited diseases, associated with fever, maculopapular rash, conjunctivitis, arthralgia, and myalgia. There is a significant relationship between ZIKV infection and central nervous system disorders in infants. In this study, we aimed to review neurologic manifestations of ZIKV infection in infants. Evidence Acquisition: We searched the following Mesh terms in scientific databases: "Zika virus", "infants", "children", "neurologic manifestations", and "congenital infection". Electronic databases including Google Scholar, Science Direct, PubMed, Web of Science, Scientific Information Database, and Scopus were searched from 2000 to 2016. Results:The literature review showed a probable relationship between ZIKV infection and prevalence of microcephaly in newborns. Besides microcephaly, other central nervous system abnormalities included abnormal gyral arrangement, decreased brain parenchymal volume, cortical atrophy and malformation, cerebellar hypoplasia, and delayed myelination of the brain stem. Conclusions: Vertical transmission of ZIKV in pregnant women is associated with intrauterine infection and brain malformations in the developing fetus, including microcephaly, calcification, cortical displacement, ventriculomegaly, and white-matter abnormalities.

show abstract

“…Infection of these cell populations with Zika results in dysregulation of the cell cycle and in attenuation of neural development (Cugola et al, 2016;Li et al, 2016;Tang et al, 2016). In Zika-infected fetuses, ocular abnormalities, intrauterine growth restriction, and fetal demise have also been reported (Brasil et al, 2016;de Miranda et al, 2016;de Paula Freitas et al, 2016;Mlakar et al, 2016;Sarno et al, 2016).…”

Section: Exposurementioning

confidence: 99%

The Zika virus in the United States: A comprehensive review

Lindsey

Greenberg

2016

JGPHA

View full text Add to dashboard Cite

Background: With a series of outbreaks spanning the globe, the Zika virus has transitioned, in a short time, from an obscure virus to a public health emergency. Locally transmitted Zika has reached the United States, leading to increased concern regarding further transmission and the potential impact on public health. Methods:The present study was conducted to examine the propagation and effects of Zika in the United States by reviewing published literature regarding Zika in conjunction with updates from the Centers for Disease Control and Prevention. To gauge the regional response, including prevention and control efforts, interviews were conducted with public health and mosquito control officials.Results: Exposure to Zika may be through vectors, sexual activity with an infected partner, or congenitally to the unborn fetus. Regardless of the mode of transmission, Zika infection may result in serious neurological consequences in adults and especially in fetuses. Conclusions:Prevention of Zika infection is key to successful control of the virus. Vector control and surveillance as well as personal protection from virus exposure are necessary to avoid the potentially devastating effects of the virus. In an effort to prevent further spread, public health authorities are implementing strategies for public education, prevention, and containment.

show abstract

Expanded Spectrum of Congenital Ocular Findings in Microcephaly with Presumed Zika Infection

Cited by 128 publications

References 24 publications

Zika Virus Infection in Pregnancy, Microcephaly, and Maternal and Fetal Health: What We Think, What We Know, and What We Think We Know

Zika Virus Infection in Pregnancy, Microcephaly, and Maternal and Fetal Health: What We Think, What We Know, and What We Think We Know

Zika Virus, Congenital Infection, and Neurologic Manifestations in Children: A Narrative Review

The Zika virus in the United States: A comprehensive review

Contact Info

Product

Resources

About