2020
DOI: 10.1128/msystems.00299-20
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Expanded Phylogenetic Diversity and Metabolic Flexibility of Mercury-Methylating Microorganisms

Abstract: Methylmercury is a potent bioaccumulating neurotoxin that is produced by specific microorganisms that methylate inorganic mercury. Methylmercury production in diverse anaerobic bacteria and archaea was recently linked to the hgcAB genes. However, the full phylogenetic and metabolic diversity of mercury-methylating microorganisms has not been fully unraveled due to the limited number of cultured experimentally verified methylators and the limitations of primer-based molecular methods. Here, we describe the phyl… Show more

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Cited by 65 publications
(111 citation statements)
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References 116 publications
(209 reference statements)
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“…Some syntrophic microbes were recently suggested to be involved in the Hg methylation process (Gilmour et al, 2013;Yu et al, 2018;Hu et al, 2020), but we did not identify hgcAB genes from known syntrophic microorganisms in the Baltic Sea. Instead, we identified hgcAB-carrying bacteria closely related to various groups that are still poorly described (McDaniel et al, 2020) including members of Spirochaetes and Kiritimatiellaeota phyla. For instance, among the predominant hgcAB-like genes detected in Baltic Sea, the hgcAB genes BARM-01, -07 & -09 were clustered together and found close to a number of Spirochaetes (Figure 3).…”
Section: Discussionmentioning
confidence: 97%
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“…Some syntrophic microbes were recently suggested to be involved in the Hg methylation process (Gilmour et al, 2013;Yu et al, 2018;Hu et al, 2020), but we did not identify hgcAB genes from known syntrophic microorganisms in the Baltic Sea. Instead, we identified hgcAB-carrying bacteria closely related to various groups that are still poorly described (McDaniel et al, 2020) including members of Spirochaetes and Kiritimatiellaeota phyla. For instance, among the predominant hgcAB-like genes detected in Baltic Sea, the hgcAB genes BARM-01, -07 & -09 were clustered together and found close to a number of Spirochaetes (Figure 3).…”
Section: Discussionmentioning
confidence: 97%
“…The two procedures resulted in the recovery of the same hgcA genes and hgcAB gene clusters from the BARM dataset. For phylogenetic analysis, we used the amino acid sequences of the 650 hgcAB gene clusters identified as putative Hg methylators by McDaniel et al (2020). These 650 hgcAB gene clusters were obtained from the analysis of publicly available isolate genomes and metagenome-assembled genomes (Supplementary Datasheet S2, McDaniel et al, 2020).…”
Section: Methodsmentioning
confidence: 99%
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