Expanded Möbius syndrome

Symmetrical Thalamic Lesions in the Newborn: A Case Series

“…11,16 There may be some histopathological overlap with Möebius's syndrome. 6 This is in agreement with our autopsy data.…”

“…Also, both nuclei of the facial nerve were severely damaged. Cases 6 and 7 show some overlap with expanded Möbius's syndrome as described by Peleg et al 6…”

Congenital unilateral multiple cranial neuropathy: An etiology shared with Mobius syndrome?

“…Vascular insufficiency during fetal development leading to ischemic/hypoxic injury to just one side of the brainstem could account for the multiple unilateral palsies. Brainstem hypoplasia has been reported in other cases of Mobius syndrome, [11][12][13] including unilateral hypoplasia, where the idea of intra-uterine hypoxia leading to brainstem damage was entertained [9]. Calcification of affected cranial nerve nuclei seen at autopsy in the brainstem of Mobius patients provides further evidence of ischemia leading to destruction of nuclei and consequent loss of cranial nerve function [14].…”

Erstkontakt und strategisches Vorgehen bei Patienten mit seltener Erkrankung

“…Es wird in der Literatur als zumeist beidseitige Facialis-Abducens-Parese beschrieben, wobei auch andere Hirnnerven betroffen sein können. Symptomatisch zeigen Betroffene ein unbewegliches und ausdruckloses Gesicht [37,38]. Der maskenhafte Gesichtsausdruck mit dem Unvermögen, Gefühle wie Zorn, Glück oder Freude nonverbal zu vermitteln, kann zu Einschränkungen in der Entwicklung führen.…”