Abstract:Understanding early amyloidogenesis is key to rationally develop therapeutic strategies. Tau protein forms well-characterized pathological deposits but its aggregation mechanism is still poorly understood. Using single-molecule force spectroscopy based on a mechanical protection strategy, we studied the conformational landscape of the monomeric tau repeat domain (tau-RD 244-368 ). We found two sets of conformational states, whose frequency is influenced by mutations and the chemical context. While pathological… Show more
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