Expanded access protocol for the use of tecovirimat for the treatment of monkeypox infection

Olliaro, Piero; Bourner, Josephine

doi:10.1186/isrctn43307947

Cited by 2 publications

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“…Vaccination with vaccinia vaccine is not recommended for those with certain medical conditions, including severe allergies, immunosuppression, pregnancy, breastfeeding, preexisting heart disease, and a background of atopic dermatitis (AD) or the other exfoliative skin disease. 74,75 Alternative suggested treatment includes administration of antiviral like tecovirimat which is approved antiviral in the treatment of smallpox, particularly adults patients. Antiviral brincidofovir, used for treating severe smallpox viruses for both children and adults, is undergoing evaluation for EA-IND used in treating monkeypox.…”

Section: First Line Defencementioning

confidence: 99%

Monkeypox Viruses: Resurgence of Global Threat to Mankind

Manju¹,

Ranjini²,

Raj³

et al. 2022

J. Pure Appl. Microbiol.

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The unprecedented outbreaks of monkeypox viruses in non-endemic regions have created grave concern for global health. The World Health Organization has declared a public health emergency of international concern and stated the seriousness of monkeypox viruses. The gravity of this zoonotic disease cannot be underestimated, owing to the fact that this viral infection can cause pathetic situations if ignored. Keeping these lacunas, the scientific communities have expressed their interest towards the study of monkeypox viruses. Hence the present review discusses the etiological features, historical events, and vaccination along with management strategies to combat and counter the sudden outbreak. The review also highlights the current Indian scenario of the monkeypox virus; with scanty reports available, the present contributes towards the growing scientific knowledge to prevent a future threats to mankind.

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Section: First Line Defencementioning

confidence: 99%

Monkeypox Viruses: Resurgence of Global Threat to Mankind

Manju¹,

Ranjini²,

Raj³

et al. 2022

J. Pure Appl. Microbiol.

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A Comprehensive Review on the Transmission, Pathogenesis, and Prevention of Monkey Pox

Sharma,

Bala

et al. 2024

RJPPD

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Manily the cases of monkeypox connected to the 2022 breakout are being reported in nations throughout Europe and the Western Hemisphere, where it was formerly endemic to parts of Africa. Numerous groups are working on contact-tracing initiatives, but it is still unclear what started this outbreak. The monkeypox virus disease is a zoonotic viruses is a member of the orthopoxvirus genus and belonging to family poxiviridae. Following the eradication of smallpox worldwide in the 1970s, occurrences of monkeypox attracted attention on a global scale. The monkeypox virus could be protected against by the smallpox vaccine. Monkeypox instances increased once the smallpox vaccine was no longer administered. Monkeypox did not really receive widespread notice until the 2003 US outbreak. Despite the name "monkeypox," the virus did not originate in monkeys. The virus has been linked to a numeral of rodents and small animals, but the exact source of monkeypox is still unknown. The viral infection was originally noticed in macaque monkeys, hence the term "monkeypox." Although transmission of monkeypox from person to person is extremely uncommon, it is frequently assign to respiratory secretions or closely contacted with mucocutaneous abrasion of the contaminated person. Now present no designated cure for contaminated person, although supportive therpy may be used to relieve symptoms; in extremely severe cases, medications such tecovirimat may be used. Because there are no precise recommendations for symptom alleviation, many treatments are arbitrary. In light of the current outbreaks worldwide, we provide updated information on monkeypox for healthcare professionals in this review.

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Expanded access protocol for the use of tecovirimat for the treatment of monkeypox infection

Cited by 2 publications

References 0 publications

Monkeypox Viruses: Resurgence of Global Threat to Mankind

Monkeypox Viruses: Resurgence of Global Threat to Mankind

A Comprehensive Review on the Transmission, Pathogenesis, and Prevention of Monkey Pox

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