Exotic magnetic properties and enhanced magnetoelectric coupling in Fe3O4-BaTiO3 heterostructures

Revathy, Ramany; Kalarikkal, Nandakumar; Varma, Manoj Raama; Surendran, Kuzhichalil Peethambharan

doi:10.1016/j.jallcom.2021.161667

Cited by 11 publications

(7 citation statements)

References 84 publications

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“…This value is equal to 0.28 V/cm�Oe for an 80 nm CFO-BTO nanoparticle with 60:40 core to shell ratio and about one order of magnitude lower (i.e., 0.032 V/cm Oe) for a FO-BTO nanoparticle of the same dimension and core-shell composition. Both those values agree with magnetoelectric coefficients estimated on nanoparticles of similar sizes [16,28,53,54] and are about one order of magnitude higher than experimental values [20,55]. This discrepancy is due to the not perfect coupling between the two phases at the interface, which is not accounted when using ideal parameters and perfectly matching boundary conditions as in the simulations [56].…”

Section: Plos Onesupporting

confidence: 80%

“…The most common composite used in these early applications of MENPs is made of a combination of cobalt ferrite (CFO) and barium titanate (BTO) due to its good biocompatibility and high magnetoelectric coupling coefficient even at room temperature [14,15], but other compounds such as iron oxide (FO)/BTO and Nickel/BTO are emerging as possible valuable candidates to broad the use cases [16].…”

Section: Introductionmentioning

confidence: 99%

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Modeling of core-shell magneto-electric nanoparticles for biomedical applications: Effect of composition, dimension, and magnetic field features on magnetoelectric response

et al. 2022

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The recent development of core-shell nanoparticles which combine strain coupled magnetostrictive and piezoelectric phases, has attracted a lot of attention due to their ability to yield strong magnetoelectric effect even at room temperature, thus making them a promising tool to enable biomedical applications. To fully exploit their potentialities and to adapt their use to in vivo applications, this study analyzes, through a numerical approach, their magnetoelectric behavior, shortly quantified by the magnetoelectric coupling coefficient (αME), thus providing an important milestone for the characterization of the magnetoelectric effect at the nanoscale. In view of recent evidence showing that αME is strongly affected by both the applied magnetic field DC bias and AC frequency, this study implements a nonlinear model, based on magnetic hysteresis, to describe the responses of two different core-shell nanoparticles to various magnetic field excitation stimuli. The proposed model is also used to evaluate to which extent realistic variables such as core diameter and shell thickness affect the electric output. Results prove that αME of 80 nm cobalt ferrite-barium titanate (CFO-BTO) nanoparticles with a 60:40 ratio is equal to about 0.28 V/cm∙Oe corresponding to electric fields up to about 1000 V/cm when a strong DC bias is applied. However, the same electric output can be obtained even in absence of DC field with very low AC fields, by exploiting the hysteretic characteristics of the same composites. The analysis of core and shell dimension is as such to indicate that, to maximize αME, larger core diameter and thinner shell nanoparticles should be preferred. These results, taken together, suggest that it is possible to tune magnetoelectric nanoparticles electric responses by controlling their composition and their size, thus opening the opportunity to adapt their structure on the specific application to pursue.

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Section: Plos Onesupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Modeling of core-shell magneto-electric nanoparticles for biomedical applications: Effect of composition, dimension, and magnetic field features on magnetoelectric response

et al. 2022

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“…One of the most common composites used in these efforts is a cobalt ferrite (CFO) and barium titanate (BTO) core-shell conjugate (CFO-BTO) due to its high magnetoelectric coupling coefficient and relatively low toxicity, but other emerging composites such as BTO/iron oxide 49,50 (α = 28.78 mV/cm•Oe), cobalt-doped BiFeO 3 51,52 (α = 6.5 V/cm•Oe), CFO/BTO/polydopamine-P(VDF-TrFE) 53 (α E33 = 150.58 mV/cm•Oe), and BTO/nickel 54 (α = 225 µV/cm•Oe) are paving the way to an expanded toolkit of magnetoelectric probes and sensors. With appropriate biocompatible surface functionalization, new magnetoelectric compounds are expanding usability and improving safety for both SPIONs and MENPs for MPI [55][56][57] .…”

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confidence: 99%

In silico assessment of electrophysiological neuronal recordings mediated by magnetoelectric nanoparticles

Bok

Haber

et al. 2022

Sci Rep

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Magnetoelectric materials hold untapped potential to revolutionize biomedical technologies. Sensing of biophysical processes in the brain is a particularly attractive application, with the prospect of using magnetoelectric nanoparticles (MENPs) as injectable agents for rapid brain-wide modulation and recording. Recent studies have demonstrated wireless brain stimulation in vivo using MENPs synthesized from cobalt ferrite (CFO) cores coated with piezoelectric barium titanate (BTO) shells. CFO–BTO core–shell MENPs have a relatively high magnetoelectric coefficient and have been proposed for direct magnetic particle imaging (MPI) of brain electrophysiology. However, the feasibility of acquiring such readouts has not been demonstrated or methodically quantified. Here we present the results of implementing a strain-based finite element magnetoelectric model of CFO–BTO core–shell MENPs and apply the model to quantify magnetization in response to neural electric fields. We use the model to determine optimal MENPs-mediated electrophysiological readouts both at the single neuron level and for MENPs diffusing in bulk neural tissue for in vivo scenarios. Our results lay the groundwork for MENP recording of electrophysiological signals and provide a broad analytical infrastructure to validate MENPs for biomedical applications.

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“…3E are consistent with the crystal phases of Fe 3 O 4 and standard XRD data for Fe 3 O 4 (JCPDS card: 01-075-0033). 26 After PEG coating, the UV-Vis spectrum showed a slight red shift (527 nm). The antibody-conjugated NPs also showed a slight increase in the maximum absorption peak and a redshift of ~5 nm.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of actively HER-2 Targeted Fe₃O₄@Au nanoparticles for molecular radiosensitization of breast cancer

et al. 2022

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Introduction: The present study was done to assess the effect of molecularly-targeted core/shell of iron oxide/gold nanoparticles (Fe3O4@AuNPs) on tumor radiosensitization of SKBr-3 breast cancer cells. Methods: Human epidermal growth factor receptor-2 (HER-2)-targeted Fe3O4@AuNPs were synthesized by conjugating trastuzumab (TZ, Herceptin) to PEGylated (PEG)-Fe3O4@AuNPs (41.5 nm). First, the Fe3O4@Au core-shell NPs were decorated with PEG-SH to synthesize PEG-Fe3O4@AuNPs. Then, the TZ was reacted to OPSS-PEG-SVA to conjugate with the PEG-Fe3O4@AuNPs. As a result, structure, size and morphology of the developed NPs were assessed using Fourier-transform infrared (FT-IR) spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM), and ultraviolet-visible spectroscopy. The SKBr-3 cells were treated with different concentrations of TZ, Fe3O4@Au, and TZ-PEG-Fe3O4@AuNPs for irradiation at doses of 2, 4, and 8 Gy (from X-ray energy of 6 and 18 MV). Cytotoxicity was assessed by MTT assay, BrdU assay, and flow cytometry. Results: Results showed that the targeted TZ-PEG-Fe3O4@AuNPs significantly improved cell uptake. The cytotoxic effects of all the studied groups were increased in a higher concentration, radiation dose and energy-dependent manner. A combination of TZ, Fe3O4@Au, and TZ-PEG-Fe3O4@AuNPs with radiation reduced cell viability by 1.35 (P=0.021), 1.95 (P=0.024), and 1.15 (P=0.013) in comparison with 8 Gy dose of 18 MV radiation alone, respectively. These amounts were obtained as 1.27, 1.58, and 1.10 for 8 Gy dose of 6 MV irradiation, respectively. Conclusion: Radiosensitization of breast cancer to mega-voltage radiation therapy with TZ-PEG-Fe3O4@AuNPs was successfully obtained through an optimized therapeutic approach for molecular targeting of HER-2.

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Exotic magnetic properties and enhanced magnetoelectric coupling in Fe3O4-BaTiO3 heterostructures

Cited by 11 publications

References 84 publications

Modeling of core-shell magneto-electric nanoparticles for biomedical applications: Effect of composition, dimension, and magnetic field features on magnetoelectric response

Modeling of core-shell magneto-electric nanoparticles for biomedical applications: Effect of composition, dimension, and magnetic field features on magnetoelectric response

In silico assessment of electrophysiological neuronal recordings mediated by magnetoelectric nanoparticles

Synthesis and characterization of actively HER-2 Targeted Fe₃O₄@Au nanoparticles for molecular radiosensitization of breast cancer

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Exotic magnetic properties and enhanced magnetoelectric coupling in Fe3O4-BaTiO3 heterostructures

Cited by 11 publications

References 84 publications

Modeling of core-shell magneto-electric nanoparticles for biomedical applications: Effect of composition, dimension, and magnetic field features on magnetoelectric response

Modeling of core-shell magneto-electric nanoparticles for biomedical applications: Effect of composition, dimension, and magnetic field features on magnetoelectric response

In silico assessment of electrophysiological neuronal recordings mediated by magnetoelectric nanoparticles

Synthesis and characterization of actively HER-2 Targeted Fe3O4@Au nanoparticles for molecular radiosensitization of breast cancer

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Synthesis and characterization of actively HER-2 Targeted Fe₃O₄@Au nanoparticles for molecular radiosensitization of breast cancer