Exosomes—the enigmatic regulators of bone homeostasis

Gao, Minhao; Gao, Weiyang; Papadimitriou, J. M.; Zhang, Changqing; Gao, Junjie; Zheng, Minghao

doi:10.1038/s41413-018-0039-2

Cited by 89 publications

(78 citation statements)

References 170 publications

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“…59 To date, cumulative evidence has revealed that exosomes participate in many biological processes, including angiogenesis, cell differentiation, immunomodulation, metabolic balance, and development, 24,26,[60][61][62] and are highly involved in many diseases, such as cancer, neurodegenerative disease, autoimmune diseases, and cardiovascular diseases. [63][64][65][66][67][68][69][70][71][72][73] Recently, the roles of exosomes in bone homeostasis have been extensively addressed. 73 Bone homeostasis is primarily maintained by bone resorption and bone formation, which are involved in various types of cells, including osteoblasts, osteoclasts, osteocytes, and MSCs.…”

Section: Exosomementioning

confidence: 99%

Exosomes: roles and therapeutic potential in osteoarthritis

Ni¹,

et al. 2020

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Exosomes participate in many physiological and pathological processes by regulating cell-cell communication, which are involved in numerous diseases, including osteoarthritis (OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint cells, including chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and secrete exosomes that influence the biological effects of targeted cells. In addition, exosomes from stem cells can protect the OA joint from damage by promoting cartilage repair, inhibiting synovitis, and mediating subchondral bone remodeling. This review summarizes the roles and therapeutic potential of exosomes in OA and discusses the perspectives and challenges related to exosome-based treatment for OA patients in the future.

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Section: Exosomementioning

confidence: 99%

Exosomes: roles and therapeutic potential in osteoarthritis

Ni¹,

et al. 2020

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“…Fortunately, recent decades witness the conceptual progress of bone biology, which in turn contributes to new therapeutic strategies managing bone loss diseases [3,4]. Bone formation and resorption are viewed as two major events during bone regeneration [5]. Based on this conception, bone anabolic treatments and antiresorption ways were introduced individually [1,6].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Application of Platelet-Rich Fibrin and 1% Alendronate in Periodontal Bone Regeneration: A Meta-Analysis

Jiang

Pan

et al. 2019

BioMed Research International

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Periodontal bone regeneration relies on coupled and cooperative bone formation and resorption. Accordingly a novel strategy on concurrent use of platelet-rich fibrin (PRF) (anabolic agent) and 1% alendronate (ALN) (anticatabolic agent) was proposed recently in regenerative periodontal treatment. It was supposed to enhance bone formation and reduce bone resorption simultaneously. However, there is a lack of evidence-based studies to answer whether this concurrent application was superior to single application until now. Besides, concerns on ALN lead to some reservation on this synergistic way. ALN may impair new bone formation and necrotize jaws. Thus, in order to compare the clinical efficacy between PRF plus 1%ALN and PRF alone on periodontal bone regeneration, we performed present systematic review and meta-analysis. Because it is the prerequisite for measuring the combined efficacy of PRF plus 1%ALN, firstly we evaluated the effectiveness of 1%ALN. Our data indicated that adjunctive 1%ALN was effective in promoting periodontal bone repair. Further, PRF plus 1%ALN showed a greater capacity for periodontal regeneration than PRF alone with statistical significance. The findings of this study revealed the promising prospects on synergistic application of bone anabolic agents (PRF) and antiresorption medications (1%ALN) in regenerative periodontal treatment.

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“…Our results indicated that exosomal miRNAs may play a vital role in enhancing cartilage regeneration. Extracellular vesicles can be ingested more rapidly by homotypic cells, as opposed to other cells [49]. We believe that the combination of CPC-EVs will serve as excellent "inducing factors" to the repair of clinical OA.…”

Section: Discussionmentioning

confidence: 96%

Intra-articular delivery of extracellular vesicles secreted by chondrogenic progenitor cells from MRL/MpJ superhealer mice enhances articular cartilage repair in a mouse injury model

et al. 2020

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Background: Chondrogenic progenitor cells (CPCs) have high self-renewal capacity and chondrogenic potential. Intra-articular delivery of purified mesenchymal stem cells (MSCs) from MRL/MpJ "superhealer" mice increased bone volume during repair and prevents post-traumatic arthritis. Recently, although extracellular vesicles released from MSCs have been used widely for treating OA, the application of extracellular vesicles secreted by CPCs from MRL/ MpJ mice in OA therapy has never been reported. In this study, we evaluated the effects of extracellular vesicles secreted by CPCs from control CBA (CBA-EVs) and MRL/MpJ mice (MRL-EVs) on proliferation and migration of murine chondrocytes. We also determined here if weekly intra-articular injections of CBA-EVs and MRL-EVs would repair and regenerate surgically induced model in mice. Methods: CPC surface markers were detected by flow cytometry. CBA-EVs and MRL-EVs were isolated using an ultrafiltration method. Nanoparticle tracking analysis, transmission electron microscopy, and western blots were used to identify extracellular vesicles. CBA-EVs and MRL-EVs were injected intra-articularly in a mouse model of surgical destabilization of the medial meniscus (DMM)-induced OA, and histological and immunohistochemistry analyses were used to assess the efficacy of exosome injections. We used miRNA-seq analysis to analyze the expression profiles of exosomal miRNAs derived from CBA-EVs as well as MRL-EVs. Cell-counting and scratch assays were used to evaluate the effects of CBA-EVs and MRL-EVs on proliferation and migration of murine chondrocytes, respectively. Meanwhile, a specific RNA inhibitor assesses the roles of the candidate miRNAs in CPC-EV-induced regulation of function of chondrocytes.

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Exosomes—the enigmatic regulators of bone homeostasis

Cited by 89 publications

References 170 publications

Exosomes: roles and therapeutic potential in osteoarthritis

Exosomes: roles and therapeutic potential in osteoarthritis

Synergistic Application of Platelet-Rich Fibrin and 1% Alendronate in Periodontal Bone Regeneration: A Meta-Analysis

Intra-articular delivery of extracellular vesicles secreted by chondrogenic progenitor cells from MRL/MpJ superhealer mice enhances articular cartilage repair in a mouse injury model

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