Exosomes in the serum of Acute Myeloid Leukemia patients induce dendritic cell tolerance: Implications for immunotherapy

Benites, Bruno Deltreggia; Duarte, Adriana da Silva Santos; Longhini, Ana Leda; Santos, Irene; Álvarez, María Inés Ortíz; Ribeiro, Lígia Nunes de Morais; Paula, Eneida de; Saad, Sara Teresinha Olalla

doi:10.1016/j.vaccine.2019.01.079

Cited by 20 publications

(28 citation statements)

References 18 publications

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“…The authors confirmed the capability of exosomes in improving DC pulsing. Surprisingly, they observed that exosomes purified from culture media enhanced DC activation, inducing a higher level of target cell lysis than exosomes isolated from patients' plasma [156]. Thus, exosomes from cultured cell media may represent an effective way to develop vaccines based on maturing DCs, even if recent data suggest that there is probably a synergic effect between vesicular and soluble molecules [157].…”

Section: Small Evs As Potential Therapeutic Toolsmentioning

confidence: 99%

Exosomes and Extracellular Vesicles in Myeloid Neoplasia: The Multiple and Complex Roles Played by These “Magic Bullets”

Bernardi

Farina

2021

Biology

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Extracellular vesicles (exosomes, in particular) are essential in multicellular organisms because they mediate cell-to-cell communication via the transfer of secreted molecules. They are able to shuttle different cargo, from nucleic acids to proteins. The role of exosomes has been widely investigated in solid tumors, which gave us surprising results about their potential involvement in pathogenesis and created an opening for liquid biopsies. Less is known about exosomes in oncohematology, particularly concerning the malignancies deriving from myeloid lineage. In this review, we aim to present an overview of immunomodulation and the microenvironment alteration mediated by exosomes released by malicious myeloid cells. Afterwards, we review the studies reporting the use of exosomes as disease biomarkers and their influence in response to treatment, together with the recent experiences that have focused on the use of exosomes as therapeutic tools. The further development of new technologies and the increased knowledge of biological (exosomes) and clinical (myeloid neoplasia) aspects are expected to change the future approaches to these malignancies.

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Section: Small Evs As Potential Therapeutic Toolsmentioning

confidence: 99%

Exosomes and Extracellular Vesicles in Myeloid Neoplasia: The Multiple and Complex Roles Played by These “Magic Bullets”

Bernardi

Farina

2021

Biology

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“…Acute leukemia-derived EVs contain a variety of non-coding RNAs supporting leukemogenesis and influencing the outcome and response to therapy through the regulation of several genes involved in the pathogenesis of this disease [56] . In addition, several studies have highlighted the promising role of circulating miRs as biomarkers in acute myeloid leukemia (AML) ( Table 1 ) [4] , [34] , [74] , [82] , [85] . For instance, Marcucci and colleagues, by using nCounter assay, demonstrated that miR-155 overexpression was independently associated to poor prognosis in a large cohort of adult AML patients with normal karyotype [45] .…”

Section: Functional Interpretation Of Evs Content In Hmmentioning

confidence: 99%

High-throughput analysis and functional interpretation of extracellular vesicle content in hematological malignancies

Adamo

Kamga

Tanasi

et al. 2020

Computational and Structural Biotechnology Journal

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Extracellular vesicles (EVs) are membrane-coated particles secreted by virtually all cell types in response to different stimuli, both in physiological and pathological conditions . Their content generally reflects their biological functions and includes a variety of molecules, such as nucleic acids, proteins and cellular components. The role of EVs as signaling vehicles has been widely demonstrated. In particular, they are actively involved in the pathogenesis of several hematological malignancies (HM), mainly interacting with a number of target cells and inducing functional and epigenetic changes. In this regard, by releasing their cargo, EVs play a pivotal role in the bilateral cross-talk between tumor microenvironment and cancer cells, thus facilitating mechanisms of immune escape and supporting tumor growth and progression. Recent advances in high-throughput technologies have allowed the deep characterization and functional interpretation of EV content. In this review, the current knowledge on the high-throughput technology-based characterization of EV cargo in HM is summarized.

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“…MicroRNAs are one of the best biomarkers for cancer follow‐up, particularly in leukemia MRD detection 176 . A study on a mouse model by Hornick et al showed that, the genetic contents of EVs are reflecting from their parental cell, have been considered as prospective biomarkers in identification of cancer MRD 15,16 . A study on pediatric ALL showed that, circulating miRs (such as miR‐128‐3p, 181a‐5p, 181b‐5p, 222‐3p) and EVs containing microRNAs are beneficial biomarkers for detection of residual leukemia which are being tested by advanced qPCR 176 .…”

Section: The Role Of Exosomes As Potential Marker For Mrdmentioning

confidence: 99%

“…35,36 AML-derived exosomes also cause immune tolerance effect on DCs which are responsible for tumor evasion from the immune system. 16 These TDEs have inhibitory effect on DCs activities and their maturation, by TGF-β1. 37,38 The key role of exosomal TGF-β on immune system is presented in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Exosome: From leukemia progression to a novel therapeutic approach in leukemia treatment

et al. 2020

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Exosomes, as small vesicles, are released by tumor cells and tumor microenvironment (cells and function as key intercellular mediators and effects on different processes including tumorigenesis, angiogenesis, drug resistance, and evasion from immune system. These functions are due to exosomes' biomolecules which make them as efficient markers in early diagnosis of the disease. Also, exosomes have been recently applied in vaccination. The potential role of

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Exosomes in the serum of Acute Myeloid Leukemia patients induce dendritic cell tolerance: Implications for immunotherapy

Cited by 20 publications

References 18 publications

Exosomes and Extracellular Vesicles in Myeloid Neoplasia: The Multiple and Complex Roles Played by These “Magic Bullets”

Exosomes and Extracellular Vesicles in Myeloid Neoplasia: The Multiple and Complex Roles Played by These “Magic Bullets”

High-throughput analysis and functional interpretation of extracellular vesicle content in hematological malignancies

Exosome: From leukemia progression to a novel therapeutic approach in leukemia treatment

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