Exosomes in multidrug-resistant cancer

Kalyane, Dnyaneshwar; Choudhary, Devendra; Polaka, Suryanarayana; Goykar, Hanmant; Anup, Neelima; Tambe, Vishakha; Kalia, Kiran; Tekade, Rakesh K.

doi:10.1016/j.coph.2020.08.017

Current Opinion in Pharmacology

2020

DOI: 10.1016/j.coph.2020.08.017

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Exosomes in multidrug-resistant cancer

Dnyaneshwar Kalyane

Devendra Choudhary

Suryanarayana Polaka

et al.

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Cited by 5 publications

(1 citation statement)

References 73 publications

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“…Additionally, in the donor cells, chemoresistance occurs through reducing the intracellular drug concentration as well as discarding proapoptotic proteins (i.e., caspases). 2 , 4 , 5 …”

mentioning

confidence: 99%

Exosomes as versatile nanoscaled biocompartments in cancer therapy and/or resistance

Saadat

Barar

2022

Bioimpacts

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Cancer remains to be a major hurdle to global health. Exosomes as a versatile bio-derived platform, hold a bright prospect in nano-scaled delivery/targeting strategies. Shreds of evidence indicate that exosomes have a critical role in drug resistance in cancer cells through various mechanisms including shuttling of miRNAs, drug efflux transporters, and anti-apoptotic signaling. Exosomes’ cargo, particularly miRNAs, may exert both resistance and in a few cases sensitivity to the anticancer agents in targeted cells. Therefore, the source and components of the exosomes should be carefully considered before any application. Our aim in this editorial is to further highlight the role of exosomes in the development of resistance to therapy in cancer cells. As a new chapter for drug delivery, the challenges should be elucidated before exosomes emerge as novel nanoplatforms for cancer therapy.

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“…Additionally, in the donor cells, chemoresistance occurs through reducing the intracellular drug concentration as well as discarding proapoptotic proteins (i.e., caspases). 2 , 4 , 5 …”

mentioning

confidence: 99%

Exosomes as versatile nanoscaled biocompartments in cancer therapy and/or resistance

Saadat

Barar

2022

Bioimpacts

View full text Add to dashboard Cite

show abstract

Emerging technologies and commercial products in exosome-based cancer diagnosis and prognosis

Mohammadi

Zargartalebi

Salahandish

et al. 2021

Biosensors and Bioelectronics

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Editorial overview: New technologies in 2020: Drug resistance

Wong

2020

Current Opinion in Pharmacology

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Exosomes in multidrug-resistant cancer

Cited by 5 publications

References 73 publications

Exosomes as versatile nanoscaled biocompartments in cancer therapy and/or resistance

Exosomes as versatile nanoscaled biocompartments in cancer therapy and/or resistance

Emerging technologies and commercial products in exosome-based cancer diagnosis and prognosis

Editorial overview: New technologies in 2020: Drug resistance

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