Exosomes in bladder cancer: novel biomarkers and targets

Geng, Hao; Zhou, Qi; Guo, Wenhao; Lü, Ling; Bi, Liangkuan; Wang, Yi; Min, Jie; Yu, Dexin; Liang, Zhaofeng

doi:10.1631/jzus.b2000711

Cited by 11 publications

(4 citation statements)

References 38 publications

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“…Since exosomes play a key role in tumorigenesis, progression, and metastasis through transfer of carcinogenic molecules, studies on exosomal miRNAs, mRNA, and protein expression in patients with UC are now emerging in human medicine (21)(22)(23)34). Exosomal lymph node metastasis-associated transcript 2 from bladder cancer cells are known to induce lymphangiogenesis and lymphatic metastasis (35).…”

Section: Figure 2 Boxplots Of Expression Of Nmp-22 In the Exosomes De...mentioning

confidence: 99%

Changes in Urinary Exosomal Nuclear Matrix Protein-22 in Dogs With Urothelial Carcinoma: A Pilot Study

SHIN,

AN,

PARK

et al. 2023

In Vivo

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Background/Aim: Nuclear matrix protein-22 is widely used in human medicine as a prognostic and diagnostic tool for urothelial carcinoma (UC). In addition, the use of urinary exosomes as a liquid biopsy tool is emerging for the diagnosis of certain types of cancer in human medicine. This study aimed to investigate the change in urinary exosomal NMP-22 for the diagnosis of UC in dogs. Patients and Methods: Among canine patients who visited the veterinary hospital, urine was collected from those whose owners provided consent. A total of 23 dogs (UC group, n=6; control group, n=17) were included in the analysis. After exosomes were isolated from the urine, NMP-22 was measured using enzyme-linked immunosorbent assay. Results: In the UC group, the expression of NMP-22 in urinary exosomes was significantly higher than that in non-UC groups (p<0.0001). Conclusion: NMP-22 is significantly increased in exosomes in the urine of dogs diagnosed with UC, suggesting that urinary exosome NMP-22 can be considered as one of the liquid biopsy tools for diagnosing UC in dogs.

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Section: Figure 2 Boxplots Of Expression Of Nmp-22 In the Exosomes De...mentioning

confidence: 99%

Changes in Urinary Exosomal Nuclear Matrix Protein-22 in Dogs With Urothelial Carcinoma: A Pilot Study

SHIN,

AN,

PARK

et al. 2023

In Vivo

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“…A large number of studies have proved that exosome surface proteins, endogenous proteins and nucleic acids isolated from body fluids of various cancer patients are expected to be biomarkers for prediction, diagnosis, staging, radiotherapy and chemotherapy treatment response and prognosis [92], such as glioma [93]; Esophageal cancer [94]; Gastric cancer [95]; Pancreatic cancer [96,97]; Hepatocellular carcinoma [98]; Colorectal cancer [99]; Lung cancer [100]; Lung adenocarcinoma [101]. Non-small cell lung cancer [102]; Bladder cancer [103]; Prostate cancer [104]; Ovarian cancer [105,106]; Breast cancer [107], etc. Table 1 shows exosomes as biomarkers of breast cancer.…”

Section: Application Of Exosomes As Biomarkers In Breast Cancermentioning

confidence: 99%

Exosomes: Small Vesicles with Important Roles in the Development, Metastasis and Treatment of Breast Cancer

Meng

Song

et al. 2022

Membranes

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Breast cancer (BC) has now overtaken lung cancer as the most common cancer, while no biopredictive marker isolated from biological fluids has yet emerged clinically. After traditional chemotherapy, with the huge side effects brought by drugs, patients also suffer from the double affliction of drugs to the body while fighting cancer, and they often quickly develop drug resistance after the drug, leading to a poor prognosis. And the treatment of some breast cancer subtypes, such as triple negative breast cancer (TNBC), is even more difficult. Exosomes (Exos), which are naturally occurring extracellular vesicles (EVs) with nanoscale acellular structures ranging in diameter from 40 to 160 nm, can be isolated from various biological fluids and have been widely studied because they are derived from the cell membrane, have extremely small diameter, and are widely involved in various biological activities of the body. It can be used directly or modified to make derivatives or to make some analogs for the treatment of breast cancer. This review will focus on the involvement of exosomes in breast cancer initiation, progression, invasion as well as metastasis and the therapeutic role of exosomes in breast cancer.

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“…The role of exosomes in MIBC progression is not fully understood in current literature. It has been suggested that high quantity of exosomes from MIBC may attribute from the pro-cancer actions such as increased tumor growth, invasion, and angiogenesis [ 71 , 72 , 73 ]. Starting with proliferation, tumor-derived extracellular vesicles (TEVs) and exosomes alter the operations of tumor suppressor genes to create a protumor microenvironment [ 74 ].…”

Section: Exosomes In Muscle Invasive Bladder Cancermentioning

confidence: 99%

Applications of Exosomes in Diagnosing Muscle Invasive Bladder Cancer

Walker

O’Malley

2022

Pharmaceutics

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Muscle Invasive Bladder Cancer (MIBC) is a subset of bladder cancer with a significant risk for metastases and death. It accounts for nearly 25% of bladder cancer diagnoses. A diagnostic work-up for MIBC is inclusive of urologic evaluation, radiographic imaging with a CT scan, urinalysis, and cystoscopy. These evaluations, especially cystoscopy, are invasive and carry the risk of secondary health concerns. Non-invasive diagnostics such as urine cytology are an attractive alternative currently being investigated to mitigate the requirement for cystoscopy. A pitfall in urine cytology is the lack of available options with high reliability, specificity, and sensitivity to malignant bladder cells. Exosomes are a novel biomarker source which could resolve some of the concerns with urine cytology, due to the high specificity as the surrogates of tumor cells. This review serves to define muscle invasive bladder cancer, current urine cytology methods, the role of exosomes in MIBC, and exosomes application as a diagnostic tool in MIBC. Urinary exosomes as the specific populations of extracellular vesicles could provide additional biomarkers with specificity and sensitivity to bladder malignancies, which are a consistent source of cellular information to direct clinicians for developing treatment strategies. Given its strong presence and differentiation ability between normal and cancerous cells, exosome-based urine cytology is highly promising in providing a perspective of a patient’s bladder cancer.

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Exosomes in bladder cancer: novel biomarkers and targets

Cited by 11 publications

References 38 publications

Changes in Urinary Exosomal Nuclear Matrix Protein-22 in Dogs With Urothelial Carcinoma: A Pilot Study

Changes in Urinary Exosomal Nuclear Matrix Protein-22 in Dogs With Urothelial Carcinoma: A Pilot Study

Exosomes: Small Vesicles with Important Roles in the Development, Metastasis and Treatment of Breast Cancer

Applications of Exosomes in Diagnosing Muscle Invasive Bladder Cancer

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