Exosomes from human cord blood plasma accelerate cutaneous wound healing by promoting fibroblast function, angiogenesis, and M2 macrophage differentiation

Kim, Sueon; Kim, Yeongwon; Hyun, You-Seok; Choi, Hee-Baeg; Kim, Tai‐Gyu

doi:10.1039/d0bm01801e

Cited by 17 publications

(14 citation statements)

References 29 publications

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“…showed that human cord blood plasma EVs also promoted wound healing. Especially in EVs, heat shock protein 72 (HSP72) and prolactin-inducible proteins (PIPs) also promote differentiation from the proinflammatory M1-like phenotype to the anti-inflammatory M2-like phenotype, thus promoting the transition of wounds from inflammation to proliferation ( 110 ). Adjusting the EV/macrophage axis to reduce skin inflammation may become a new treatment approach for diabetes complicated with skin healing disorders in the future.…”

Section: Ev/macrophage Axis and Inflammatory Diseasesmentioning

confidence: 99%

Extracellular Vesicle/Macrophage Axis: Potential Targets for Inflammatory Disease Intervention

et al. 2022

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Extracellular vesicles (EVs) can regulate the polarization of macrophages in a variety of inflammatory diseases by mediating intercellular signal transduction and affecting the occurrence and development of diseases. After macrophages are regulated by EVs, they mainly show two phenotypes: the proinflammatory M1 type and the anti-inflammatory M2 type. A large number of studies have shown that in diseases such as mastitis, inflammatory bowel disease, Acute lung injury, and idiopathic pulmonary fibrosis, EVs promote the progression of the disease by inducing the M1-like polarization of macrophages. In diseases such as liver injury, asthma, and myocardial infarction, EVs can induce M2-like polarization of macrophages, inhibit the inflammatory response, and reduce the severity of the disease, thus indicating new pathways for treating inflammatory diseases. The EV/macrophage axis has become a potential target for inflammatory disease pathogenesis and comprehensive treatment. This article reviews the structure and function of the EV/macrophage axis and summarizes its biological functions in inflammatory diseases to provide insights for the diagnosis and treatment of inflammatory diseases.

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Section: Ev/macrophage Axis and Inflammatory Diseasesmentioning

confidence: 99%

Extracellular Vesicle/Macrophage Axis: Potential Targets for Inflammatory Disease Intervention

et al. 2022

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“…RBCEVs are critical for the dysregulation of hemostasis and exhibit associated procoagulant effects in several diseased states [ 54 ]. Exosomes from human cord blood plasma play an important role in wound healing by promoting angiogenesis and the differentiation of M2 macrophages, thereby facilitating the transition from inflammation to proliferation [ 57 ].…”

Section: Roles Of Rbcevs In Healthy and Diseased Statesmentioning

confidence: 99%

Roles and Applications of Red Blood Cell-Derived Extracellular Vesicles in Health and Diseases

Yang

Huang

Zhang

et al. 2022

IJMS

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Red blood cell-derived extracellular vesicles (RBCEVs) are vesicles naturally produced by red blood cells and play multiple roles such as acting as cell-to-cell communication messengers in both normal physiological and diseased states. RBCEVs are highly promising delivery vehicles for therapeutic agents such as biomolecules and nucleic acids as they are easy to source, safe, and versatile. RBCEVs autonomously target the liver and pass the blood–brain barrier into the brain, which is highly valuable for the treatment of liver and brain diseases. RBCEVs can be modified by various functional units, including various functional molecules and nanoparticles, to improve their active targeting capabilities for tumors or other sites. Moreover, the RBCEV level is significantly shifted in many diseased states; hence, they can also serve as important biomarkers for disease diagnoses. It is clear that RBCEVs have considerable potential in multiple medical applications. In this review, we briefly introduce the biological roles of RBCEVs, presented interesting advances in RBCEV applications, and discuss several challenges that need to be addressed for their clinical translation.

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“…In recent years, EVs have been widely used as natural delivery vehicles for intercellular nucleic acids, [ 3 ] proteins, [ 4 ] as well as drugs [ 5 ] aimed at modulating immune responses, [ 6 ] cell proliferation, [ 7 ] and angiogenesis. [ 8 ] EVs also have great clinical application potential against tumor cells, [ 9 ] promote bone regeneration, [ 10 ] and wound healing, [ 11 ] which are essential for the treatment of diseases such as diabetes, [ 12 ] spinal cord injury, [ 13 ] and heart injury. [ 14 ]…”

Section: Introductionmentioning

confidence: 99%

Extracellular Vesicle Mimetics: Preparation from Top‐Down Approaches and Biological Functions

Wang

Yang

et al. 2022

Adv Healthcare Materials

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Extracellular vesicles (EVs) have attracted attention as delivery vehicles due to their structure, composition, and unique properties in regeneration and immunomodulation. However, difficulties during production and isolation processes of EVs limit their large‐scale clinical applications. EV mimetics (EVMs), prepared via top‐down strategies that improve the yield of nanoparticles while retaining biological properties similar to those of EVs have been used to address these limitations. Herein, the preparation of EVMs is reviewed and their characteristics in terms of structure, composition, targeting ability, cellular uptake mechanism, and immunogenicity, as well as their strengths, limitations, and future clinical application prospects as EV alternatives are summarized.

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Exosomes from human cord blood plasma accelerate cutaneous wound healing by promoting fibroblast function, angiogenesis, and M2 macrophage differentiation

Abstract: Exosomes contain natural cargo molecules, such as miRNA, mRNA, and proteins, and transfer these functional cargos to neighboring or distant cells through circulation. In the wound-healing process, exosomes in human...

Cited by 17 publications

References 29 publications

Extracellular Vesicle/Macrophage Axis: Potential Targets for Inflammatory Disease Intervention

Extracellular Vesicle/Macrophage Axis: Potential Targets for Inflammatory Disease Intervention

Roles and Applications of Red Blood Cell-Derived Extracellular Vesicles in Health and Diseases

Extracellular Vesicle Mimetics: Preparation from Top‐Down Approaches and Biological Functions

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