Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis

Lei, Jinghui; Jiang, Xiaoyu; Li, Wei; Ren, Jie; Wang, Datao; Ji, Zhejun; Wu, Zeming; Cheng, Fang; Cai, Yusheng; Yu, Zhengrong; Belmonte, Juan Carlos Izpisúa; Li, Chunyi; Liu, Guang‐Hui; Zhang, Weiqi; Qu, Jing; Wang, Si

doi:10.1007/s13238-021-00860-9

Cited by 43 publications

(41 citation statements)

References 16 publications

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“…Similarly, we isolated dASCs from the amputation surface. dASCs have a higher self-renewal ability than human primary mesenchymal stem cells (hPMSCs) 6,7,16 (Fig. 1a and Supplementary Fig.…”

Section: Transcriptomic Analysis Revealing Convergent Metabolic Pathways In Models With Enhanced Regenerative Potentialsmentioning

confidence: 99%

“…Human ESC-derived hMSCs and antler stem cells were cultured on gelatin-coated plates in MSC culture medium containing α-MEM medium (Gibco) supplemented with 10% fetal bovine serum (FBS) (Gibco, Cat# 10099-141), 0.1 mM non-essential amino acids (Gibco), 1% penicillin/ streptomycin (Gibco) and 1 ng/mL bFGF (Joint Protein Central, Cat# BBI-EXP-002) 16,[60][61][62][63] .…”

Section: Cell Culturementioning

confidence: 99%

“…The axolotl can regenerate their limbs through the formation of blastema tissue, a mass of dedifferentiated stem cells 3,5,13 . Similarly, during annual regeneration, deer antler produces a whole organ containing blood vessels, cartilage, bone, dermis, and nerves from deer antler stem cells (dASCs) that express classic mesenchymal stem cell (MSC) markers and reside in the mid-beam antler periosteum 7,[14][15][16] . Compared to stem cells from regenerative tissues of the axolotl limb and the deer antler, human stem cells, such as human mesenchymal stem cells (hMSCs), possess a relatively limited capacity for regenerative repair of damages to vital tissues and organs 2,12 , but gradually lose such capacity with age.…”

Section: Introductionmentioning

confidence: 99%

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Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor

Liu

Geng

et al. 2022

Cell Discov

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Regenerative capacity declines throughout evolution and with age. In this study, we asked whether metabolic programs underlying regenerative capability might be conserved across species, and if so, whether such metabolic drivers might be harnessed to promote tissue repair. To this end, we conducted metabolomic analyses in two vertebrate organ regeneration models: the axolotl limb blastema and antler stem cells. To further reveal why young individuals have higher regenerative capacity than the elderly, we also constructed metabolic profiles for primate juvenile and aged tissues, as well as young and aged human stem cells. In joint analyses, we uncovered that active pyrimidine metabolism and fatty acid metabolism correlated with higher regenerative capacity. Furthermore, we identified a set of regeneration-related metabolite effectors conserved across species. One such metabolite is uridine, a pyrimidine nucleoside, which can rejuvenate aged human stem cells and promote regeneration of various tissues in vivo. These observations will open new avenues for metabolic intervention in tissue repair and regeneration.

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Section: Transcriptomic Analysis Revealing Convergent Metabolic Pathways In Models With Enhanced Regenerative Potentialsmentioning

confidence: 99%

Section: Cell Culturementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor

Liu

Geng

et al. 2022

Cell Discov

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“…Especially, as the only known mammalian organ that can be regenerated annually, the deer antler is an ideal organ to overcome the insufficiency of stem cells. Lei et al (2021) proved that the deer antler stem cell-derived exosomes could reduce inflammation, delay cell senescence, and promote bone and cartilage regeneration.…”

Section: Exosomes and Bone Diseasesmentioning

confidence: 99%

Research Progress of Exosomes in Bone Diseases: Mechanism, Diagnosis and Therapy

Meng

Xue

Yin

et al. 2022

Front. Bioeng. Biotechnol.

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With the global escalation of the aging process, the number of patients with bone diseases is increasing year by year. Currently, there are limited effective treatments for bone diseases. Exosome, as a vital medium in cell-cell communication, can mediate tissue metabolism through the paracrine transmission of various cargos (proteins, nucleic acids, lipids, etc.) carried by itself. Recently, an increasing number of researchers have proven that exosomes play essential roles in the formation, metabolism, and pathological changes of bone and cartilage. Because exosomes have the advantages of small size, rich sources, and low immunogenicity, they can be used not only as substitutes for the traditional treatment of bone diseases, but also as biomarkers for the diagnosis of bone diseases. This paper reviews the research progress of several kinds of cells derived-exosomes in bone diseases and provides a theoretical basis for further research and clinical application of exosomes in bone diseases in the future.

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“…Several therapeutical effects have been attributed to velvet antler for over 2000 years [13]. Among the latest confirmed effects are the anti-cancer effects both in cell cultures and animal models [14][15][16], and recently developed treatments to revert aging using cell components of velvet antlers [17]. Therefore, it is important to improve the economic benefits of sika deer velvet antler by reducing the feeding cost of male sika deer.…”

Section: Introductionmentioning

confidence: 99%

Velvet Antler Production and Hematological Changes in Male Sika Deers Fed with Spent Mushroom Substrate

Yuan

Tahir

et al. 2022

Animals

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At present, spent mushroom substrate (SMS) is a waste resource that is producing a pollution problem in China, and which has some use as animal feed or fertilizer, has not been assessed as a feed for deer. The purpose of this study is to expand the feed of male sika deer and reduce the feeding cost by using the waste resource of SMS. The 10% concentrated supplement was replaced with SMS and the feed intake, apparent digestibility, blood index and velvet production of male sika deer were measured. As the results showed, compared to the control group, the substitution of SMS for 10% of the concentrate supplement decreased the concentration of IgA (p < 0.01), replacing 10% concentrated supplement with SMS of Pleurotus ostreatus (SMS-MP) reduced the intake of organic matter (OMI) and improved the digestibility of ether extract (EE), while replacing 10% concentrated supplement with SMS of Flammulina velutipes (SMS-MF) had no effect on apparent nutrient digestibility, feed intake, velvet antler production, and biochemical indexes. In conclusion, SMS had no effect on serum biochemical indexes and the ratio of the feed weight of the deer supplement to the weight of velvet antler (p > 0.05). At the same time, SMS could reduce the feed consumption and improve the economy by using SMS as a waste resource.

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Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis

Cited by 43 publications

References 16 publications

Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor

Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor

Research Progress of Exosomes in Bone Diseases: Mechanism, Diagnosis and Therapy

Velvet Antler Production and Hematological Changes in Male Sika Deers Fed with Spent Mushroom Substrate

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