Exosomes for angiogenesis induction in ischemic disorders

Moeinabadi-Bidgoli, Kasra; Rezaee, Malihe; Babajani, Amirhesam; Aghdaei, Hamid Asadzadeh; Arki, Mandana Kazem; Afaghi, Siamak; Niknejad, Hassan; Vosough, Massoud

doi:10.1111/jcmm.17689

Cited by 12 publications

(4 citation statements)

References 230 publications

(331 reference statements)

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“…Angiogenic factors like VEGF, FGF, Ang-1, and Ang-2, among others can be found in MSC exosomes. Also, important angiogenic miRNA as −107, −31, −126, 26a, and -20b-5p [73]. Their anti-inflammatory and immunomodulatory properties made them capable to regulate macrophage polarization [74,75].…”

Section: Mesenchymal Stem Cell-derived Exosomes As a Potential Treatmentmentioning

confidence: 99%

Exosomes in Reperfusion Injuries: Role in Pathophysiology and Perspectives as Treatment

G. Verdugo-Molinares,

Ku-Centurion,

Melo

2024

Cardiology and Cardiovascular Medicine

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This chapter focuses on the emerging field of exosomes in the context of reperfusion injuries. Exosomes, nano extracellular vesicles with diverse cargo, play a crucial role in cell-to-cell communication. Exosome quantity and content changes have been implicated in various pathologies, including kidney, brain, heart, and liver ischemia-reperfusion injury. Particularly, exosomes derived from mesenchymal stem cells (MSCs) have shown promising potential as a treatment approach. This chapter aims to provide a comprehensive understanding of exosome biogenesis, the role of organ-specific exosomes in reperfusion injury pathophysiology, and the advantages and prospects of exosome-based treatments. By exploring the multifaceted aspects of exosomes in reperfusion injuries, this chapter will contribute to the advancement of knowledge in this field.

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Section: Mesenchymal Stem Cell-derived Exosomes As a Potential Treatmentmentioning

confidence: 99%

Exosomes in Reperfusion Injuries: Role in Pathophysiology and Perspectives as Treatment

G. Verdugo-Molinares,

Ku-Centurion,

Melo

2024

Cardiology and Cardiovascular Medicine

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“…EVs are mediators of intercellular communication that contain multiple bioactive components such as growth factors, protein, microRNAs and nucleic acids, and activate signaling pathways in targeted cell. Exosomes derived from different cell types has been reviewed to promote or inhibit ECs angiogenesis through various mechanisms including regulating mitochondrial function in normal physiology and pathological conditions [ 273 , 274 ]. For example, adipose-derived EVs promoted HUVECs tube formation and angiogenesis more than bone marrow-derived EVs, while also maximizing HUVECs mitochondrial respiration and ATP production [ 275 ].…”

Section: Other Mitochondrial Protein In Ecs Angiogenesismentioning

confidence: 99%

Mitochondria in endothelial cells angiogenesis and function: current understanding and future perspectives

et al. 2023

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Endothelial cells (ECs) angiogenesis is the process of sprouting new vessels from the existing ones, playing critical roles in physiological and pathological processes such as wound healing, placentation, ischemia/reperfusion, cardiovascular diseases and cancer metastasis. Although mitochondria are not the major sites of energy source in ECs, they function as important biosynthetic and signaling hubs to regulate ECs metabolism and adaptations to local environment, thus affecting ECs migration, proliferation and angiogenic process. The understanding of the importance and potential mechanisms of mitochondria in regulating ECs metabolism, function and the process of angiogenesis has developed in the past decades. Thus, in this review, we discuss the current understanding of mitochondrial proteins and signaling molecules in ECs metabolism, function and angiogeneic signaling, to provide new and therapeutic targets for treatment of diverse cardiovascular and angiogenesis-dependent diseases.

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“…Paracrine capacity and the post-transplantation survival rate of amniotic cells could be improved by cell preconditioning and genetic modification strategies, which could further ameliorate their therapeutic potential [ 99 ]. Amniotic cell-derived exosomes are another appropriate cell-free therapeutic option to consider for the delivery of therapeutic drugs, growth factors, nucleic acids, and regulatory proteins [ 100 , 101 ].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Amniotic Membrane and Its Derivatives: Novel Therapeutic Modalities in Liver Disorders

Arki,

Moeinabadi-Bidgoli,

Hossein-Khannazer

et al. 2023

Cells

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The liver is a vital organ responsible for metabolic and digestive functions, protein synthesis, detoxification, and numerous other necessary functions. Various acute, chronic, and neoplastic disorders affect the liver and hamper its biological functions. Most of the untreated liver diseases lead to inflammation and fibrosis which develop into cirrhosis. The human amniotic membrane (hAM), the innermost layer of the fetal placenta, is composed of multiple layers that include growth-factor rich basement membrane, epithelial and mesenchymal stromal cell layers. hAM possesses distinct beneficial anti-fibrotic, anti-inflammatory and pro-regenerative properties via the secretion of multiple potent trophic factors and/or direct differentiation into hepatic cells which place hAM-based therapies as potential therapeutic strategies for the treatment of chronic liver diseases. Decellularized hAM is also an ideal scaffold for liver tissue engineering as this biocompatible niche provides an excellent milieu for cell proliferation and hepatocytic differentiation. Therefore, the current review discusses the therapeutic potential of hAM and its derivatives in providing therapeutic solutions for liver pathologies including acute liver failure, metabolic disorders, liver fibrosis as well as its application in liver tissue engineering.

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Exosomes for angiogenesis induction in ischemic disorders

Cited by 12 publications

References 230 publications

Exosomes in Reperfusion Injuries: Role in Pathophysiology and Perspectives as Treatment

Exosomes in Reperfusion Injuries: Role in Pathophysiology and Perspectives as Treatment

Mitochondria in endothelial cells angiogenesis and function: current understanding and future perspectives

Amniotic Membrane and Its Derivatives: Novel Therapeutic Modalities in Liver Disorders

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