Exosomes Explosion for Cardiac Resuscitation∗

Liang, Yaxuan; Sahoo, Susmita

doi:10.1016/j.jacc.2015.06.1302

Cited by 11 publications

(9 citation statements)

References 8 publications

(7 reference statements)

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“…A large number of studies, including one of the first investigations from our laboratory, are building a consensus that exosomes constitute a key paracrine component that mediate the reparative function of stem cells in the heart. 77 , 158 – 161 …”

Section: Shedding a New Light On Cardiovascular Diagnostics And Theramentioning

confidence: 99%

Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases

et al. 2021

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Exosomes are small membrane-bound vesicles of endocytic origin that are actively secreted. The potential of exosomes as effective communicators of biological signaling in myocardial function has previously been investigated, and a recent explosion in exosome research not only underscores their significance in cardiac physiology and pathology, but also draws attention to methodological limitations of studying these extracellular vesicles. In this review, we discuss recent advances and challenges in exosome research with an emphasis on scientific innovations in isolation, identification, and characterization methodologies, and we provide a comprehensive summary of web-based resources available in the field. Importantly, we focus on the biology and function of exosomes, highlighting their fundamental role in cardiovascular pathophysiology to further support potential applications of exosomes as biomarkers and therapeutics for cardiovascular diseases.

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Section: Shedding a New Light On Cardiovascular Diagnostics And Theramentioning

confidence: 99%

Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases

et al. 2021

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“…Exosomes from cardiomyocytes were first isolated in 2007 from rat primary cell culture, using ultracentrifugation and differential centrifugation techniques [84]. Since then, a large number of studies described heart-derived exosomal cargo in physiological and pathological conditions [85]. In one of them, the researchers measured the level of four cardiac-specific miRNAs (miR-1, miR-208a, miR-133a, miR-499) in rat models of the cardiac fibrosis process and confirmed miR-208a participation in fibroblast proliferation and differentiation [86].…”

Section: Heartmentioning

confidence: 99%

Inclusion Biogenesis, Methods of Isolation and Clinical Application of Human Cellular Exosomes

Tschuschke

Kocherova

Bryja

et al. 2020

JCM

130

101

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Exosomes are a heterogenous subpopulation of extracellular vesicles 30–150 nm in range and of endosome-derived origin. We explored the exosome formation through different systems, including the endosomal sorting complex required for transport (ESCRT) and ESCRT-independent system, looking at the mechanisms of release. Different isolation techniques and specificities of exosomes from different tissues and cells are also discussed. Despite more than 30 years of research that followed their definition and indicated their important role in cellular physiology, the exosome biology is still in its infancy with rapidly growing interest. The reasons for the rapid increase in interest with respect to exosome biology is because they provide means of intercellular communication and transmission of macromolecules between cells, with a potential role in the development of diseases. Moreover, they have been investigated as prognostic biomarkers, with a potential for further development as diagnostic tools for neurodegenerative diseases and cancer. The interest grows further with the fact that exosomes were reported as useful vectors for drugs.

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“…Exosomes are 30–100 nm tiny vesicles secreted by a variety of cell types including adult stem cells . The regenerative potential of exosomes treating in heart diseases has been demonstrated by many groups . Nevertheless, the extraction of exosomes is still lack standard methods, and only a small number of exosomes can be produced from stem cell‐conditioned media.…”

Section: Introductionmentioning

confidence: 99%

Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future

Tang

Cores

Huang

et al. 2018

Stem Cells Translational Medicine

102

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Stem cell therapy is a promising strategy for tissue regeneration. The therapeutic benefits of cell therapy are mediated by both direct and indirect mechanisms. However, the application of stem cell therapy in the clinic is hampered by several limitations. This concise review provides a brief introduction into stem cell therapies for ischemic heart disease. It summarizes cell‐based and cell‐free paradigms, their limitations, and the benefits of using them to target disease. stem cells translational medicine 2018;7:354–359

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Exosomes Explosion for Cardiac Resuscitation∗

Abstract: Graphical Abstract

Cited by 11 publications

References 8 publications

Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases

Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases

Inclusion Biogenesis, Methods of Isolation and Clinical Application of Human Cellular Exosomes

Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future

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