Exosomes derived from mesenchymal stem cells attenuate inflammation and demyelination of the central nervous system in EAE rats by regulating the polarization of microglia

Li, Zijian; Liu, Fei; He, Xin; Yang, Xue; Shan, Fengping; Feng, Juan

doi:10.1016/j.intimp.2018.12.001

Cited by 200 publications

(141 citation statements)

References 38 publications

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“…Intraperitoneal injection Regulating microglia polarization [46] huc-MSCs EVs Hepatic ischemia-reperfusion injury Intraperitoneal injection Protecting the liver cell apoptosis [58] huc ES-MSCs Exosomes Osteoarthritis Intra-articular injections Promoting chondrocyte proliferation [107,108] can be changed through knockdown of specific proteins. Also, the functions of some groups of proteins can be predicted by GO analysis and this may provide directions for further research.…”

Section: Discussionmentioning

confidence: 99%

“…Similar to macrophage polarization, recent studies found that mouse BMSC-derived exosomes can regulate microglia polarization. The exosomes reduced inflammation and demyelination of the central nervous system in EAE rat models by increasing microglial cell M2 polarization [46]. In some studies of myocardial infarction, BMSC-derived exosomes showed therapeutic potential in improving myocardial function.…”

Section: The Therapeutic Effects Of Exosomes From Bm-mscsmentioning

confidence: 97%

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Extracellular vesicles derived from different sources of mesenchymal stem cells: therapeutic effects and translational potential

et al. 2020

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Mesenchymal stem cells (MSCs) were known to have excellent properties in cell therapy. However, the risk of immune rejection associated with cell transplant therapy hampers its use. Extracellular vesicles secreted by MSCs derived from different sources that contain therapeutic molecules such as RNA and proteins, which is a novel strategy for cell-free therapy. Recently, researches show EVs from MSCs (MSC-EVs) of different sources have special functions and effects on different diseases. Here, we collected these researches and compared them to each other. In addition, their potential and possible application in clinical treatment are described.

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Section: Discussionmentioning

confidence: 99%

Section: The Therapeutic Effects Of Exosomes From Bm-mscsmentioning

confidence: 97%

Extracellular vesicles derived from different sources of mesenchymal stem cells: therapeutic effects and translational potential

et al. 2020

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“…Recently, Li et al (75) demonstrated that MSC-derived exosomes polarize microglia cells mainly into the M2 phenotype and consequently alleviate clinical scores of EAE. In this study, the balance of M1/M2 in EAE rates significantly deviated toward M2 phenotype and their cytokines profile (IL-10 and TGF-β), while frequency and activity of M1 cells were decreased.…”

Section: Multiple Sclerosismentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Ace Card to Address Autoimmune Diseases

Baharlooi

Azimi

Salehi

et al. 2020

IJSC

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With the development of novel treatments for autoimmune disorders, it has become a popular research focus which mesenchymal stem cells (MSCs) have the capacity to counteract with autoimmune diseases progression. One of the underlying mechanisms behind their activities is the release of extracellular vesicles especially exosomes. MSC-derived exosomes are hypoimmunogenic nanocarriers which contain numerous immunoregulatory factors and similar to other exosomes, are able to pass through boundaries like the blood-brain barrier (BBB). Accumulating evidence provided by animal studies has demonstrated that MSC-derived exosomes, as a novel therapy, can re-induce self-tolerance, without subsequent complications reported for other treatments. Therefore, therapeutic applications of MSC-derived exosomes are contributing to core advances in the field of autoimmune diseases. Here, we briefly describe the biological characteristics of MSC-derived exosomes and review the experimentally verified outcomes for autoimmune disease therapy purposes.

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“…In the ischemic stroke model, LPS-exo exhibited potent anti-in ammatory and neuroprotective roles by skewing microglia polarity from the M1 phenotype to the M2 phenotype [25]. In multiple sclerosis (MS), BMSC-derived exosomes attenuated in ammation and demyelination of the CNS by regulating microglia polarization in an EAE animal model [26].…”

Section: Discussionmentioning

confidence: 99%

EphA2-mediatedM1-like polarization of microglia attenuatesglioblastoma metastasis

Liao¹,

Fang²,

Tian³

et al. 2020

Preprint

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BackgroundEphA2 is upregulated in GBM tumor tissue specimens and established cancer cell lines and thought to be an attractive therapeutic target in cancer. We aim to define the role of EphA2 in polarization of microglia.MethodsQuantitative real-time polymerase chain reaction, immunofluorescence staining, and viral transfection-based knockdown and overexpression assays to assess the effect of EphA2 on microglia polarization. iTRAQ-LC-MS/MS and western blot were conducted to detect EphA2 and PI3K-Akt signaling activity. Using the Millicell system as an in vitro co-culture model, we performed transwell and western blot assays investigate the role of EphA2-mediated M1-like of microglia on GBM cells invasion and migration in vitro and in vivo. ResultsIn overexpressing and silencing experiments, we demonstrated that EphA2 contributed to the M1-like polarization of microglia. Mechanistically, PI3K-AKT signaling was the downstream of EphA2 and supported the process of EphA2 mediated the M1-like polarization of microglia. Finally, EphA2 mediated the M1-like polarization of microglia attenuated the migration and invasion ability of GBM cells in vitro and in vivo.ConclusionsOur study indicates that, distinct from its role on cancer cells, EphA2 promoted the M1-like polarization of microglia and further attenuated the metastasis of GBM.Our results provide a new information on rationale for targeting EphA2 to improve treatment outcomes in GBM patients.

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Exosomes derived from mesenchymal stem cells attenuate inflammation and demyelination of the central nervous system in EAE rats by regulating the polarization of microglia

Cited by 200 publications

References 38 publications

Extracellular vesicles derived from different sources of mesenchymal stem cells: therapeutic effects and translational potential

Extracellular vesicles derived from different sources of mesenchymal stem cells: therapeutic effects and translational potential

Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Ace Card to Address Autoimmune Diseases

EphA2-mediatedM1-like polarization of microglia attenuatesglioblastoma metastasis

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